Results 141 to 150 of about 2,828 (161)

Diosmetin: An Anti‐Leukemic Flavonoid Targeting the Estrogen Receptor β

The FASEB Journal, 2016
Acute myeloid leukemia (AML) is an aggressive hematological malignancy resulting from the accumulation of immature myeloid cells in the peripheral blood and bone marrow. It is associated with poor prognosis, especially in older patients where the 2‐year survival rate is approximately 10%.
Sarah G. Rota, Alessia Roma, Paul A. Spagnuolo   +2 more
openaire   +1 more source

Investigating In silico and In vitro Therapeutic Potential of Diosmetin as the Anti-Parkinson Agent

Protein & Peptide Letters
Aim: This study aimed to investigate how diosmetin interacts with seven target receptors associated with oxidative stress (OS) and validate its antioxidant properties for the potential management of Parkinson’s disease (PD). Background: In PD, the degeneration of dopaminergic cells is strongly influenced by OS. This stressor is intricately connected
Krishna Kumar, Varshney, Jeetendra Kumar, Gupta, Rajnish, Srivastava   +2 more
openaire   +2 more sources

Diosmetin Promotes Early Embryonic Development in Pigs by Alleviating Oxidative Stress

Molecular Reproduction and Development
ABSTRACTDiosmetin (DIOS), a natural flavonoid monomer derived from lemons and present in various plants such as spearmint and spider moss, exhibits antioxidant, anti‐inflammatory, and antiaging properties. Nonetheless, its impact on early embryonic development in pigs remains unexplored.
Jia-Jun, Ren, Xiu-Wen, Yuan, Zi-Long, Meng, Neng-Hao, Cao, Yong-Nan, Xu, Nam-Hyung, Kim, Ying-Hua, Li   +6 more
openaire   +2 more sources

Diosmetin attenuates fibromyalgia-like symptoms in a reserpine-induced model in mice

Inflammopharmacology
Fibromyalgia is a potentially disabling idiopathic disease characterized by widespread chronic pain associated with comorbidities such as fatigue, anxiety, and depression. Current therapeutic approaches present adverse effects that limit adherence to therapy.
Lara Panazzolo Marquezin, Maria Fernanda Pessano Fialho, Amanda Favarin, Jéssica Dotto de Lara, Micheli Mainardi Pillat, Denis Broock Rosemberg, Sara Marchesan Oliveira   +6 more
openaire   +2 more sources

Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis

Acta Pharmacologica Sinica, 2021
Cheng Yang, Honggang Zhou, Hao Ruan
exaly  

Diosmetin alleviates cerebral ischemia‐reperfusion injury through Keap1‐mediated Nrf2/ARE signaling pathway activation and NLRP3 inflammasome inhibition

Environmental Toxicology, 2022
Jianqiang Wang
exaly  

Diosmetin alleviates S. aureus-induced mastitis by inhibiting SIRT1/GPX4 mediated ferroptosis

Life Sciences, 2023
exaly  

Diosmin (Diosmetin-7-O-rutinoside)

2013
openaire   +1 more source

Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin

Biomedical Chromatography, 2009
Marios Spanakis, Ioannis Niopas
exaly  

Anti-inflammatory effects of natural flavonoid diosmetin in IL-4 and LPS-induced macrophage activation and atopic dermatitis model

International Immunopharmacology, 2020
exaly