Results 41 to 50 of about 193,025 (292)

Classical Complement Pathway Inhibition in a “Human‐On‐A‐Chip” Model of Autoimmune Demyelinating Neuropathies [PDF]

, 2022
Chronic autoimmune demyelinating neuropathies are a group of rare neuromuscular disorders with complex, poorly characterized etiology. Here we describe a phenotypic, human-on-a-chip (HoaC) electrical conduction model of two rare autoimmune demyelinating ...
Alonso‐Alonso, Miguel, Atassi, Nazem, Chopra, Manisha, Emmett, Doug, Gable, Karissa L., Goswami, Arindom, Guptill, Jeffrey T., Hammond, Timothy, Hickman, James J., Hobson‐Webb, Lisa D., Howard, James F., Jackson, Max, Long, Christopher J., Lorance, Case, McAleer, Christopher W., Panicker, Sandip, Parry, Graham, Raja, Shruti M., Rumsey, John W., Russo, Melissa A., Sasserath, Trevor, Storek, Michael J.   +21 more
core   +2 more sources

A Comprehensive Review of Organ-on-a-Chip Technology and Its Applications

Biosensors
Organ-on-a-chip (OOC) is an emerging technology that simulates an artificial organ within a microfluidic cell culture chip. Current cell biology research focuses on in vitro cell cultures due to various limitations of in vivo testing.
Negar Farhang Doost, Soumya K. Srivastava   +1 more
doaj   +1 more source

Intestine‐on‐a‐chip for intestinal disease study and pharmacological research

View, 2023
Intestinal diseases seriously affect the quality of life. The assays for intestinal disease study based on two‐dimensional in vitro cell culture and animal models fail to model human physiology and pathophysiology accurately. As a bridge between in vitro
Dongxue Zhang, Liang Qiao
doaj   +1 more source

Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling

Frontiers in Bioengineering and Biotechnology
Organoids are stem-cell derived tissue structures mimicking specific structural and functional characteristics of human organs. Despite significant advancements in the field over the last decade, challenges like limited long-term functional culture and ...
Lito Papamichail, Lena S. Koch, D. Veerman, K. Broersen, A. D. van der Meer   +4 more
semanticscholar   +1 more source

Microvasculature-on-a-chip for the long-term study of endothelial barrier dysfunction and microvascular obstruction in disease

Nature Biomedical Engineering, 2018
Alterations in the mechanical properties of erythrocytes occurring in inflammatory and haematological disorders such as sickle-cell disease (SCD) and malaria often lead to increased endothelial permeability, haemolysis and microvascular obstruction ...
Y. Qiu, Byungwook Ahn, Y. Sakurai, Caroline E Hansen, Reginald Tran, P. Mimche, R. Mannino, Jordan C. Ciciliano, T. Lamb, C. Joiner, S. Ofori-Acquah, W. Lam   +11 more
semanticscholar   +1 more source

Tumour associated vasculature-on-a-chip for the evaluation of microbubble-mediated delivery of targeted liposomes

Lab on a Chip, 2023
The vascular system is the primary route for the delivery of therapeutic drugs throughout the body and is an important barrier at the region of disease interest, such as a solid tumour.
Matthew D. Bourn, Safoura Zahed Mohajerani, G. Mavria, N. Ingram, P. Coletta, S. Evans, S. Peyman   +6 more
semanticscholar   +1 more source

Self-assembled cellulose nanofiber-carbon nanotube nanocomposite films with anisotropic conductivity [PDF]

, 2021
In this study, a nanocellulose-based material showing anisotopic conductivity is introduced. The material has up to 1000 times higher conductivity along the dry-line boundary direction than along the radial direction.
Björkqvist, Tomas, Efimov, Alexander, Hannula, Markus, Honkanen, Mari, Kallio, Pasi, Lahtinen, Panu, Mäki, Antti-Juhana, Siljander, Sanna, Skogberg, Anne, Tuukkanen, Sampo   +9 more
core   +2 more sources

Organoid-on-a-chip model of human ARPKD reveals mechanosensing pathomechanisms for drug discovery

Science Advances, 2022
Organoids serve as a novel tool for disease modeling in three-dimensional multicellular contexts. Static organoids, however, lack the requisite biophysical microenvironment such as fluid flow, limiting their ability to faithfully recapitulate disease ...
Ken Hiratsuka, Tomoya Miyoshi, Katharina T. Kroll, Navin R Gupta, M. T. Valerius, Thomas C. Ferrante, M. Yamashita, J. Lewis, Ryuji Morizane   +8 more
semanticscholar   +1 more source

Precision oncology using ex vivo technology: a step towards individualised cancer care? [PDF]

, 2022
Despite advances in cancer genomics and the increased use of genomic medicine, metastatic cancer is still mostly an incurable and fatal disease. With diminishing returns from traditional drug discovery strategies, and high clinical failure rates, more ...
Allen, R., Collis, S.J., Conroy, S., Danson, S.J., Gagg, H., Helleday, T., Hullock, K., Pennington, C.E.W., Rantala, J., Rominiyi, O., Wells, G., Williams, S.T.   +11 more
core   +2 more sources

Microfluidic preparation of optical sensors for biomedical applications

Smart Medicine, 2023
Optical biosensors are platforms that translate biological information into detectable optical signals, and have extensive applications in various fields due to their characteristics of high sensitivity, high specificity, dynamic sensing, etc.
Qiao Wang, Chong Wang, Xinyuan Yang, Jiali Wang, Zhuohao Zhang, Luoran Shang   +5 more
doaj   +1 more source