Hydrochlorothiazide/Losartan Potassium Tablet Prepared by Direct Compression [PDF]
Pharmaceutics, 2022 Hydrochlorothiazide (HCTZ)/losartan potassium (LOS-K) was used as a model drug to prepare compound tablets through the investigation of the compression and mechanical properties of mixed powders to determine the formulation and preparation factors ...
Qiuhua Luo, Qianying Zhang, Puxiu Wang
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SeDeM as a Tool to Validate Drug Substance Manufacturing Processes and Assess Scalability and Suitability for Direct Compression: Supplier Screening [PDF]
Pharmaceutics, 2023 During the development of an oral solid form of a drug substance, a thorough understanding of the critical material attributes is necessary, as the physical properties of the active pharmaceutical ingredient (API) can profoundly influence the drug ...
Alba Figuera-Figuera +5 more
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Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting Process [PDF]
Pharmaceutics, 2023 Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control.
Gerald A. Hebbink +7 more
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Modelling the Compaction Step of a Platform Direct Compression Process [PDF]
Pharmaceutics, 2022 The ability to predict formulation behaviour at production scale during formulation design can reduce the time to market and decrease product development costs.
Raghu V. G. Peddapatla +10 more
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Comparative Evaluation of the Powder and Tableting Properties of Regular and Direct Compression Hypromellose from Different Vendors [PDF]
Pharmaceutics, 2023 Hypromellose, a widely used polymer in the pharmaceutical industry, is available in several grades, depending on the percentage of substitution of the methoxyl and hydroxypropyl groups and molecular weight, and in various functional forms (e.g., suitable
Nihad Mawla +8 more
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Process Model Approach to Predict Tablet Weight Variability for Direct Compression Formulations at Pilot and Production Scale [PDF]
Pharmaceutics, 2021 Optimizing processing conditions to achieve a critical quality attribute (CQA) is an integral part of pharmaceutical quality by design (QbD). It identifies combinations of material and processing parameters ensuring that processing conditions achieve a ...
Raghu V. G. Peddapatla +9 more
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Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in a Continuous Direct Compression Line [PDF]
Pharmaceutics, 2022 The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line.
Marius J. Kreiser +2 more
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Understanding the Performance of a Novel Direct Compression Excipient Comprising Roller Compacted Chitin [PDF]
Marine Drugs, 2020 Chitin has been investigated in the context of finding new excipients suitable for direct compression, when subjected to roller compaction. Ball milling was concurrently carried out to compare effects from different energy or stress-inducing techniques ...
Deeb Abu Fara +4 more
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Novel Bioequivalent Tablet of Solifenacin Succinate Prepared Using Direct Compression Technique for Improved Chemical Stability [PDF]
Pharmaceutics, 2023 We designed a bioequivalent tablet form of solifenacin succinate (SOL) with an improved storage stability using a direct compression (DC) technique. An optimal direct compressed tablet (DCT) containing an active substance (10 mg), lactose monohydrate ...
Do Hwan Kim +3 more
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Formulation Study of a Co-Processed, Rice Starch-Based, All-in-One Excipient for Direct Compression Using the SeDeM-ODT Expert System [PDF]
Pharmaceuticals, 2021 A co-processed, rice starch-based excipient (CS), previously developed and shown to exhibit good pharmaceutical properties, is investigated as an all-in-one excipient for direct compression (DC).
Karnkamol Trisopon +3 more
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