Results 81 to 90 of about 1,905,801 (316)

Western Diet-Fed, Aortic-Banded Ossabaw Swine: A Preclinical Model of Cardio-Metabolic Heart Failure. [PDF]

, 2019
The development of new treatments for heart failure lack animal models that encompass the increasingly heterogeneous disease profile of this patient population.
Alex, Linda, Baines, Christopher P, Domeier, Timothy L, Edwards, Jenna C, Emter, Craig A, Ferreira-Nichols, Stephanie C, Ford, David A, Gao, Chen, Ivey, Jan R, Jones, John L, Jurrissen, Thomas J, Klutho, Paula J, Krenz, Maike, McDonald, Kerry S, Olver, T Dylan, Padilla, Jaume, Rau, Christoph, Rector, R Scott, Solaro, R John, Thorne, Pamela K, Veteto, Adam B, Wang, Yibin, Warren, Chad M   +22 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

HIV vaccine candidate ΔV1gp120 formulated in ALFQA adjuvant augments mucosal immunity in female macaques

Nature Communications
Simian or Human immunodeficiency virus (SIV or HIV) vaccines based on V1-deleted envelope virus-like particles, delivered by the DNA/ALVAC platforms, followed by the ΔV1gp120 boost formulated in Alum, protect 50% and 80% of macaques from mucosal ...
Massimiliano Bissa, Mohammad Arif Rahman, Luca Schifanella, Katherine C. Goldfarbmuren, Isabela Silva de Castro, Emmanuel K. Woode, Anna Gutowska, Melvin N. Doster, Sophia Brown, Sarkis Sarkis, Neil R. Kanchetty, Cynthia A. Pise-Masison, Robyn Washington-Parks, Katherine McKinnon, Shraddha Basu, Jiae Kim, Ryan Alving, Dominic Paquin-Proulx, Kombo F. N’guessan, Xiaoying Shen, David C. Montefiori, Timothy Cardozo, Gary R. Matyas, Mangala Rao, Genoveffa Franchini   +24 more
doaj   +1 more source

CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis

Nature Communications, 2020
Circular RNAs are expressed in the brain and show age-dependent expression patterns. Here the authors show the circGRIA1 is expressed in an age-dependent manner in the male macaque brain and serves a functional role in synaptic plasticity.
Kaiyu Xu, Ying Zhang, Wandi Xiong, Zhongyu Zhang, Zhengbo Wang, Longbao Lv, Chao Liu, Zhengfei Hu, Yong-Tang Zheng, Lin Lu, Xin-Tian Hu, Jiali Li   +11 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Poor second ovarian stimulation in cynomolgus monkeys (Macaca fascicularis) is associated with the production of antibodies against human follicle-stimulating hormone

The Journal of Reproduction and Development, 2019
Cynomolgus monkeys (Macaca fascicularis) are a valuable model organism for human disease modeling because human physiology and pathology are closer to those of cynomolgus monkeys than rodents.
Yasunari SEITA, Chizuru IWATANI, Hideaki TSUCHIYA, Shinichiro NAKAMURA, Fuminori KIMURA, Takashi MURAKAMI, Masatsugu EMA   +6 more
doaj   +1 more source

Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression

Advanced Science, 2022
Genome‐wide association studies have identified 3p21.1 as a robust risk locus for schizophrenia. However, the underlying molecular mechanisms remain elusive.
Yifan Li, Changguo Ma, Shiwu Li, Junyang Wang, Wenqiang Li, Yongfeng Yang, Xiaoyan Li, Jiewei Liu, Jinfeng Yang, Yixing Liu, Kaiqin Li, Jiao Li, Di Huang, Rui Chen, Luxian Lv, Xiao Xiao, Ming Li, Xiong‐Jian Luo   +17 more
doaj   +1 more source

Neutrophils in animal models of autoimmune disease [PDF]

, 2016
Neutrophils have traditionally been thought to play only a peripheral role in the genesis of many autoimmune and inflammatory diseases. However, recent studies in a variety of animal models suggest that these cells are central to the initiation and ...
Abram, Ajuebor, Albanesi, Alves, Amaral, Askenasy, Attila Mócsai, Aube, Baik, Barnado, Bento, Binstadt, Braswell, Brinkmann, Buanne, Campbell, Campbell, Carlson, Carneiro-Sampaio, Chan, Chen, Chen, Chen, Chiriac, Christensen, Clifford A. Lowell, Coit, Coquery, Cronstein, Croxford, Cumpelik, Diana, Diana, Ditzel, Dwivedi, Ehrenstein, Elliott, Eyles, Forster, Fournier, Futosi, Gaipl, Garcia, Goldberg, Grayson, Guerreiro-Cacais, Guiducci, Gupta, Hattar, Heimbach, Helms, Henry, Heymann, Hickman, Holden, Huang, Kahlenberg, Kallenberg, Kaplan, Katayama, Kelkka, Kessenbrock, Kim, Kishida, Knight, Knight, Knight, Kovacs, Kuhl, Lamagna, Lande, Li, Lin, Lindwall, Liu, Lood, Maalouf, Maicas, Mancardi, Marciano, Marrakchi, Martinon, Mayadas, McColl, McGonagle, McGonagle, Merrill, Metzler, Metzler, Miller, Milora, Mocsai, Mocsai, Moline-Velazquez, Nemeth, Nesterovitch, O'Shea, Odobasic, Odobasic, Okumura, Ooi, Oswald, Palanichamy, Palmen, Patel, Pfister, Pieterse, Pietronigro, Pietrosimone, Rodrigues-Sousa, Rohrbach, Rumble, Ryckman, Sadik, Samavedam, Sangaletti, Scapini, Scapini, Schauer, Schmidt, Schon, Schon, Schreiber, Schreiber, Schreiber, Shao, Smith, Smith, So, Spengler, Steiger, Steinbach, Sumida, Summers, Tamás Németh, Terkeltaub, Tortola, Ueyama, van der Fits, Vandal, Volmering, Wallace, Walter, Willis, Wipke, Wise, Xiao, Yu, Zehntner, Zenaro, Zhang, Zhang   +151 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Transcriptome-wide association study identifies new susceptibility genes and pathways for depression

Translational Psychiatry, 2021
Depression is the most prevalent mental disorder with substantial morbidity and mortality. Although genome-wide association studies (GWASs) have identified multiple risk variants for depression, due to the complicated gene regulatory mechanisms and ...
Xiaoyan Li, Xi Su, Jiewei Liu, Huijuan Li, Ming Li, the 23andMe Research Team, Wenqiang Li, Xiong-Jian Luo   +7 more
doaj   +1 more source