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A validated HPLC determination of the flavone aglycone diosmetin in human plasma

Biomedical Chromatography, 2004
AbstractDiosmetin, 3′,5,7‐trihydroxy‐4′‐methoxyflavone, is the aglycone of the flavonoid glycoside diosmin that occurs naturally in foods of plant origin. Diosmin exhibits antioxidant and anti‐inflammatory activities, improves venous tone and it is used for the treatment of chronic venous insufficiency.
Feras Imad, Kanaze   +2 more
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Diosmetin: A dietary flavone as modulator of signaling pathways in cancer progression

Molecular Carcinogenesis
AbstractFlavonoids, constituting the most extensive category of polyphenols, founds in a variety of plants and comprise over 9000 compounds. Diosmetin, O‐methylated flavone (3’,5,7‐trihydroxy‐4’‐methoxyflavone) of flavonoid aglycone diosmin have witnessed a significant surge in recent years.
Waseem Raza, Abha Meena, Suaib Luqman
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A toxicological evaluation for safety assessment of ruthenium-based diosmetin complex in rats

Regulatory Toxicology and Pharmacology, 2023
The flavonoid-based organometallic complexes have been identified as novel bioactive compounds with enhanced pharmacological and therapeutic activity. In this study, the ruthenium-p-cymene diosmetin complex was synthesized, characterized, and investigated for toxicological profiling through different toxicological and genotoxicological studies which ...
Sidhanta Sil   +4 more
openaire   +2 more sources

Recent Advances in Diosmetin: Pharmacological, Pharmacokinetic, and Toxicological Profile

Current Topics in Medicinal Chemistry
Diosmetin, also known as 3´, 5, 7-trihydroxy-4´-methoxyflavone, is a bioflavonoid that can be found in several food sources. These include mainly citrus fruits and plants, such as Rosmarinus officinalis, Citrus sinensis, Galium verum, and Rosa agrestis.
Bhoopendra Singh   +2 more
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ChemInform Abstract: Synthesis of Two New Diosmetin Ethers.

ChemInform, 1996
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
R. MOSQUERA, A. ORJALES
openaire   +1 more source

Simultaneous determination of the flavonoid aglycones diosmetin and hesperetin in human plasma and urine by a validated GC/MS method: in vivo metabolic reduction of diosmetin to hesperetin

Biomedical Chromatography, 2008
AbstractDiosmetin and hesperetin are the aglycones of the flavonoid glycosides diosmin and hesperidin which occur naturally in citrus fruit. A GC/MS method for the simultaneous determination of diosmetin and hesperetin in human plasma and urine has been developed and validated.
Marios, Spanakis   +2 more
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ChemInform Abstract: New Amino and Mercapto Derivatives of Diosmetin

ChemInform, 2000
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A. Orjales, R. Mosquera, G. Canal
openaire   +1 more source

Exploring the Multifaceted Potential of Natural Flavonoid Diosmetin in Human Diseases

Current Pharmaceutical Design
Flavonoids are secondary metabolites that are closely related to polyphenols and have a diverse structure. These are present in the form of aglycones or glycosides in many fruits and vegetables. Diosmetin (DIO) is a bioactive flavonoid primarily found in the olive tree (Olea europaea L) and has been recognised ...
Dhirendra, Singh   +2 more
openaire   +2 more sources

Diosmetin Attenuates Painful Symptoms Caused by Antineoplastics Paclitaxel and Anastrozole in Mice

Molecular Neurobiology
Cancer patients often experience painful symptoms as an adverse effect resulting from various factors, including antineoplastic therapy. Paclitaxel is a chemotherapeutic agent used to treat solid tumours and, unfortunately, causes acute and chronic peripheral neuropathic pain in patients.
Samuel Felipe Atuati   +2 more
openaire   +2 more sources

Diosmetin Substituent in Galium verum L. Acting on Venous Thrombosis

2010 4th International Conference on Bioinformatics and Biomedical Engineering, 2010
Galium verum L. is a wild plant from Northeast China, this grass is well known as an excellent food source of vitamin, and it also contains phytochemicals such as chlorogenic acid,salicylic acid and flavone. The present work evaluates the anti-venous thrombosis capacity of hydrophilic extracts of Galium.
Lianrong Du   +3 more
openaire   +1 more source

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