Results 91 to 100 of about 51,218 (319)

Tendinopathy—from basic science to treatment [PDF]

, 2008
Chronic tendon pathology (tendinopathy), although common, is difficult to treat. Tendons possess a highly organized fibrillar matrix, consisting of type I collagen and various 'minor' collagens, proteoglycans and glycoproteins.
A McCormick, AH Drummond, AJ Banes, AN Bamji, AN Corps, AN Corps, AN Corps, AP D'Vaz, B Pasternak, BL Woodley, BM Clancy, CA Speed, D Bjur, EM Badley, G Puddu, G Riley, GAC Murrell, GC Jones, GC Jones, GP Riley, GP Riley, Graham Riley, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Alfredson, H Langberg, H Langberg, H Langberg, H Nagase, HA Awad, J Archambault, JA Paoloni, JA Paoloni, JA Paoloni, JD Rompe, JE Carpenter, JL Cook, JM Archambault, L Józsa, L Ohberg, LC Almekinders, LJ McCawley, M Aström, M Benjamin, M Gotoh, M Gotoh, M Lavagnino, M Lavagnino, MD Chard, ME Jones, MH Khan, N Mafi, P Burssens, P Kannus, R Salingcarnboriboon, RA Bank, RF Ker, RK Smith, SA Fenwick, SC Fu, SG Rees, SP Arnoczky, T Pufe, T Pufe, T Samiric, TG Gerich, TW Ehlers, UM Wewer   +69 more
core   +1 more source

Isolation of bothrasperin, a disintegrin with potent platelet aggregation inhibitory activity, from the venom of the snake Bothrops asper

Revista de Biología Tropical, 2003
The venom of Bothrops asper induces severe coagulation disturbances in accidentally envenomed humans. However, only few studies have been conducted to identify components that interact with the hemostatic system in this venom.
Adrián Pinto, Yamileth Angulo, Rafael Jiménez, Bruno Lomonte   +3 more
doaj  

Evolutionary divergence and functions of the ADAM and ADAMTS gene families

Human Genomics, 2009
The 'A-disintegrin and metalloproteinase' (ADAM) and 'A-disintegrin and metalloproteinase with thrombospondin motifs' (ADAMTS) genes make up two similar, yet distinct, gene families.
Brocker Chad N, Vasiliou Vasilis, Nebert Daniel W   +2 more
doaj   +1 more source

Extracellular Matrix Enzymes and Immune Cell Biology

Frontiers in Molecular Biosciences, 2021
Remodelling of the extracellular matrix (ECM) by ECM metalloproteinases is increasingly being associated with regulation of immune cell function. ECM metalloproteinases, including Matrix Metalloproteinases (MMPs), A Disintegrin and Metalloproteinases ...
Meagan McMahon, Siying Ye, Jess Pedrina, Daniel Dlugolenski, John Stambas   +4 more
doaj   +1 more source

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor, Beric Muller, Lesetja R. Motadi, Lizelle A. Piater   +3 more
wiley   +1 more source

Chronic tendon pathology: molecular basis and therapeutic implications [PDF]

, 2005
Tendons are frequently affected by chronic pain or rupture. Many causative factors have been implicated in the pathology, which until relatively recently was under-researched and poorly understood.
Riley, GP
core   +1 more source

Reduced JAG1 Expression Through miR‐200 Overexpression or Crispr‐Cas Mediated Knockout Impairs TNBC Growth and Metastasis

Molecular Carcinogenesis, EarlyView.
ABSTRACT Studies from our lab demonstrated that increasing miR‐200 expression in human triple negative breast cancer (TNBC) reduced tumor growth and metastasis In Vivo. In this study, we found that overexpression of miR‐200s in TNBC cells significantly reduced the expression of JAG1.
Megan Vaz, Katrina L. Watson, Roger A. Moorehead   +2 more
wiley   +1 more source

NKG2D and its ligands: one for all, all for one [PDF]

, 2018
The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Cerboni, Cristina, Cippitelli, Marco, Fionda, Cinzia, Molfetta, Rosa, Paolini, Rossella, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +7 more
core   +2 more sources

Effect of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and smoking in COPD

Egyptian Journal of Chest Disease and Tuberculosis, 2012
Background: COPD is characterized by air flow limitation that is not fully reversed and associated with an influx of neutrophils, macrophages and CD8 T lymphocytes in the airways.
Ayman H. Abd El-Zaher, Hala Nagy, Gihan Farouk, Ahmed Sh. Mohamed, Naglaa F. Ghoname   +4 more
doaj   +1 more source

TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions

Journal of Biological Chemistry, 2015
A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane metalloprotease that cleaves the extracellular regions from its transmembrane substrates.
Peter J. Noy, Jing Yang, J. Reyat, A. Matthews, Alice E. Charlton, Joanna Furmston, D. Rogers, G. Rainger, M. Tomlinson   +8 more
semanticscholar   +1 more source