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Animal models of Parkinson's disease
BioEssays, 2002AbstractAnimal models are important tools in experimental medical science to better understand pathogenesis of human diseases. Once developed, these models can be exploited to test therapeutic approaches for treating functional disturbances observed in the disease of interest. On the basis of experimental and clinical findings, Parkinson's disease (PD)
Ranjita, Betarbet +2 more
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Animal Models for Human Diseases
Perspectives in Biology and Medicine, 1982The use of animal models for the study of human disease is for the most part a recent development. This discussion of the use of animal models for human diseases directs attention to the sterile period early advances some personal experiences the human as the model biological oddities among common laboratory animals malignancies in laboratory animals ...
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Animal Models of Nonthyroidal Disease*
Endocrine Reviews, 1985Rats bearing transplantable Walker 256 carcinoma provide an opportunity to assess thyroid function and activity during an interval of time when the tumor has not affected growth rate. Rats with tumor have decreased serum T4 and T3 concentration and decreased serum FT4 and FT3 as well.
J M, Tibaldi, M I, Surks
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Animal Models of Cardiovascular Disease
Revista Española de Cardiología (English Edition), 2009The use of animal models to study cardiovascular disease has made a substantial contribution to increasing our understanding of disease pathogenesis, has led to the development of diagnostic techniques, and has made it possible to verify the effectiveness of different preventative and therapeutic approaches, whether pharmacological or interventional ...
Francisco J, Chorro +2 more
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Animal Models for Meningococcal Disease
2003There are many in vitro systems for the study of meningococcal pathogenesis, but it is only in animal models of infection that the interactions of the bacteria with whole tissues and the humoral and cellular immune systems can be assessed. Animal-infection models are also of great importance for the assessment of the protective efficacy of existing and
A R, Gorringe +3 more
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Animal Models of Retinal Disease
2011Diseases of the retina are the leading causes of blindness in the industrialized world. The recognition that animals develop retinal diseases with similar traits to humans has led to not only a dramatic improvement in our understanding of the pathogenesis of retinal disease but also provided a means for testing possible treatment regimes and successful
Erica L, Fletcher +5 more
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New animal models of Parkinson's disease
Movement Disorders, 2011AbstractBackground:Parkinson's disease is a progressive neurodegenerative disorder mainly characterized by the loss of dopaminergic neurons from the substantia nigra pars compacta and the presence, in the affected brain regions, of protein inclusions named Lewy Bodies.
Dehay, Benjamin, Bezard, Erwan
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Animal Models of Menkes Disease
1999There are three recognized X-linked copper deficiency disorders in humans: classical Menkes disease (MD), mild Menkes disease and occipital horn syndrome (OHS, also known as X-linked cutis laxa). Since the features of these diseases are so distinct, it was not clear until recently whether the phenotypes were due to mutations in the same gene, or ...
J F, Mercer +4 more
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Animal Models for Mitochondrial Disease
2003Mutations in mitochondrial genes encoded by both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA have been implicated in a wide range of degenerative diseases. MtDNA base substitution and rearrangement mutations can cause myopathy, cardiomyopathy, ophthalmological defects, growth retardation, movement disorders, dementias, and diabetes.
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