Results 31 to 40 of about 495,896 (276)
Directed evolution converts subtilisin E into a functional equivalent of thermitase [PDF]
, 1999 We used directed evolution to convert Bacillus subtilis subtilisin E into an enzyme functionally equivalent to its thermophilic homolog thermitase from Thermoactinomyces vulgaris.
Arnold, Frances H., Zhao, Huimin
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STAR Protocols, 2022 Summary: Systematic evolution of ligands by exponential enrichment (SELEX) encompasses a wide variety of high-throughput screening techniques for producing nucleic acid binders to molecular targets through directed evolution.
Zachary William Cutts +7 more
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Molecules, 2023 The combination of wet-lab experimental data on multi-site combinatorial mutations and machine learning is an innovative method in protein engineering. In this study, we used an innovative sequence-activity relationship (innov’SAR) methodology based on ...
Gaolin Li +4 more
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Towards active microfluidics: Interface turbulence in thin liquid films with floating molecular machines [PDF]
, 2008 Thin liquid films with floating active protein machines are considered. Cyclic mechanical motions within the machines, representing microscopic swimmers, lead to molecular propulsion forces applied to the air-liquid interface. We show that, when the rate
Alexander S. Mikhailov +2 more
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Directional mutation pressure and neutral molecular evolution. [PDF]
Proceedings of the National Academy of Sciences, 1988 A quantitative theory of directional mutation pressure proposed in 1962 explained the wide variation of DNA base composition observed among different bacteria and its small heterogeneity within individual bacterial species. The theory was based on the assumption that the effect of mutation on a genome is not random but has a directionality toward ...
openaire +2 more sources
Viruses, 2022 Coronaviruses (CoVs) constitute a large and diverse subfamily of positive-sense single-stranded RNA viruses. They are found in many mammals and birds and have great importance for the health of humans and farm animals. The current SARS-CoV-2 pandemic, as
Grigorios D. Amoutzias +5 more
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Structure-Guided Recombination Creates an Artificial Family of Cytochromes P450 [PDF]
, 2006 Creating artificial protein families affords new opportunities to explore the determinants of structure and biological function free from many of the constraints of natural selection.
Arnold, Frances H. +5 more
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Information content of colored motifs in complex networks [PDF]
, 2011 We study complex networks in which the nodes of the network are tagged with different colors depending on the functionality of the nodes (colored graphs), using information theory applied to the distribution of motifs in such networks.
Arend Hintze +4 more
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A model for the emergence of cooperation, interdependence and structure in evolving networks
, 2000 Evolution produces complex and structured networks of interacting components in chemical, biological, and social systems. We describe a simple mathematical model for the evolution of an idealized chemical system to study how a network of cooperative ...
Bak +8 more
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Graph Theory and Networks in Biology [PDF]
, 2006 In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to ...
Mason, Oliver, Verwoerd, Mark
core +3 more sources