Divergent Access to α,β-Unsaturated Thiolated and Selenolated Lactams via a Unified Palladium-Catalyzed Carbonylative Transformation. [PDF]
Org LettYin Z, Sun S, Qin X, Li H, Zhu F, Wu XF.
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Synthesis and anti-cancer activity of naphthalimide-organylselanyl conjugates. [PDF]
Beilstein J Org ChemRavi R, Karuthapandi S.
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Synergistic diselenide/guanidine catalyzed dehydrophosphorylation of 2-nitrobenzhydrols to access C-stereogenic phosphinates. [PDF]
Chem SciGong JY +6 more
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On the mechanisms involved in antinociception induced by diphenyl diselenide
Environmental Toxicology and Pharmacology, 2005In this study, we described the local peripheral antinociceptive activity produced by diphenyl diselenide in the formalin test as compared to ebselen, an amply studied organoselenium compound. A second objective was to evaluate, the possible mechanisms underlying the antinociceptive effect caused by diphenyl diselenide.
Dionéia Araldi +2 more
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Effects of diphenyl diselenide and diphenyl ditellurite on chicken embryo development
Toxicology Mechanisms and Methods, 2013Studies of our group has demonstrated that (PhSe)2 plays some pharmacologic activities. In addition, it is possible that this compound would be an alternative source of organic selenium in animal foods. However, previous works showed that diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 are toxic for mammals, but their undesirable effects ...
Alessandro de Souza Prestes +2 more
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Toxicological evaluation of subchronic exposure to diphenyl diselenide in rats
Journal of Applied Toxicology, 2008AbstractThe aim of this study was to investigate the effects caused by subchronic exposure to diphenyl diselenide in rats. Adult Wistar rats were exposed to diphenyl diselenide (5–300 µmol kg−1, subcutaneously) once a day for 14 days. The subchronic administration of diphenyl diselenide at a dose of 300 µmol kg−1 significantly increased aspartate ...
Flavia Meotti, Nogueira Cw
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Antinociceptive properties of diphenyl diselenide: Evidences for the mechanism of action
European Journal of Pharmacology, 2007The present study examined the acute toxicity and antinociceptive effects of diphenyl diselenide (PhSe)2, given orally (p.o.), in chemical and thermical models of pain in mice. Diphenyl diselenide (7.8-312 mg/kg, p.o.) did not cause mortality. This compound did not change plasma AST (aspartate aminotransferase) and ALT (alanine aminotransferase ...
Diego Alves +2 more
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Effects of diphenyl–diselenide on orofacial dyskinesia model in rats
Brain Research Bulletin, 2006Recently, we have described the beneficial effects of Diphenyl diselenide, an organochalcogen with glutathione peroxidase-like activity, on reserpine-induced orofacial dyskinesia in old rats. In this study, our aim was to examine the effects of diselenide on haloperidol-induced orofacial dyskinesia in rats.
Roselei Fachinetto +2 more
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Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: A pathway for their neuroprotective effects [PDF]
Neuroscience Letters, 2011 Thioredoxin reductase (TrxR) isoforms play important roles in cell physiology, protecting cells against oxidative processes. In addition to its endogenous substrates (Trx isoforms), hepatic TrxR can reduce organic selenium compounds such as ebselen and ...
João Batista Teixeira Rocha
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Physicochemical and Biochemical Profiling of Diphenyl Diselenide
Applied Biochemistry and Biotechnology, 2013The objective of the present study was to evaluate the physicochemical and biochemical profiling of diphenyl diselenide (PhSe)₂, a selenoorganic compound with biological activity. Experimental protocols were established for chemical stability in isotonic phosphate buffer (PBS) pH 7.4 and in simulated gastric and intestinal fluids, biological stability (
Marina, Prigol +4 more
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