Results 191 to 200 of about 721,346 (281)

Direct RNA sequencing reveals multilayered epitranscriptomic remodeling in macrophages upon Mtb infection. [PDF]

Front Cell Infect Microbiol
Zou RC, Su K, Wei D, Wang Q, Tang B, Wang T, Wang L, Chen P, Wu T, Yang X.   +9 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Ab initio detection of multiple epitranscriptomic modifications from Oxford nanopore technology direct RNA sequencing data. [PDF]

Brief Bioinform
Fonzino A, Fosso B, Visci G, Gissi C, Pesole G, Picardi E.   +5 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Direct RNA sequencing enables improved transcriptome assessment and tracking of RNA modifications for medical applications. [PDF]

Nucleic Acids Res
Hewel C, Wierczeiko A, Miedema J, Friedrich J, Hofmann F, Weißbach S, Dietrich V, Holthöfer L, Haug V, Mündnich S, Schartel L, Lehmann L, Jensen KL, Diederich S, Sys S, Butto T, Paul NW, Koch J, Lyko F, Kraft F, Russo A, Schweiger S, Lemke EA, Helm M, Linke M, Gerber S.   +25 more
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing. [PDF]

Front Genet
Liao Y, Ding Z, Chen X, Yin C, Yang B, Yang Q, Xing Y.   +6 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Nanopore direct RNA sequencing reveals METTL2A-mediated m³C sites in poly(A) RNA. [PDF]

Genome Res
Mitsutomi S, Sugawara A, Seki M, Suzuki Y, Miyao S, Du H, Takahashi K, Mizukami Y, Taniue K, Akimitsu N.   +9 more
europepmc   +1 more source