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The vertebral endplate: disc degeneration, disc regeneration [PDF]

European Spine Journal, 2006
The vertebral endplates are critical for maintaining disc function yet like other components of the disc are vulnerable to degeneration. This paper provides an overview of the development and normal function of the endplates as well as an impression of what happens when they undergo progressive degeneration.
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Intervertebral disc degeneration

European Spine Journal, 1993
Disc degeneration in the human spine is a complex phenomenon characterised by biochemical change in the nucleus pulposus and inner annulus and the formation of clefts and fissures radiating from the central area of the disc towards the periphery. In addition, and probably independent of these phenomena, discrete defects in the outer annular attachement
R D, Fraser, O L, Osti, B, Vernon-Roberts   +2 more
openaire   +2 more sources

Intervertebral disc degeneration

Nature Reviews Disease Primers
Intervertebral disc (IVD) degeneration is a naturally occurring process that is a consequence of biological ageing and exposure to normal physiological loading over a lifetime and is characterized by loss of IVD tissue structural integrity. The nucleus pulposus changes with loss of pressurization, decreased collagen concentration and loss of ...
Bradley T. Hammoor, Christopher S. Lai, Grace X. Xiong, Dawn M. Elliott, Brian Snyder, Edward Vresilovic, Christopher M. Bono, Benjamin R. Freedman   +7 more
openaire   +4 more sources

Extracellular Matrix in Disc Degeneration

Journal of Bone and Joint Surgery, 2006
The extracellular matrix of the intervertebral disc structures contains many molecules also found in cartilage. The extremely polyanionic proteoglycans play a central role, particularly in the nucleus, by creating an osmotic environment leading to retention of water and ensuing resistance to deformation-important for the resilience of the tissue ...
Haoyu, Feng, Mikael, Danfelter, Björn, Strömqvist, Dick, Heinegård   +3 more
openaire   +2 more sources

Genetics of Intervertebral Disc Degeneration

Current Osteoporosis Reports, 2023
Intervertebral disc degeneration is a contributor to chronic back pain. While a part of the natural aging process, early or rapid intervertebral disc degeneration is highly heritable. In this review, we summarize recent progress towards unraveling the genetics associated with this degenerative process.Use of large cohorts of patient data to conduct ...
David C. Ou-Yang, Christopher J. Kleck, Cheryl L. Ackert-Bicknell   +2 more
openaire   +2 more sources

Fundamentals of Intervertebral Disc Degeneration

World Neurosurgery, 2022
Lumbar disc degeneration is one of the leading causes of chronic low back pain. The degenerative cascade is often initiated by an imbalance between catabolic and anabolic processes in the intervertebral discs. As a consequence of extracellular matrix degradation, neoinnervation and neovascularization take place.
Sertac Kirnaz, Charisse Capadona, Taylor Wong, Jacob L. Goldberg, Branden Medary, Fabian Sommer, Lynn B. McGrath, Roger Härtl   +7 more
openaire   +2 more sources

Mechanobiology of the Intervertebral Disc and Relevance to Disc Degeneration

Journal of Bone and Joint Surgery, 2006
Mechanical loading of the intervertebral disc may contribute to disc degeneration by initiating degeneration or by regulating cell-mediated remodeling events that occur in response to the mechanical stimuli of daily activity. This article is a review of the current knowledge of the role of mechanical stimuli in regulating intervertebral disc cellular ...
Lori A, Setton, Jun, Chen
openaire   +2 more sources