Results 111 to 120 of about 1,907 (195)

A mitochondria-targeted nanoantioxidant restores alveolar bone homeostasis in periodontitis by quenching ROS and suppressing the cGAS-STING pathway. [PDF]

Bioact Mater
Huang N, Cao L, Xu Y, Pan L, Zheng A, Wang X, Jiang X.   +6 more
europepmc   +1 more source

50 Years of Organoselenium Chemistry, Biochemistry and Reactivity: Mechanistic Understanding, Successful and Controversial Stories. [PDF]

Chemistry
Madabeni A, Bortoli M, Nogara PA, Ribaudo G, Dalla Tiezza M, Flohé L, Rocha JBT, Orian L.   +7 more
europepmc   +1 more source

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On the mechanisms involved in antinociception induced by diphenyl diselenide

Environmental Toxicology and Pharmacology, 2005
In this study, we described the local peripheral antinociceptive activity produced by diphenyl diselenide in the formalin test as compared to ebselen, an amply studied organoselenium compound. A second objective was to evaluate, the possible mechanisms underlying the antinociceptive effect caused by diphenyl diselenide.
Dionéia Araldi, Gilson Zeni, João B T Rocha   +2 more
exaly   +3 more sources

Attenuation of doxorubicin-induced hypothalamic-pituitary-testicular axis dysfunction by diphenyl diselenide involves suppression of hormonal deficits, oxido-inflammatory stress and caspase 3 activity in rats.

Journal of Trace Elements in Medicine and Biology, 2023
BACKGROUND Doxorubicin (DOX) is one of the popular anti-cancer drugs in the world and several literatures have implicated it in various toxicities especially cardiotoxicity and reproductive toxicity.
Adesina A Babalola, Adedoyin R Adelowo, Oluwatobiloba F. Da-silva, C. N. Ikeji, O. Owoeye, J. Rocha, I. Adedara, E. Farombi   +7 more
semanticscholar   +1 more source

Physicochemical and Biochemical Profiling of Diphenyl Diselenide

Applied Biochemistry and Biotechnology, 2013
The objective of the present study was to evaluate the physicochemical and biochemical profiling of diphenyl diselenide (PhSe)₂, a selenoorganic compound with biological activity. Experimental protocols were established for chemical stability in isotonic phosphate buffer (PBS) pH 7.4 and in simulated gastric and intestinal fluids, biological stability (
Marina, Prigol, Cristina W, Nogueira, Gilson, Zeni, Maria Rosário, Bronze, Luís, Constantino   +4 more
openaire   +2 more sources

Genotoxicity of diphenyl diselenide in bacteria and yeast

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2004
Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organic selenium compounds. This may increase the risk of human exposure to the chemical at the workplace. We have determined its mutagenic potential in the Salmonella/microsome assay and used the yeast Saccharomyces cerevisiae to assay
Renato Moreira, Rosa, Krisley, Sulzbacher, Jaqueline Nascimento, Picada, Rafael, Roesler, Jenifer, Saffi, Martin, Brendel, João Antonio Pêgas, Henriques   +6 more
openaire   +2 more sources

Antisecretory and antiulcer effects of diphenyl diselenide

Environmental Toxicology and Pharmacology, 2006
The antisecretory and antiulcer effects of diphenyl diselenide were studied in vivo and in vitro. Diphenyl diselenide, administered intraperitoneally prevented the development of gastric lesions induced by ethanol and indomethacin. There was no difference in plasma uric acid concentrations in diphenyl diselenide-treated rats with gastric lesions ...
Lucielli, Savegnago, Marcio, Trevisan, Diego, Alves, Joao Batista Teixeira, Rocha, Cristina W, Nogueira, Gilson, Zeni   +5 more
openaire   +2 more sources

Toxicological evaluation of subchronic exposure to diphenyl diselenide in rats

Journal of Applied Toxicology, 2008
AbstractThe aim of this study was to investigate the effects caused by subchronic exposure to diphenyl diselenide in rats. Adult Wistar rats were exposed to diphenyl diselenide (5–300 µmol kg−1, subcutaneously) once a day for 14 days. The subchronic administration of diphenyl diselenide at a dose of 300 µmol kg−1 significantly increased aspartate ...
Flavia Carla Meotti, Juliano Perottoni, Cristina W Nogueira   +2 more
exaly   +3 more sources

Effects of diphenyl diselenide and diphenyl ditellurite on chicken embryo development

Toxicology Mechanisms and Methods, 2013
Studies of our group has demonstrated that (PhSe)2 plays some pharmacologic activities. In addition, it is possible that this compound would be an alternative source of organic selenium in animal foods. However, previous works showed that diphenyl diselenide (PhSe)2 and diphenyl ditelluride (PhTe)2 are toxic for mammals, but their undesirable effects ...
Carlos André, Prauchner, Alessandro de Souza, Prestes, Cristina W, Nogueira, João B T, Rocha   +3 more
openaire   +2 more sources

Photoinduced Construction of Thieno[3,4-c]quinolin-4(5H)-ones/Selenopheno[3,4-c]quinolin-4(5H)-ones Using Diphenyl Disulfide or Diphenyl Diselenide as Sulfur or Selenium Sources.

Journal of Organic Chemistry, 2022
A photocatalytic synthesis of thieno[3,4-c]quinolin-4(5H)-ones/selenopheno[3,4-c]quinolin-4(5H)-ones using diphenyl disulfide or diphenyl diselenide as sulfur or selenium sources was developed.
Shidong Tian, Jingting Ai, Jia-Hui Han, Weidong Rao, Shusu Shen, Daopeng Sheng, Shun‐Yi Wang   +6 more
semanticscholar   +1 more source