Results 81 to 90 of about 62,920 (233)
Viper Venom Disintegrins and Related Molecules
Experimental Biology and Medicine, 1998 The term "disintegrin" was first used in 1990 to describe a group of viper venom-derived, nonenzymatic small proteins that shared numerous structural and functional properties. These proteins, which have been found in a great number of viper species studied since that time possess both a remarkable sequence homology and an equally notable variability ...
M A, McLane +4 more
openaire +2 more sources
The role of matrix- and disintegrin-metalloproteinases in neurodegenerative diseases [PDF]
, 2002 Schlomann U. The role of matrix- and disintegrin-metalloproteinases in neurodegenerative diseases.
Schlomann, Uwe
core
Metalloproteinases and Their Inhibitors: Potential for the Development of New Therapeutics
Cells, 2020 The metalloproteinase (MP) family of zinc-dependent proteases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs) plays a crucial role in ...
Maryam Raeeszadeh-Sarmazdeh +2 more
doaj +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family [PDF]
Genome Biology, 2015 AbstractThe ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse roles in tissue morphogenesis and patho-physiological remodeling, in inflammation and in vascular biology.
Kelwick, Richard +3 more
openaire +4 more sources
Cloning, purification and characterisation of human and mouse ADAM 8 sheddase activity [PDF]
, 2006 Al-Riyami H. Cloning, purification and characterisation of human and mouse ADAM 8 sheddase activity.
Al-Riyami, Hamed
core +1 more source
Aberrant Expression of Disintegrin-Metalloprotease Proteins in the Formation and Progression of Uterine Cervical Cancer [PDF]
, 2011 <i>Objective:</i> Dysregulated expression of disintegrin-metalloprotease proteins [a disintegrin and metalloproteases (ADAMs) and ADAMs with thrombospondin motif (ADAMTSs)] has been reported in many types of cancers and is believed to play an
Seiji Mori +7 more
core +1 more source
Artery Research, 2009 An age-related increase in systolic blood pressure and similarities in the consequences of hypertension and aging on arterial structure/mechanics have been reported, particularly in larger arteries.
K.R. Parmar +2 more
doaj +1 more source
VIEW, EarlyView.Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley +1 more source
Intracellular Maturation of the Mouse Metalloprotease Disintegrin MDC15 [PDF]
Journal of Biological Chemistry, 1998 Metalloprotease disintegrins are a family of membrane-anchored glycoproteins that play a role in fertilization, myoblast fusion, neuronal development, and cleavage of the membrane-anchored cytokine tumor necrosis factor-alpha. Here, we report the cloning and cDNA sequencing of the mouse metalloprotease disintegrin MDC15 and an analysis of its ...
L, Lum, M S, Reid, C P, Blobel
openaire +2 more sources