Results 31 to 40 of about 1,372,167 (289)
Laboratory-Directed Protein Evolution [PDF]
Microbiology and Molecular Biology Reviews, 2005 SUMMARYSystematic approaches to directed evolution of proteins have been documented since the 1970s. The ability to recruit new protein functions arises from the considerable substrate ambiguity of many proteins. The substrate ambiguity of a protein can be interpreted as the evolutionary potential that allows a protein to acquire new specificities ...
Ling, Yuan +3 more
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Directed evolution converts subtilisin E into a functional equivalent of thermitase [PDF]
, 1999 We used directed evolution to convert Bacillus subtilis subtilisin E into an enzyme functionally equivalent to its thermophilic homolog thermitase from Thermoactinomyces vulgaris.
Arnold, Frances H., Zhao, Huimin
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F1000Research, 2015 In prokaryotes, horizontal gene transfer (HGT) has been regarded as an important evolutionary drive to acquire and retain beneficial genes for their survival in diverse ecologies.
Punita Sharma +11 more
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PAIDDE: A Permutation-Archive Information Directed Differential Evolution Algorithm
IEEE Access, 2022 Evolutionary algorithms have shown great successes in various real-world applications ranging in molecule to astronomy. As a mainstream evolutionary algorithm, differential evolution (DE) possesses the characteristics of simple algorithmic structure ...
Xiaosi Li +5 more
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Quantum causal histories [PDF]
, 1999 Quantum causal histories are defined to be causal sets with Hilbert spaces attached to each event and local unitary evolution operators. The reflexivity, antisymmetry, and transitivity properties of a causal set are preserved in the quantum history as ...
Ambjorn J +16 more
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Directing evolution in cells [PDF]
Nature Methods, 2020 A CRISPR–Cas9-based approach generates libraries of mutant proteins targeted to specific subcellular compartments for in situ directed evolution.
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Directed Evolution and Biocatalysis [PDF]
Angewandte Chemie International Edition, 2001 This review describes the current state of biocatalysis in the chemical industry. Although we recognize the advantages of chemical approaches, we suggest that the use of biological catalysis is about to expand dramatically because of the recent developments in the artificial evolution of genes that code for enzymes. For the first time it is possible to
Keith A., Powell +6 more
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A New Evolution Model for Weighted Directed Networks
Xibei Gongye Daxue Xuebao, 2020 The most of the recent models of directed weighted network evolution capture the growth process based on two conventional assumptions: constant average degree assumption and slowly growing diameter assumption.
doaj +1 more source
Catalysts on Demand: Selective Oxidations by Laboratory-Evolved Cytochrome P450 BM3 [PDF]
, 2009 Efficient catalysts for selective oxidation of C-H bonds using atmospheric oxygen are highly desirable to decrease the economic and environmental costs associated with conventional oxidation processes.
Arnold, Frances H., Lewis, Jared C.
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Quantifying the Performance of Micro-Compartmentalized Directed Evolution Protocols
Life, 2020 High-throughput, in vitro approaches for the evolution of enzymes rely on a random micro-encapsulation to link phenotypes to genotypes, followed by screening or selection steps.
Adèle Dramé-Maigné +3 more
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