A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip
Nature Biomedical Engineering, 2019 The diverse bacterial populations that comprise the commensal microbiome of the human intestine play a central role in health and disease. A method that sustains complex microbial communities in direct contact with living human intestinal cells and their
Sasan Jalili-Firoozinezhad +16 more
semanticscholar +1 more source
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Bone-on-a-Chip Systems for Hematological Cancers
BiosensorsHematological malignancies originating from blood, bone marrow, and lymph nodes include leukemia, lymphoma, and myeloma, which necessitate the use of a distinct chemotherapeutic approach.
Gül Kozalak, Ali Koşar
doaj +1 more source
Entwicklung von mikrofluidischen Multi-Organ-Zellchipsystemen für die in vitro Metabolisierung und Bestimmung der Toxizität von Substanzen [PDF]
, 2018 Die Entwicklung neuer Arzneistoffe ist ein langer und kostenintensiver Prozess. Verlässliche experimentelle Modelle zur präklinischen Testung während frühen Phasen der Arzneistoffentwicklung sind essenziell, um einem späteren Misserfolg vorzubeugen ...
Theobald, Jannick Florian
core +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
DEVELOPMENT OF HUMAN TISSUES ON A CHIP FROM PLURIPOTENT STEM CELLS [PDF]
, 2014 The development of new microscale technologies aimed at generating human tissues and organs on a chip is emerging as a novel effective strategy to perform cost effective and multi-parametric assays for disease modeling investigations and screening ...
Michielin, Federica
core +1 more source
Exploring Novel Materials To Be Used As Dual-Energy Mammography Contrast Agents For Breast Cancer Detection [PDF]
, 2022 Dual-energy mammography (DEM) is a recently FDA-approved x-ray imaging technology developed for breast cancer screening, especially advantageous for women with dense breasts.
Nieves Lopez, Lenitza
core +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Investigating the Impact of LncRNAs PUNISHER and GAS5 on the Pathogenesis of Calcific Aortic Valve Disease [PDF]
Calcific aortic valve disease (CAVD) is a progressive disorder marked by fibrosis and calcification of the aortic valve, lacking effective pharmacological treatment.
Zhou, Yuan
core
Nanoarchitectonics of Nanocellulose-Carbon Nanotube Composites : From Dispersion to Functional Structures [PDF]
, 2022 Väitöskirjatutkimuksessa pyrittiin selvittämään parametrejä ja ilmiöitä, mitkä vaikuttavat nanoselluloosa-hiilinanoputki (NC-CNT) komposiittien ominaisuuksiin mm. sähkönjohtavuuteen.
Siljander, Sanna
core