Results 61 to 70 of about 2,537 (174)

Dietary anthocyanidin pelargonidin activates G protein‐coupled receptor 35

The FEBS Journal, Volume 293, Issue 5, Page 1386-1399, March 2026.
Pelargonidin, a red‐fruit‐derived anthocyanidin, was newly identified as a dietary agonist of GPR35, a metabolite‐sensing GPCR implicated in anti‐inflammation. Through screening of dietary compounds, pelargonidin emerged as a potent GPR35 agonist, attenuating inflammation in human intestinal cells.
Fumie Nakashima, Sayako Shimomura, Mayuka Wakabayashi, Wei Qi Loh, Harumi Ando, Haruka Sei, Hiroyuki Hattori, Didik Huswo Utomo, Masaki Kita, Asuka Inoue, Koji Uchida, Takahiro Shibata   +11 more
wiley   +1 more source

Is Nonmicronized Diosmin 600 mg as Effective as Micronized Diosmin 900 mg plus Hesperidin 100 mg on Chronic Venous Disease Symptoms? Results of a Noninferiority Study

International Journal of Vascular Medicine, 2020
Background. Phlebotonics have beneficial effects on some symptoms related to chronic venous disease (CVD) of the lower limbs. The most commonly used one is diosmin, available in a pure semisynthetic form or as a micronized purified flavonoid fraction ...
Marcio Steinbruch, Carlos Nunes, Romualdo Gama, Renato Kaufman, Gustavo Gama, Mendel Suchmacher Neto, Rafael Nigri, Natasha Cytrynbaum, Lisa Brauer Oliveira, Isabelle Bertaina, François Verrière, Mauro Geller   +11 more
doaj   +1 more source

Nephroprotective Potential of Ginger, Diosmin, and Their Combination on Induced Diabetic Nephropathy in a Rat Model: Light and Electron Microscopic Observations [PDF]

The Egyptian Journal of Histology
Introduction: Hyperglycemia is a chronic illness that is associated with diabetes. Patients with diabetes have been found to have many alterations in their renal functioning.
Samar Gad, Samia Manawy, Manar Foda, Dania Mohammed, Kamal Kamal   +4 more
doaj   +1 more source

Exploitation of the Antibacterial Activity of Micromeria graeca L. Extracts From Northern Morocco

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
Among the various extraction techniques investigated, the methanolic ultrasound‐assisted extract (MGME‐UAE) of Micromeria graeca L exhibited the strongest bactericidal effect, selectively inhibiting Proteus mirabilis (inhibition zone 12.7 ± 0.6 mm; MIC = 6.25 mg/mL).
Houda Chtibi, Kaoutar Harboul, Taoufiq Benali, Aziz Bouymajane, Roberto Laganà Vinci, Francesco Cacciola, Luigi Mondello, Khalil Hammani   +7 more
wiley   +1 more source

Pharmacokinetic Profile of μSMIN Plus™, a new Micronized Diosmin Formulation, after Oral Administration in Rats

Natural Product Communications, 2015
Diosmin is a naturally occurring flavonoid present in citrus fruits and other plants belonging to the Rutaceae family. It is used for the treatment of chronic venous insufficiency (CVI) for its pheblotonic and vaso-active properties, safety and ...
Rosario Russo, Angelo Mancinelli, Michele Ciccone, Fabio Terruzzi, Claudio Pisano, Lorella Severino   +5 more
doaj   +1 more source

Hepatoprotective effects of diosmin: a narrative review

Naunyn-Schmiedeberg's Archives of Pharmacology
Abstract Liver diseases represent a formidable global health threat. Hesperidin, a flavonoid found in citrus fruits, is the source of diosmin (DS). The in vivo and in vitro investigations of the pharmacological effects of DS reveal that it exhibits tremendous beneficial effects, such as fighting against inflammation, oxidative stress, and ...
Hassanein, Emad H. M., Althagafy, Hanan S., Baraka, Mohammad A., Amin, Haitham   +3 more
openaire   +2 more sources

Role of diosmin in preventing doxorubicin-induced cardiac oxidative stress, inflammation, and hypertrophy: A mechanistic approach

Saudi Pharmaceutical Journal
Chemotherapeutic drugs, such as doxorubicin (Dox), are commonly used to treat a variety of malignancies. However, Dox-induced cardiotoxicity limits the drug’s clinical applications.
Abdullah F. AlAsmari, Mohammed M. Al-Shehri, Nasser Algarini, Nada A. Alasmari, Alabid Alhazmi, Mohammed AlSwayyed, Metab Alharbi, Fawaz Alasmari, Nemat Ali   +8 more
doaj   +1 more source

Effect of Diosmin Administration in Patients with Chronic Venous Disorders on Selected Factors Affecting Angiogenesis

Molecules, 2019
Diosmin is a natural compound with a wide range of biological activity, e.g., it improves lymphatic drainage, supports microcirculation, and increases venous tone, and venous elasticity, hence, it is applied in the pharmacotherapy of chronic venous ...
Marcin Feldo, Magdalena Wójciak-Kosior, Ireneusz Sowa, Janusz Kocki, Jacek Bogucki, Tomasz Zubilewicz, Jan Kęsik, Anna Bogucka-Kocka   +7 more
doaj   +1 more source

Polymer carrier selection for creation of diosmin solid dispersion system by hot melt extrusion

Разработка и регистрация лекарственных средств
Introduction. The extremely unfavorable physical, chemical and functional properties of diosmin, a component of a number of popular phleboprotective drugs, cause an increased therapeutic dosage of the active pharmaceutical ingredient (API) in the dosage ...
A. A. Danilova, E. V. Vishnyakov, E. S. Surbeeva, K. A. Gusev, D. N. Maimistov, E. V. Flisyuk   +5 more
doaj   +1 more source

The Effect of Diosmin Hesperidin on Intestinal Ischaemia — Reperfusion Injury

Acta Chirurgica Belgica, 2004
The effect of Diosmin Hesperidin on intestinal ischaemia reperfusion injury was evaluated in an experimental model in rats.Forty Spraque-Dawley rats were divided into 4 groups of (n = 10) (sham, sham + Diosmin Hesperidin, Reperfusion, Reperfusion + Diosmin Hesperidin).
Pehlivan, Mevlüt, Hazinedaroğlu, Selçuk Mevlüt, Kayaoğlu, Hüseyin Ayhan, Erkek, Ayhan Bülent, Keklik, T., Canbolat, Orhan, Koçak, Suzan   +6 more
openaire   +4 more sources