Results 81 to 90 of about 4,702,853 (289)

Systematic Direct Observation of Clinical Skills in the Clinical Year

open access: yesMedEdPORTAL, 2014
Introduction Direct observation of clinical skills is vital to medical student development. However, direct observation of medical students by faculty is often sporadic, undocumented, and unstandardized.
Jocelyn Schiller   +9 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Tool for Documenting Clinical Point-of-Care Direct Observation and Formative Feedback

open access: yesMedEdPORTAL, 2015
Introduction Formative feedback during patient encounters (point-of-care) is valuable for the development of learner clinical skills since students can address gaps identified in history taking or physical exam skills, and faculty are more likely to ...
Sangeeta Lamba, Roxanne Nagurka
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Global and regional importance of the direct dust-climate feedback

open access: yesNature Communications, 2018
Feedbacks between desert dust and climate might have amplified past climate changes, yet their role in future climate change is unclear. Here the authors find that dust feedbacks could play a key role in the future climates of Northern Africa, the Sahel,
Jasper F. Kok   +3 more
doaj   +1 more source

Message Framing Influences Perceptions of Feedback (In)directness

open access: yesSocial Cognition, 2018
Communication varies in indirectness, influencing the effectiveness of the message as well as interpersonal dynamics. However, this issue was not studied empirically in the feedback literature. Integrating communication indirectness and message framing theories, we propose that whether success and failure feedback are framed as a negation (non-losses ...
Franki Y. H. Kung, Abigail Scholer
openaire   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

THE EFFECT OF INDIRECT CODED FEEDBACK ON STUDENTS’ WRITING ABILITY

open access: yesOkara: Jurnal Bahasa dan Sastra, 2017
The purpose of this research is to know whether indirect coded feedback gives a better effect on students’ writing ability rather than direct feedback. the design used in this experimental research was randomized group post test only design.
Sri Nurhayati
doaj   +1 more source

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