Results 91 to 100 of about 193,025 (292)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
The promise of Synovial Joint-on-a-Chip in rheumatoid arthritis
Frontiers in ImmunologyRheumatoid arthritis (RA) affects millions of people worldwide, but there are limited drugs available to treat it, so acquiring a more comprehensive comprehension of the underlying reasons and mechanisms behind inflammation is crucial, as well as ...
Xin Zhang +21 more
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Gut Microbes, 2020 A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro.
Woojung Shin +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Advances in Microfluidic Cochlea‐On‐A‐Chip
Advanced ScienceThe current understanding of the human auditory system has been primarily based on studies using animal and cellular models. Organoids have been used to simulate cochlear structures and replicate cochlear functions.
Tian Shen +10 more
doaj +1 more source
Perspectives on organ-on-a-chip technology for natural products evaluation
Food & Medicine HomologyNatural products have always been a treasure trove for clinical drug development and a source of inspiration for lead compounds in the process of new drug discovery.
Xin Wang +5 more
doaj +1 more source
Designing Biomaterial Platforms for Cardiac Tissue and Disease Modeling
Advanced NanoBiomed Research, 2021 Heart disease is one of the leading causes of death in the world. There is a growing demand for in vitro cardiac models that can recapitulate the complex physiology of the cardiac tissue.
Andrew House +3 more
doaj +1 more source
A gut-brain axis on-a-chip platform for drug testing challenged with donepezil.
Lab on a ChipCurrent drug development pipelines are time-consuming and prone to a significant percentage of failure, partially due to the limited availability of advanced human preclinical models able to better replicate the in vivo complexity of our body.
F. Fanizza +8 more
semanticscholar +1 more source
Celiac disease-on-chip: Modeling a multifactorial disease in vitro
United European Gastroenterology journal, 2019 Conventional model systems cannot fully recapitulate the multifactorial character of complex diseases like celiac disease (CeD), a common chronic intestinal disorder in which many different genetic risk factors interact with environmental factors such as
R. Moerkens +3 more
semanticscholar +1 more source