Results 11 to 20 of about 31,873 (244)

Exploring the Pharmacological Potential of Carrageenan Disaccharides as Antitumor Agents: An In Silico Approach

Marine Drugs
Carrageenans have demonstrated enhanced antitumor activity upon depolymerization into disaccharides. However, the pharmacological viability of these disaccharides and their mechanisms of antitumor action remains to be fully elucidated.
Ohana Leticia Tavares Silva, Monique Gabriela das Chagas Faustino Alves, Hugo Alexandre Oliveira Rocha   +2 more
doaj   +2 more sources

Rifaximin versus Nonabsorbable Disaccharides for the Treatment of Hepatic Encephalopathy: A Meta-Analysis [PDF]

Gastroenterology Research and Practice, 2013
Background. Many studies have found that the antibiotic rifaximin is effective for the treatment of hepatic encephalopathy. However, there is no uniform view on the efficacy and safety of rifaximin. Methods.
Dong Wu, Shu-Mei Wu, Jie Lu, Ying-Qun Zhou, Ling Xu, Chuan-Yong Guo   +5 more
doaj   +2 more sources

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond-Specific Microbial Responders. [PDF]

Adv Sci (Weinh)
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Lu X, Zou J, Han G, Zhao M, Luo T, Feng X, Zhu L, Chen Y, Ji X, Jin J, Zhao L.   +10 more
europepmc   +2 more sources

Nitrone Cycloadditions to Isolevoglucosenone:  Ready Access to a New Class of Directly Linked (1→3)-Imino-C-disaccharides

, 2016
Straightforward access to a new class of d-gulo- and d-allo-derived directly linked (1→3)-imino-C-disaccharides by means of cycloaddition reactions of enantiopure polyhydroxylated pyrroline N-oxides with isolevoglucosenone is reported.
Andrea Goti (1546123), Alberto Brandi (310899), Francesca Cardona (310895)   +2 more
core   +3 more sources

Developing a Library of Mannose-Based Mono- and Disaccharides: A General Chemoenzymatic Approach to Monohydroxylated Building Blocks

Molecules, 2020
Regioselective deprotection of acetylated mannose-based mono- and disaccharides differently functionalized in anomeric position was achieved by enzymatic hydrolysis.
Lisa Tanzi, Marina Simona Robescu, Sara Marzatico, Teresa Recca, Yongmin Zhang, Marco Terreni, Teodora Bavaro   +6 more
doaj   +1 more source

Efficient Synthesis of Rare Disaccharides by Engineered β-Glucosidase Based on Hydropathy Index [PDF]

, 2020
Oligosaccharides have important therapeutic applications. A useful route for oligosaccharides synthesis, especially rare disaccharides, is reverse hydrolysis by β-glucosidase.
Zhengyao, Liu, Daming, Gao, Zhiqiang, Du, Kangle, Niu, Zhenzhen, Wang, Xu, Fang, Yuhui, Feng, Tianlong, Gao, Piaopiao, Zhang   +8 more
core   +2 more sources

1D 13C-NMR Data as Molecular Descriptors in Spectra — Structure Relationship Analysis of Oligosaccharides

Molecules, 2012
Spectra-structure relationships were investigated for estimating the anomeric configuration, residues and type of linkages of linear and branched trisaccharides using 13C-NMR chemical shifts.
Florbela Pereira
doaj   +1 more source

3-Exomethylene Sialic Acid Disaccharides as Substrate-Type Mechanism-Based Sialidase Inhibitors [PDF]

, 2022
We designed α(2,3)- and α(2,6)-sialylgalactose analogues bearing an exomethylene unit at C3 of sialic acid (3-exoSia) as a novel type of mechanism-based inhibitors of sialidases.
Taeko , Miyagi, Keiya , Uezono, Risa , Maeda, Masaki , Morita, Kana , Oonuma, Ryo , Fukazawa, Mikiko, Sodeoka, Marie, Kato, Hiroyuki , Koshino, Go, Hirai, Mikiko Sodeoka, Keiya Uezono, Kana Oonuma, Hiroyuki Koshino, Go Hirai, Marie Kato, Risa Maeda, Ryo Fukazawa, Masaki Morita, Taeko Miyagi   +19 more
core   +2 more sources

Relationship between GC/EI-qMS disaccharide profiles and corresponding genomes of wheat, rye and triticale cultivars [PDF]

Ratarstvo i Povrtarstvo, 2017
Cultivars of small grain species: wheat (Triticum aestivum), rye (Secale cereale) and triticale (Triticosecale) were selected because of their specific biochemical composition of carbohydrates for gas chromatographic analysis.
Pastor Kristian, Ačanski Marijana, Vujić Đura, Kondić-Špika Ankica   +3 more
doaj   +1 more source

Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC

Hepatology, EarlyView., 2022
Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu, Bingqing Xu, Xiaodong Wang, Wen‐Hua Wan, Jinying Lu, Deyuan Kong, Yu Jin, Wenhua You, Hua Sun, Xiaoxin Mu, Dongju Feng, Yun Chen   +11 more
wiley   +1 more source