Results 121 to 130 of about 28,724 (253)
Glia, Volume 74, Issue 2, February 2026.ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu +6 more
wiley +1 more source
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson +9 more
wiley +1 more source
Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu +4 more
wiley +1 more source
Spectral features of Trp-Trp dipeptides using PSSS-templated silver nanoparticles
, 2015 Yufeng Yuan +4 more
openalex +1 more source
Journal of Peptide Science, Volume 32, Issue 2, February 2026.The constrained tryptophan (Trp) analog 1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid (Tcc) is used to restrict peptide conformation in structure–activity relationship studies. Although Pictet–Spengler cyclization of Trp and aldehydes with mineral acid gives Tcc analogs, such harsh conditions do not tolerate acid‐labile functionality.
Omer S. L. N'dri +10 more
wiley +1 more source
Translation‐Promoting Effects of RNA Template Overhangs in the Absence of Ribosomes
Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.Ribosome‐free translation of an RNA sequence into a peptide sequence can be controlled by the folding of the template strand. Overhang sequences forming a triplex structure with the templating region and the peptidoyl RNA in pH‐dependent manner increase yields up to 40‐fold through entropic effects and mixed anhydride formation, allowing for controlled,
Nikolaos Giannakopoulos +2 more
wiley +2 more sources
Harnessing Dynamic Self‐Assembly to Accelerate Chemical Reactions
Small Structures, Volume 7, Issue 2, February 2026.Dynamic supramolecular self‐assembly offers a route to regulate chemical reactivity beyond diffusion‐controlled processes. This perspective surveys how dynamic assemblies organize substrates in space and time, increase effective molarity, enable emergent catalysis, and create specified microenvironments to accelerate chemical reactions. Precise control
Shunfei Cui +4 more
wiley +1 more source
Root Microbiota: Orchestrating Architecture‐Smart Crops
Microbial Biotechnology, Volume 19, Issue 2, February 2026.Root‐associated microbiota play an important role in shaping crop architecture. The concept of “holobiont architecture” is proposed, in which plant architecture is dynamically fine‐tuned through synergistic plant–microbiome interactions. This framework offers novel avenues for breeding architecture‐smart crops with improved phenotypic plasticity and ...
Qinqin Chen +3 more
wiley +1 more source
Prognostic Impact of DPP4 Inhibitors on Systemic Drug Therapy for Advanced Kidney Cancer Patients
Cancer Science, Volume 117, Issue 2, Page 468-475, February 2026.Treatment with DPP4 inhibitors was identified as a favorable prognostic factor in patients with advanced RCC. A more substantial degree of tumor shrinkage was observed in the subgroup of patients who received tyrosine kinase inhibitors or immune checkpoint inhibitors as first‐line therapy.
Shuhei Kamada +12 more
wiley +1 more source