Engineered geranyl diphosphate methyltransferase produces 2-methyl-dimethylallyl diphosphate as a noncanonical C6 unit for terpenoid biosynthesis [PDF]
Synthetic and Systems Biotechnology, 2023 Terpenoids constitute the largest class of natural products with complex structures, essential functions, and versatile applications. Creation of new building blocks beyond the conventional five-carbon (C5) units, dimethylallyl diphosphate (DMAPP) and ...
Chen-Yang Xia +5 more
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Impact of the Warburg effect on nucleotide homeostasis in human retinal endothelial cells and its relevance to proliferative diabetic retinopathy [PDF]
Frontiers in PharmacologyPurposeWhile great progress has been made in screening methods and therapies for proliferative diabetic retinopathy (PDR), it is still a major cause of blindness.
Andrew Gregory +14 more
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The prevalence and co-occurrence of emulsifiers, thickeners and stabilizers in food products on the Norwegian market [PDF]
Food & Nutrition ResearchBackground: As the intake of food that has undergone substantial processing increases, the intake of common additives like Emulsifiers, Thickeners, and Stabilizers (ETSs) also increases.
Åsne Skram Trømborg +3 more
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The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology [PDF]
The Journal of Clinical InvestigationPurine nucleotides are critical for nucleic acid synthesis, signaling, and cellular metabolism. Thiopurines (TPs), including 6-mercaptopurine and 6-thioguanine, are cornerstone agents for the treatment of acute lymphoblastic leukemia (ALL).
Leo Kager, Kaan Boztug
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Inhibitors of the Cancer Target Ribonucleotide Reductase, Past and Present
Biomolecules, 2022 Ribonucleotide reductase (RR) is an essential multi-subunit enzyme found in all living organisms; it catalyzes the rate-limiting step in dNTP synthesis, namely, the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates.
Sarah E. Huff +2 more
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Structural Insights into Broad-Range Polyphosphate Kinase 2-II Enzymes Applicable for Pyrimidine Nucleoside Diphosphate Synthesis. [PDF]
ChembiochemKuge M +11 more
europepmc +3 more sources
Biology Open, 2022 Vγ9Vδ2 T cells is the dominant γδ T cell subset in human blood. They are cytotoxic and activated by phosphoantigens whose concentrations are increased in cancer cells, making the cancer cells targets for Vγ9Vδ2 T cell immunotherapy.
Chenxiao Liu +3 more
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Frontiers in Plant Science, 2020 Tanacetum cinerariifolium flowers synthesize six pyrethrins that function as effective insecticides. trans-Chrysanthemol is an early intermediate in the synthesis of the monoterpene moiety of pyrethrins.
Wei Li +8 more
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Advanced Science, 2023 Nucleoside analogs require three phosphorylation steps catalyzed by cellular kinases to give their triphosphorylated metabolites. Herein, the synthesis of two types of triphosphate prodrugs of different nucleoside analogs is disclosed.
Xiao Jia, Dominique Schols, Chris Meier
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Investigation of Pyrophosphates KYP2O7Co-Doped with Lanthanide Ions Useful for Theranostics
Nanomaterials, 2019 Diphosphate compounds (KYP2O7) co-doped with Yb3+ and Er3+ ions were obtained by one step urea assisted combustion synthesis. The experimental parameters of synthesis were optimized using an experimental design approach related to co-dopants ...
Adam Watras +5 more
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