Results 161 to 170 of about 1,899,644 (265)

Path dependency and the rescuing of the biomedical research enterprise. [PDF]

Front Med Technol
Nahle Z.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Advances and Applications of Organ-on-a-Chip and Tissue-on-a-Chip Technology. [PDF]

Bioengineering (Basel)
Moore M, Sriram S, Ku J, Li Y.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Bioengineered Cellular and Acellular Therapies for Ischemic Heart Disease in Clinically Relevant Models. [PDF]

Bioengineering (Basel)
Muir KC, Zheng C, Yalamanchili K, Reddy R, Joseph A, Hamze J, Harris DD, Sellke FW.   +7 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Theoretical Discussion of Applicability and a Practical Example of Using Statistical Second-Generation Techniques to Analyze Causal Relationships in Animal Experiments. [PDF]

Animals (Basel)
Katrin B.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Systematic Review: Exploring Inter-Species Variability in Diabetes Mellitus for Translational Medicine. [PDF]

Life (Basel)
Hrițcu LD, Boghian V, Pavel G, Hrițcu TD, Nechifor F, Spataru A, Cherșunaru AA, Munteanu A, Ciocoiu M, Spataru MC.   +9 more
europepmc   +1 more source

Animal models and Lyme disease [PDF]

Clinical Microbiology and Infection, 1995
openaire   +2 more sources