Results 161 to 170 of about 966,959 (266)

Editorial: Unraveling enzyme-substrate dynamics in protein acylation and disease implications

Frontiers in Molecular Biosciences
Shuyuan Cheng, Shuyuan Cheng, Shuyuan Cheng, Tong Liu, Jing Xing, Guoliang Zhang, Lin Zhang, Lin Zhang, Lin Zhang, Wei Zhao, Wei Zhao, Wei Zhao   +11 more
doaj   +1 more source

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Novel composite inflammatory markers' role in stroke prognosis is understudied, and the best predictor is unclear, requiring further exploration. Objectives This study aimed to systematically evaluate the associations of 6 novel composite inflammatory markers on stroke prognosis.
Bing Wu, Jie‐Jie Li, Jing Jing, Jin‐Xi Lin, Xia Meng, Yong Jiang, Yong‐Jun Wang, Hong‐Qiu Gu   +7 more
wiley   +1 more source

Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers. [PDF]

Alzheimers Res Ther
Boscheck H, Luft M, Mauer R, Senguel S, D'elia Y, Dechent P, Fliessbach K, Glanz W, Hetzer S, Janowitz D, Kilimann I, Kleineidam L, Kronmüller M, Lüsebrink F, Preis L, Rauchmann B, Rostamzadeh A, Schott BH, Sodenkamp S, Spruth E, Stoecklein S, Yakupov R, Ziegler G, Brosseron F, Buerger K, Hellmann-Regen J, Laske C, Perneczky R, Peters O, Priller J, Ramirez A, Schneider A, Spottke A, Teipel S, Wiltfang J, Jessen F, Düzel E, Röske S, Wagner M, Glöckner F, Marchant NL, Klimecki O, Wirth M, DELCODE study group.   +43 more
europepmc   +1 more source

Global Rather Than Vertical‐Selective Saccadic Abnormalities in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To test whether vertical saccades are preferentially affected in Progressive Supranuclear Palsy (PSP). Methods PSP patients (n = 24) were compared to age‐matched controls (n = 94) and two degenerative groups (Alzheimer's disease, n = 20; Lewy body disease, n = 50).
Duy Duan Nguyen, Mark Paine, Soohyun Lee, Amir Fazlollahi, Baibin (Ben) Wang, John D. O'Sullivan, Peter J. Nestor   +6 more
wiley   +1 more source

Exploring the interplay between frailty, Alzheimer's disease biomarkers, and cognitive functioning in patients with mild cognitive impairment: A cross-sectional study. [PDF]

J Alzheimers Dis
Pintus M, Valletta M, Sacchi L, Carandini T, Ghezzi L, Pietroboni A, Fenoglio C, Serpente M, Arcaro M, Bruno G, Galimberti D, Canevelli M, Arighi A.   +12 more
europepmc   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Midlife sleep characteristics and Alzheimer's disease biomarkers 20 years later. [PDF]

Alzheimers Dement
Cavaillès C, Carnethon MR, Knutson KL, Thomas SJ, Yaffe K.   +4 more
europepmc   +1 more source