Results 91 to 100 of about 1,875,199 (316)

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

Translational Psychiatry, 2021
Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and ...
Xiaoyan Li, Xi Su, Jiewei Liu, Huijuan Li, Ming Li, the 23andMe Research Team, Wenqiang Li, Xiong-Jian Luo   +7 more
doaj   +1 more source

A One Health Approach to Hypertrophic Cardiomyopathy. [PDF]

, 2017
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disease in humans and results in significant morbidity and mortality. Research over the past 25 years has contributed enormous insight into this inherited disease particularly in the ...
Stern, Joshua A, Ueda, Yu
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration

Signal Transduction and Targeted Therapy, 2021
SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the blood–brain barrier (BBB).
Ling Zhang, Li Zhou, Linlin Bao, Jiangning Liu, Hua Zhu, Qi Lv, Ruixue Liu, Wei Chen, Wei Tong, Qiang Wei, Yanfeng Xu, Wei Deng, Hong Gao, Jing Xue, Zhiqi Song, Pin Yu, Yunlin Han, Yu Zhang, Xiuping Sun, Xuan Yu, Chuan Qin   +20 more
doaj   +1 more source

A Zebrafish Model of Mycobacterium leprae Granulomatous Infection. [PDF]

, 2017
Understanding the pathogenesis of leprosy granulomas has been hindered by a paucity of tractable experimental animal models. Mycobacterium leprae, which causes leprosy, grows optimally at approximately 30°C, so we sought to model granulomatous disease in
Cameron, James, Madigan, Cressida A, Ramakrishnan, Lalita   +2 more
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Animal models for arthritis: innovative tools for prevention and treatment [PDF]

, 2011
The development of novel treatments for rheumatoid arthritis (RA) requires the interplay between clinical observations and studies in animal models. Given the complex molecular pathogenesis and highly heterogeneous clinical picture of RA, there is an ...
Apparailly, F, Baumans, V, Desaintes, C, Di Santo, J, Distler, J, Garside, P, Gay, S, Hart, B, Hegen, M, Holmdahl, R, Huizinga, T W J, Jüngel, A, Klareskog, L, Kollias, G, McInnes, I, Papadaki, P, Ragoussis, I, Schett, G, Tak, P P, Toes, R, van den Berg, W B, Vervoordeldonk, M J, Wurst, W   +22 more
core   +3 more sources

Animal Models for Human Disease

, 2014
This chapter introduces some types of animal models which are used for better understanding the disease mechanisms and its treatment. These experimental models fall into two categories: spontaneous models and induced models. Among the diseases, rheumatoid arthritis (RA) as an autoimmune disease was considered.
Reza Khorramizadeh, M., Saadat, Farshid
openaire   +1 more source

Animal models of psychiatric disease

Current Opinion in Genetics & Development, 2008
Animal models of psychiatric diseases are useful tools for screening new drugs and for investigating the mechanisms of those disorders. Despite the difficulties inherent in modelling human psychiatric phenotypes in animals, there has been recent success identifying mutations in mice that give rise to some of the characteristic features of anxiety ...
Flint, J, Shifman, S
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source