Results 71 to 80 of about 75,371 (302)

A Cryoprotectant‐Compatible Nanoporous Platform for Stable and Scalable Delivery of Biopharmaceuticals

Advanced Materials, EarlyView.
A cryoprotectant‐compatible nanoporous platform enables ambient‐stable and scalable delivery of gene editing therapeutics. By combining hierarchical pore architecture with optimized lyophilization chemistry, the system preserves Cas9‐RNP activity post‐freeze‐drying.
Sian Lee, Seongchan Kim, Jooyeun Chong, Min‐gyeong Kim, Kayeong Lim, Nan‐Ee Lee, Jahyun Koo, Jiheong Kang, Hyojin Lee   +8 more
wiley   +1 more source

The regulatory and transcriptional landscape associated with carbon utilization in a filamentous fungus. [PDF]

, 2020
Filamentous fungi, such as Neurospora crassa, are very efficient in deconstructing plant biomass by the secretion of an arsenal of plant cell wall-degrading enzymes, by remodeling metabolism to accommodate production of secreted enzymes, and by enabling ...
Benz, J Philipp, Blow, Matthew J, Calhoun, Sara, Dietschmann, Axel, Glass, N Louise, Grigoriev, Igor V, Huberman, Lori B, Kowbel, David J, Lee, Juna, Lipzen, Anna, Monti, Remo, O'Malley, Ronan C, Singan, Vasanth R, Thieme, Nils, Wu, Vincent W, Xiong, Yi   +15 more
core   +3 more sources

Modified Bleomycin Disaccharides Exhibiting Improved Tumor Cell Targeting

Biochemistry, 2014
The bleomycins (BLMs) are a family of antitumor antibiotics used clinically for anticancer chemotherapy. Their antitumor selectivity derives at least in part from their ability to target tumor cells, a property that resides in the carbohydrate moiety of ...
M. M. Madathil, Chandrabali Bhattacharya, Zhiqiang Yu, Rakesh Paul, M. J. Rishel, S. Hecht   +5 more
semanticscholar   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

Structural Insights Into Man9 Recognition by the HIV Antibody 2G12 Revealed by Paramagnetic NMR

Advanced Science, EarlyView.
The HIV gp120 glycoprotein displays Man9 oligomannose structures that are recognized by the neutralizing antibody 2G12. Detailed characterization of the binding epitope in solution is important for immunogen design but remains challenging, since the signals of the terminal mannoses from the three arms of Man9 (D1, D2, and D3) cannot be distinguished in
Adrián Silva‐Díaz, Paola Oquist‐Phillips, Noelia de la Cruz, Inés Lera‐Lasso, Laura Castañar, Javier Rojo, Javier Ramos‐Soriano, Ángeles Canales   +7 more
wiley   +1 more source

Carbohydrate Intake in the Etiology of Crohn's Disease and Ulcerative Colitis [PDF]

, 2014
Background: Diet may have a role in the etiology of inflammatory bowel disease. In previous studies, the associations between increased intakes of carbohydrates, sugar, starch, and inflammatory bowel disease are inconsistent.
Abraham, Amre, Andrew R. Hart, Anja Olsen, Anne Tjonneland, Antoine Racine, Antonia Trichopoulou, Bas Oldenburg, Bennett, Bernstein, Bianchi Porro, Bingham, Bohlscheid-Thomas, Calkins, Chan, Darmon, De Filippo, Domenico Palli, Essebag, Fiona van Schaik, Francesca L. Crowe, Franck Carbonnel, Gaboriau-Routhiau, Geerling, Giovanna Masala, Göran Hallmans, H. Bas Bueno-de-Mesquita, Hart, Heresbach, Hou, Iwaya, Jantchou, Jarnerot, Jostins, Kaaks, Kasper, Katsouyanni, Kay-Tee Khaw, Kim Overvad, Kurakevich, Kurata, Maconi, Manuela M. Bergmann, Margetts, Marie-Christine Boutron-Ruault, Martinez-Medina, Maslowski, Mendall, Moreno-Navarrete, Ocke, Olof Grip, Orholm, Peeters, Persson, Pisani, Pontus Karling, Poullis, Prynne, Quezada, Reif, Riboli, Riboli, Robert Luben, Rosario Tumino, Rudolf Kaaks, Sakamoto, Sartor, Satsangi, Shivananda, Silkoff, Simon S. M. Chan, Slimani, Sonnenberg, Spooren, Stefan Lindgren, Thia, Thornton, Timothy Key, Tjonneland, Tragnone, Turnbaugh, van Liere, Wen, Zhang   +83 more
core   +1 more source

Metabolomic Analysis Reveals Contributions of Citric and Citramalic Acids to Rare Earth Bioleaching by a Paecilomyces Fungus. [PDF]

, 2019
Conventional methods for extracting rare earth elements from monazite ore require high energy inputs and produce environmentally damaging waste streams. Bioleaching offers a potentially more environmentally friendly alternative extraction process.
Alvarez-Cohen, Lisa, Brisson, Vanessa L, Zhuang, Wei-Qin   +2 more
core   +1 more source

The Critical Role of Fractionated Urine Glycosaminoglycans in the Evaluation of Mucopolysaccharidosis Type II in Four Unrelated Families

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Since 2015, Ann and Robert H. Lurie Children's Hospital has performed diagnostic testing for infants who screen positive for mucopolysaccharidosis type II (MPS II) on the Illinois newborn screen. Preliminary diagnostic testing includes measurement of plasma iduronate‐2‐sulfatase enzyme activity and urinary glycosaminoglycan analysis, followed ...
Carly A. Rasmussen, Monika Izdebski, Allison Paltzer, Rachel Hickey, Laura Pollard, Joshua Baker   +5 more
wiley   +1 more source

A method for characterising human intervertebral disc glycosaminoglycan disaccharides using liquid chromatography-mass spectrometry with multiple reaction monitoring [PDF]

European Cells & Materials, 2018
Intervertebral disc (IVD) degeneration results in the depletion of proteoglycans and glycosaminoglycans (GAGs), which can lead to structural and mechanical loss of IVD function, ingrowth of nociceptive nerve fibres and eventually discogenic pain ...
X Liu, D Krishnamoorthy, L Lin, P Xue, F Zhang, L Chi, RJ Linhardt, JC Iatridis   +7 more
doaj   +1 more source

Effect of buffer systems and disaccharides concentration on Podoviridae coliphage stability during freeze drying and storage.

Cryobiology, 2013
The aims of this study were to determine the stability of Podoviridae coliphage CA933P during lyophilization and storage in different media, and to establish similarities between the results obtained and those expected through mechanisms described for ...
C. Dini, P. J. de Urraza
semanticscholar   +1 more source