Results 301 to 310 of about 118,573 (345)
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Lumbar Disc Degeneration: Epidemiology and Genetics
Journal of Bone and Joint Surgery, 2006Research conducted over the past decade has led to a dramatic shift in the understanding of disc degeneration and its etiology. Previously, heavy physical loading-often associated with occupation-was the main suspected risk factor for disc degeneration, which was commonly viewed as a wear-and-tear phenomenon exacerbated by the precarious nutritional ...
Michele C, Battié, Tapio, Videman
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Gene therapy for disc degeneration
Expert Opinion on Biological Therapy, 2007Recent advances in our understanding of the biology of the intervertebral disc have led to increased interest in the development of novel treatments of intervertebral disc degeneration. With the ability to provide sustained delivery of a potentially therapeutic agent, gene therapy has shown much promise in regard to the treatment of disc degeneration ...
Gianluca, Vadalà +2 more
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Discs Degenerate Before Facets
Spine, 1990The purpose of this study was to determine the relationship between facet joint osteoarthritis and disc degeneration in subjects in whom both MRI and CT scans had been obtained. The MRI scans were used to determine disc degeneration, the CT scans to determine facet joint osteoarthritis.
D, Butler +4 more
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Smoking and intervertebral disc degeneration
Medical Hypotheses, 2001Cigarette smokers have an increased risk of low back pain which may be caused by disc degeneration and spinal instability, for example. Ischemia, apoptosis, faulty synthesis of disc macromolecules, and an imbalance between disc matrix proteinases and their inhibitors may be involved in the pathogenesis of disc degeneration. Along with degeneration, the
R R, Fogelholm, A V, Alho
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Imaging Intervertebral Disc Degeneration
Journal of Bone and Joint Surgery, 2006Magnetic resonance imaging provides excellent anatomic detail of spinal tissues, but fails to provide the type of information that permits a definitive diagnosis in many patients with back pain. New imaging strategies that can be applied to the study of intervertebral disc degeneration include diffusion-weighted imaging, magnetic resonance imaging ...
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The pathophysiology of disc degeneration
The Journal of Bone and Joint Surgery. British volume, 2008The pathophysiology of intervertebral disc degeneration has been extensively studied. Various factors have been suggested as influencing its aetiology, including mechanical factors, such as compressive loading, shear stress and vibration, as well as ageing, genetic, systemic and toxic factors, which can lead to degeneration of the disc through ...
Hadjipavlou, A. G. +3 more
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Biologic Markers and Disc Degeneration
Journal of Bone and Joint Surgery, 2006Biomarkers of skeletal turnover, such as the synthesis and degradation of extracellular matrix molecules in specific tissues, offer the opportunity to gain new insights into spinal pathology and treatment. The creation, use, and interpretation of these analytical body-fluid measures of process (rather than outcome) require a clear understanding of the ...
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Genetics of the Degenerated Intervertebral Disc
World Neurosurgery, 2012Given the genetic and proteomic advances of the past decade, understanding of the molecular etiopathogenesis of several complex diseases is increasing. Intervertebral disc disease (IVDD) is no different from other complex diseases where both environmental and genetic constituents are considered causes.
Samuel, Kalb +4 more
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Disc degeneration in scheuermann disease
Skeletal Radiology, 1989Comparison of the radiographic signs of Scheuermann disease and the corresponding disc degeneration on thoracolumbar magnetic resonance (MR) images was made in 21 young patients. Marginal sclerosis, Schmorl nodes and narrowed disc spaces, but not irregular or wedge-shaped end-plates, were significantly associated with disc degeneration.
H, Paajanen +4 more
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Animal Models for Human Disc Degeneration
The Spine Journal, 2005Despite the significant impairment associated with degenerative disc disease, a clear understanding of its pathogenesis is still lacking. Currently, no particular model parallels the complex nature of human disc degeneration. Naturally occurring animal models have the drawback that the basis for the high rate of disc degeneration is not known. Although
Kern, Singh +2 more
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