Results 1 to 10 of about 20,520 (197)

Utilization of a deoxynucleoside diphosphate substrate by HIV reverse transcriptase. [PDF]

PLoS ONE, 2008
Deoxynucleoside triphosphates (dNTPs) are the normal substrates for DNA synthesis catalyzed by polymerases such as HIV-1 reverse transcriptase (RT). However, substantial amounts of deoxynucleoside diphosphates (dNDPs) are also present in the cell. Use of
Scott J Garforth, Michael A Parniak, Vinayaka R Prasad   +2 more
doaj   +6 more sources

Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases in Mycobacteria [PDF]

Current Research in Structural Biology
Class I ribonucleotide reductases consisting of α and β subunits convert ribonucleoside diphosphates to deoxyribonucleoside diphosphates involving an intricate free radical mechanism.
Lumbini R. Yadav, Vasudha Sharma, Maheswaran Shanmugam, Shekhar C. Mande   +3 more
doaj   +2 more sources

Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present

Biomolecules, 2022
Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates.
Sarah E. Huff, Jordan M. Winter, Chris G. Dealwis   +2 more
doaj   +1 more source

Potentiating Vγ9Vδ2 T cell proliferation and assessing their cytotoxicity towards adherent cancer cells at the single cell level

Biology Open, 2022
Vγ9Vδ2 T cells is the dominant γδ T cell subset in human blood. They are cytotoxic and activated by phosphoantigens whose concentrations are increased in cancer cells, making the cancer cells targets for Vγ9Vδ2 T cell immunotherapy.
Chenxiao Liu, Karolina Skorupinska-Tudek, Sven-Göran Eriksson, Ingela Parmryd   +3 more
doaj   +1 more source

Efficient adiabatic demagnetization refrigeration to below 50 mK with UHV compatible Ytterbium diphosphates $A$YbP$_2$O$_7$ ($A=$Na, K) [PDF]

Phys. Rev. Applied 20, 014013 (2023), 2023
Attaining milli-Kelvin temperatures is often a prerequisite for the study of novel quantum phenomena and the operation of quantum devices. Adiabatic demagnetization refrigeration (ADR) is an effective, easy and sustainable alternative to evaporation or dilution cooling with the rare and super-expensive $^3$He. Paramagnetic salts, traditionally used for
arxiv   +1 more source

NMR of $^{31}$P Nuclear Spin Singlet States in Organic Diphosphates [PDF]

, 2021
$^{31}$P NMR and MRI are commonly used to study organophosphates that are central to cellular energy metabolism. In some molecules of interest, such as adenosine diphosphate (ADP) and nicotinamide adenine dinucleotide (NAD), pairs of coupled $^{31}$P nuclei in the diphosphate moiety should enable the creation of nuclear spin singlet states, which may ...
arxiv   +1 more source

A Trichome-Specific, Plastid-Localized Tanacetum cinerariifolium Nudix Protein Hydrolyzes the Natural Pyrethrin Pesticide Biosynthetic Intermediate trans-Chrysanthemyl Diphosphate

Frontiers in Plant Science, 2020
Tanacetum cinerariifolium flowers synthesize six pyrethrins that function as effective insecticides. trans-Chrysanthemol is an early intermediate in the synthesis of the monoterpene moiety of pyrethrins.
Wei Li, Wei Li, Daniel B. Lybrand, Haiyang Xu, Haiyang Xu, Fei Zhou, Robert L. Last, Robert L. Last, Eran Pichersky   +8 more
doaj   +1 more source

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

mBio, 2022
Prenyldiphosphate synthases catalyze the reaction of allylic diphosphates with one or more isopentenyl diphosphate molecules to form compounds such as farnesyl diphosphate, used in, e.g., sterol biosynthesis and protein prenylation, as well as longer ...
Melissa A. Sleda, Zhu-Hong Li, Ranjan Behera, Baihetiya Baierna, Catherine Li, Jomkwan Jumpathong, Satish R. Malwal, Makoto Kawamukai, Eric Oldfield, Silvia N. J. Moreno   +9 more
doaj   +1 more source

Transcriptional profile of genes involved in the production of terpenes and glyceollins in response to biotic stresses in soybean [PDF]

Genetics and Molecular Biology, 2020
Terpenes produced by plants comprise a diverse range of secondary metabolites, including volatile organic compounds (VOCs). Terpene VOC production may be altered after damage or by biological stimuli such as bacterial, fungal and insects, and subsequent ...
Talitta Regina Parmezan, Salvador Lima Brito Júnior, Kenia de Carvalho, Moisés de Aquino, Michael Birkett, John Pickett, Estela de Oliveira Nunes, Ricardo Vilela Abdelnor, Clara Beatriz Hoffmann Campo, Francismar Corrêa Marcelino-Guimarães   +9 more
doaj   +1 more source

Lipophilic Nucleoside Triphosphate Prodrugs of Anti‐HIV Active Nucleoside Analogs as Potential Antiviral Compounds

Advanced Science, 2023
Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate prodrugs of different nucleoside analogs is disclosed.
Xiao Jia, Dominique Schols, Chris Meier
doaj   +1 more source