Results 11 to 20 of about 38,518 (252)
Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions
Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs
Yeting Guo +15 more
doaj +3 more sources
Fine‐Tuning Supramolecular Assemblies by Controlling Micellar Aggregates
Supramolecular assembly can be used to fabricate complex functional materials by organizing simple building blocks. However, it is difficult to control the hierarchical assembly across multiple length scales.
Dipankar Ghosh +7 more
doaj +1 more source
The Synthesis of (2R)-Aziridine-2-carboxylic Acid Containing Dipeptides
Optimized conditions for the synthesis of fully deprotected (2R)-aziridine containing dipeptides are described. Preparation of fully protected N- and C- terminal aziridine containing dipeptides was found to be straightforward and high yielding for the ...
Samo Kuzmič, Martina Hrast, Rok Frlan
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Feedback Regulation of Cathepsin C by the Propeptide Dipeptides of Granzymes A and B
Granzymes A and B are activated by proteolytic removal of their N-terminal dipeptides by cathepsin C (dipeptidyl-peptidase I). However, the possible physiological role of the cleaved dipeptides Glu-Lys and Gly-Glu is not yet understood.
Janja Božič, Iztok Dolenc
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Dipeptides 1 and 2 were synthesized from unnatural amino acids containing pyrene as a fluorescent label and polynucleotide binding unit, and modified tyrosine as a photochemically reactive unit.
Igor Sviben +6 more
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Neighbouring residue effects on the ^(15)N chemical shifts of some aliphatic dipeptides [PDF]
The ^(15)N chemical shifts of a number of simple aliphatic dipeptides have been determined in a aqueous solution and while the amine nitrogen shift is independent of the nature of the neighbouring residue, the peptide nitrogen shift shows a marked ...
Loftus, Philip +3 more
core +1 more source
Density Functional Studies on Secondary Amides: Role of Steric Factors in Cis/Trans Isomerization
Cis/trans isomerization of amide bonds is a key step in a wide range of biological and synthetic processes. Occurring through C-N amide bond rotation, it also coincides with the activation of amides in enzymatic hydrolysis.
Balmukund S. Thakkar +2 more
doaj +1 more source
Aqueous Amino Acids and Proteins Near the Surface of Gold in Hydrophilic and Hydrophobic Force Fields [PDF]
We calculate potentials of the mean force for twenty amino acids in the vicinity of the (111) surface of gold, for several dipeptides, and for some analogs of the side chains, using molecular dynamics simulations and the umbrella sampling method.
Cieplak, Marek, Nawrocki, Grzegorz
core +1 more source
The female schistosome's dependence on the male to reach sexual maturity has puzzled scientists for decades. Using various molecular techniques, Chen et al. dissect the synthesis pathway of the β-alanyl-tryptamine dipeptide (BATT), emitted by the male into its environment, which induces sexual maturation and egg-laying in the female.
Yohann Le Govic +2 more
openaire +4 more sources
The New Dipeptide TSPO Ligands: Design, Synthesis and Structure–Anxiolytic Activity Relationship
The translocator protein (TSPO, 18 kDa) plays an important role in the synthesis of neurosteroids by promoting the transport of cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step in neurosteroidogenesis ...
Tatiana A. Gudasheva +6 more
doaj +1 more source

