Results 41 to 50 of about 1,372,167 (289)

Directed Percolation Universality in Asynchronous Evolution of Spatio-Temporal Intermittency

open access: yes, 1997
We present strong evidence that a coupled-map-lattice model for spatio-temporal intermittency belongs to the universality class of directed percolation when the updating rules are asynchronous, i.e.
Bohr, Tomas   +2 more
core   +2 more sources

Towards the Directed Evolution of Hybrid Catalysts

open access: yesCHIMIA, 2002
The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and ...
Manfred T. Reetz   +3 more
doaj   +1 more source

Machine learning-guided directed evolution for protein engineering [PDF]

open access: yes, 2019
Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H.   +2 more
core   +1 more source

Directed percolation depinning models: Evolution equations

open access: yes, 1999
We present the microscopic equation for the growing interface with quenched noise for the model first presented by Buldyrev et al. [Phys. Rev. A 45, R8313 (1992)]. The evolution equation for the height, the mean height, and the roughness are reached in a
A. Díaz-Sánchez   +11 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen   +23 more
wiley   +1 more source

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender   +17 more
wiley   +1 more source

Directed cycles and related structures in random graphs: II--Dynamic properties

open access: yes, 2003
We study directed random graphs (random graphs whose edges are directed) as they evolve in discrete time by the addition of nodes and edges. For two distinct evolution strategies, one that forces the graph to a condition of near acyclicity at all times ...
Albert   +8 more
core   +1 more source

Programming temporal morphing of self-actuated shells [PDF]

open access: yes, 2020
Advances in shape-morphing materials, such as hydrogels, shape-memory polymers and light-responsive polymers have enabled prescribing self-directed deformations of initially flat geometries.
Bickel, Bernd   +4 more
core   +3 more sources

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers   +5 more
wiley   +1 more source

Directed Chemical Evolution with an Outsized Genetic Code. [PDF]

open access: yesPLoS ONE, 2016
The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark   +3 more
doaj   +1 more source

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