Results 61 to 70 of about 93,979 (223)

Think Beyond The Core: Computationally Decoding the Hydrophilic Corona of Drug‐Loaded Polymer Micelles

Small, EarlyView.
Drug‐loaded ABA‐type triblock copolymer micelles with a hydrophobic poly(2‐n‐butyl‐2‐oxazine) core (B‐block) and hydrophilic coronas (pEG, pDMAA, pSAR (A‐block)) are investigated by all‐atom molecular dynamics simulations at 20% and 60% curcumin loadings.
Maksym Karachevtsev, Josef Kehrein, Terttu Hukka, Alex Bunker, Mikko Karttunen, Robert Luxenhofer   +5 more
wiley   +1 more source

Synthesis with Perfect Atom Economy: Generation of Furan Derivatives by 1,3-Dipolar Cycloaddition of Acetylenedicarboxylates at Cyclooctynes

Molecules, 2014
Cyclooctyne and cycloocten-5-yne undergo, at room temperature, a 1,3-dipolar cycloaddition with dialkyl acetylenedicarboxylates 1a,b to generate furan-derived short-lived intermediates 2, which can be trapped by two additional equivalents of 1a,b or ...
Klaus Banert, Sandra Bochmann, Andreas Ihle, Oliver Plefka, Florian Taubert, Tina Walther, Marcus Korb, Tobias Rüffer, Heinrich Lang   +8 more
doaj   +1 more source

1,3‐Dipolar Cycloaddition of Dipolar Reagents to Bis(styryl) Sulfones.

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
V. Padmavathi, K. Venugopal Reddy, A. Balaiah, T. V. Ramana Reddy, D. Bhaskar Reddy   +4 more
openaire   +1 more source

Peptide Terminated Polymer Brush Nanomaterials for Label‐Free Separation of Cancer Cells Based on Relative Adhesion

Small, EarlyView.
Horan et al. demonstrate that RGD peptide‐functionalized poly(ethylene glycol) brush films synthesized in polydimethylsiloxane microfluidic channels by surface‐initiated atom transfer radical polymerization enable label‐free separation of melanoma and ovarian cancer cells based on differential integrin expression.
Stephen Horan, Anita Wdowicz, Nathan Feely, Peng Li, Oya Tagit, Wenxin Wang, Gil U Lee   +6 more
wiley   +1 more source

New Quinazolin-4(3H)-One Derivatives Incorporating Isoxazole Moiety as Antioxidant Agents: Synthesis, Structural Characterization, and Theoretical DFT Mechanistic Study

Pharmaceuticals
Background: This research centers on the development and spectroscopic characterization of new quinazolin-4(3H)-one-isoxazole derivatives (5a–e). The aim was to investigate the regioselectivity of the 1,3-dipolar cycloaddition involving arylnitriloxides ...
Yassine Rhazi, Riham Sghyar, Noemi Deak, Bouchra Es-Sounni, Bouchra Rossafi, Albert Soran, Mustapha Laghmari, Azize Arzine, Asmae Nakkabi, Khalil Hammani, Samir Chtita, Mohammed M. Alanazi, Gabriela Nemes, Mohamed El. Yazidi   +13 more
doaj   +1 more source

5-Benzoyl-N,4-diphenyl-4,5-dihydro-1H-pyrazole-3-carboxamide

Acta Crystallographica Section E, 2009
The title compound, C23H19N3O2, was synthesized by the 1,3-dipolar cycloaddition reaction of N-phenyl-α-diazoacetamide and chalcone. In the molecule, the pyrazoline ring assumes an envelope conformation.
Long He
doaj   +1 more source

High‐performance electro‐optic materials featuring enhanced thermal stability through dual‐donor structural crosslinking engineering

Smart Molecules, EarlyView.
A groundbreaking dual‐donor crosslinking strategy was reported to significantly enhance the thermal stability, achieving remarkable EO coefficients (257–301 pm/V), glass transition temperatures (Tg) ranging from 107–187°C, and ultrahigh chromophore densities (3.73–4.26 × 10²⁰ molecules/cm³) with exceptional long‐term stability after 500 h at 85°C ...
Yu Zhang, Ziyun Zheng, Zhihan Huang, Zhifan Liu, Youling Chen, Fuyang Huo, Fenggang Liu, Xiubin Xu   +7 more
wiley   +1 more source

An overview of the cycloaddition chemistry of fulvenes and emerging applications

Beilstein Journal of Organic Chemistry, 2019
The unusual electronic properties and unique reactivity of fulvenes have interested researchers for over a century. The propensity to form dipolar structures at relatively low temperatures and to participate as various components in cycloaddition ...
Ellen Swan, Kirsten Platts, Anton Blencowe   +2 more
doaj   +1 more source

Ultrasound-promoted synthesis of novel fused heterocycles by criss-cross cycloaddition

Journal of Saudi Chemical Society, 2016
This work reports a novel and highly efficient methodology for the synthesis of perhydrotriazolotriazoledithions from two successive 1,3-dipolar cycloaddition under ultrasound irradiation.
Javad Safari, Soheila Gandomi-Ravandi, Marzieh Ghotbinejad   +2 more
doaj   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source