Results 51 to 60 of about 1,372,167 (289)
A C35 Carotenoid Biosynthetic Pathway [PDF]
, 2003 Upon coexpression with Erwinia geranylgeranyldiphosphate (GGDP) synthase in Escherichia coli, C30 carotenoid synthase CrtM from Staphylococcus aureus produces novel carotenoids with the asymmetrical C35 backbone.
Arnold, Frances H., Umeno, Daisuke
core
Dynamical Networks in Function Dynamics [PDF]
, 2002 As a first step toward realizing a dynamical system that evolves while spontaneously determining its own rule for time evolution, function dynamics (FD) is analyzed.
Albert +7 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Oncolytic Viruses: The Power of Directed Evolution
Advances in Virology, 2012 Attempts at developing oncolytic viruses have been primarily based on rational design. However, this approach has been met with limited success. An alternative approach employs directed evolution as a means of producing highly selective and potent ...
Maxine Bauzon, Terry W. Hermiston
doaj +1 more source
Directed evolution strategies for improved enzymatic performance
Microbial Cell Factories, 2005 The engineering of enzymes with altered activity, specificity and stability, using directed evolution techniques that mimic evolution on a laboratory timescale, is now well established.
Dalby Paul A, Hibbert Edward G
doaj +1 more source
Poincar\'{e} cycle of a multibox Ehrenfest urn model with directed transport
, 2002 We propose a generalized Ehrenfest urn model of many urns arranged periodically along a circle. The evolution of the urn model system is governed by a directed stochastic operation.
A. Lipowski +14 more
core +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa +3 more
wiley +1 more source
Design and directed evolution of noncanonical β-stereoselective metalloglycosidases
Nature Communications, 2022 Metallohydrolases are ubiquitous enzymes. Here the authors show the design and biochemical characterisation of metalloglycosidase by constructing a hydrolytically active Zn-binding site within a barrel-shaped outer membrane protein OmpF.
Woo Jae Jeong, Woon Ju Song
doaj +1 more source
Multiple scale theory of topology driven pattern on directed networks [PDF]
, 2015 Dynamical processes on networks are currently being considered in different domains of cross-disciplinary interest. Reaction-diffusion systems hosted on directed graphs are in particular relevant for their widespread applications, from neuroscience, to ...
Contemori, Silvia +3 more
core +2 more sources
Directed Evolution of Microbial Communities
Annual Review of Biophysics, 2020 Directed evolution is a form of artificial selection that has been used for decades to find biomolecules and organisms with new or enhanced functional traits. Directed evolution can be conceptualized as a guided exploration of the genotype–phenotype map, where genetic variants with desirable phenotypes are first selected and then mutagenized to search ...
Rebolleda-Gomez, Maria +5 more
openaire +6 more sources