Results 91 to 100 of about 1,372,167 (289)

Directed Fixed Energy Sandpile Model

, 2004
We numerically study the directed version of the fixed energy sandpile. On a closed square lattice, the dynamical evolution of a fixed density of sand grains is studied.
A. Bershadskii, A. E. Scheidegger, F. Bagnoli, H. Leschhorn, M. De Menech, P. Bak, P. Fröjdh, P. Grassberger, R. Karmakar, R. Pastor-Satorras, S. S. Manna, W. Kinzel   +11 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Rescue of conformational dynamics in enzyme catalysis by directed evolution

Nature Communications, 2018
A key challenge in the field of protein design and evolution is to understand the mechanisms by which directed evolution is improving enzymes. Here the authors combine different biophysical methods and give mechanistic insights into how directed ...
Renee Otten, Lin Liu, Lillian R. Kenner, Michael W. Clarkson, David Mavor, Dan S. Tawfik, Dorothee Kern, James S. Fraser   +7 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Natural Selection of Paths in Networks [PDF]

, 2011
We present a novel algorithm that exhibits natural selection of paths in a network. If each node and weighted directed edge has a unique identifier, a path in the network is defined as an ordered list of these unique identifiers.
Chrisantha Fernando, Eö, Philip Husbands, Vera Vasas   +3 more
core   +2 more sources

Correlated Initial Conditions in Directed Percolation

, 1998
We investigate the influence of correlated initial conditions on the temporal evolution of a (d+1)-dimensional critical directed percolation process. Generating initial states with correlations ~r^(sigma-d) we observe that the density of active sites in ...
A. J. Bray, B. P. Lee, E. Domany, Géza Ódor, H. K. Janssen, H. K. Janssen, Haye Hinrichsen, I. Jensen, I. Jensen, J. F. F. Mendes, J. L. Cardy, L. Peliti, M. Doi, M. Henkel, P. Grassberger, P. Grassberger, P. Grassberger, P. Grassberger, W. Kinzel   +18 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Directed evolution of CRISPR-Cas9 to increase its specificity

Nature Communications, 2018
Undesired off-target effects can hamper the use of CRISPR-Cas9 in therapeutic applications. Here the authors use a directed evolution approach to develop Sniper-Cas9 which combines high specificity with no loss of on-target activity.
Jungjoon K. Lee, Euihwan Jeong, Joonsun Lee, Minhee Jung, Eunji Shin, Young-hoon Kim, Kangin Lee, Inyoung Jung, Daesik Kim, Seokjoong Kim, Jin-Soo Kim   +10 more
doaj   +1 more source

Anisotropic flow of strange particles at RHIC

, 2005
Space-time picture of the anisotropic flow evolution in Au+Au collisions at BNL RHIC is studied for strange hadrons within the microscopic quark-gluon string model.
Amand Faessler, Bravina L V, Bravina L V, C Fuchs, E E Zabrodin, G Burau, L Bleibel, L V Bravina, Ritter H G, Tonjes M B   +9 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source