Results 71 to 80 of about 633,663 (306)
Direct Feedback Learning With Local Alignment Support
IEEE AccessWhile backpropagation (BP) algorithm has been pivotal in enabling the success of modern deep learning technologies, it encounters challenges related to computational inefficiency and biological implausibility.
Heesung Yang, Soha Lee, Hyeyoung Park
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Systematic Direct Observation of Clinical Skills in the Clinical Year
MedEdPORTAL, 2014 Introduction Direct observation of clinical skills is vital to medical student development. However, direct observation of medical students by faculty is often sporadic, undocumented, and unstandardized.
Jocelyn Schiller +9 more
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Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Nonlinear Output Feedback Control: An Analysis of Performance and Robustness [PDF]
, 2004 By considering a non-singular performance cost functional, observer backstepping designs and adaptive observer backstepping designs are compared to high-gain observer designs for an output feedback system and a parametric output feedback system.
Xie, Chengkang
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Providing effective feedback on whole-phrase input in computer-assisted language learning [PDF]
, 2008 An important advantage of online assessment work is that answer data can be easily stored and later analysed with a view to establishing the efficacy of the assessment methodology.
Fowler, Alison M.L. +1 more
core
, 2023 Empirical data on automated writing evaluation (AWE) has been accumulating over the past several years, but previous research has concentrated on the impact of using machine feedback alone, and only a little is known about how learners view the usage of ...
Tomoyuki Kawashima, Kawashima, Tomoyuki
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Feedback arcs and node hierarchy in directed networks [PDF]
Chinese Physics B, 2017 Directed networks such as gene regulation networks and neural networks are connected by arcs (directed links). The nodes in a directed network are often strongly interwound by a huge number of directed cycles, which lead to complex information-processing dynamics in the network and make it highly challenging to infer the intrinsic direction of ...
Jin Hua Zhao, Hai-Jun Zhou
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source