Results 101 to 110 of about 28,724 (253)
The FEBS Journal, EarlyView.Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory +3 more
wiley +1 more source
Persistent enhancement of cell-mediated and antibody immune responses after administration of muramyl dipeptide derivatives with antigen in metabolizable oil [PDF]
, 1981 C Carelli, F Audibert, L Chedid
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International Journal of Cosmetic Science, EarlyView.The blend enhanced antioxidation, anti‐glycation, autophagy and circadian regulation in cell and skin models. Key markers included mitochondrial ROS, γ‐H2AX, AGEs, ATP, melatonin, LC3 and SOD. Significant improvements were visualized via fluorescence and quantified with statistical markers.
Lina Wang +4 more
wiley +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Base excision repair (BER) is a critical pathway for repairing damaged DNA bases in cells; however, the mechanisms of protein recruitment and interaction in this pathway remain largely unexplored in higher plants. In this study, we used ‘84K’ poplar (Populus alba × P.
Aoyu Ling +8 more
wiley +1 more source
Two mechanisms of membrane digestion: enzymatic-transport ensemble exists for oligopeptides as well
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011 Aim of investigation. To determine, which mechanism of dipeptide transport is realized under experimental conditions: PEPT1-mediated transport of the intact dipeptides or transport of the amino acid formed as a result of membrane hydrolysis of dipeptides
S. T. Metelsky, V. T. Ivashkin
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Veterinary Clinical Pathology, EarlyView.ABSTRACT Background Monitoring the metabolic changes during the periparturient period is crucial. Objective We aimed to establish reference intervals (RIs) of several serum and plasma biochemical variables in multiparous periparturient Holstein dairy cows. Methods A total of 238 multiparous dry cows from six commercial dairy farms were enrolled.
Nektarios Siachos +6 more
wiley +1 more source
Synthesis of
, 2019 Soichiro Kano +3 more
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Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.ABSTRACT Background Proteolytic processing is a fundamental post‐translational modification. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) workflows are powerful for degradomic analyses but inherently sacrifice spatial information, a critical aspect for investigating biological systems such as aberrant extracellular matrix remodeling and ...
Mujia Jenny Li +8 more
wiley +1 more source
Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source