Results 81 to 90 of about 65,779 (239)

Irradiation‐Induced CD62L Shedding in Human Plasmacytoid Dendritic Cells Depends on ADAM17 and p38 MAPK

Immunology, EarlyView.
Human plasmacytoid dendritic cell‐based vaccines efficiently migrate from blood to lymph nodes and prime naive T cells in humanised mice. Irradiation‐induced CD62L shedding, mediated by p38 MAP kinase and ADAM17, is involved in the regulation of PDC migration to secondary lymphoid organs in this model.
Estelle Leplus, Jamila Kacher, Dalil Hannani, Guillaume Vayssiere, Jean‐Paul Molens, Karine Laulanier, Dan Georgess, Véronique Josserand, Philippe Saas, Séverine Planel, Laurence Chaperot, Joel Plumas   +11 more
wiley   +1 more source

Improvements in Endotoxemic Syndromes Using a Disintegrin, Rhodostomin, through Integrin Alpha V Beta 3-Dependent Pathway

, 2012
Background and objectives: Septic shock is a major cause of morbidity and mortality in intensive care units, but there is still no effective therapy for the patients.
許竣傑;莊偉哲;張倩馨;曾昱綸;彭惠琴;黃德富, HSU, CHUN-CHIEH;CHUANG, WOEI-JER;CHANG, CHIEN-HSIN;TSENG, YU-LUN;PENG, HUI-CHIN;HUANG, TUR-FU   +1 more
core  

Lipotoxicity Amplifies IL‐6 Trans‐Signaling in Sinusoidal Endothelial Cells to Promote Endotheliopathy and Liver Injury

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects approximately 25% of the global population and is a major health concern. Liver sinusoidal endothelial cells (LSECs) undergo morphological and functional alterations during MASLD progression, resulting in endotheliopathy characterized by pro ...
Yasuhiko Ueda, Nao Kawaguchi, Yosuke Inomata, Jun Arima, Mitsuaki Ishida, Yuko Ito, Sang‐Woong Lee, Kohei Taniguchi   +7 more
wiley   +1 more source

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases

Mediators of Inflammation, 2017
Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies.
D. Dreymueller, K. Theodorou, M. Donners, A. Ludwig   +3 more
doaj   +1 more source

Effect of a disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and smoking in COPD

Egyptian Journal of Chest Disease and Tuberculosis, 2012
Background: COPD is characterized by air flow limitation that is not fully reversed and associated with an influx of neutrophils, macrophages and CD8 T lymphocytes in the airways.
Ayman H. Abd El-Zaher, Hala Nagy, Gihan Farouk, Ahmed Sh. Mohamed, Naglaa F. Ghoname   +4 more
doaj   +1 more source

ADAMDEC1 and FGF2/FGFR1 signaling constitute a positive feedback loop to maintain GBM cancer stem cells

Molecular & Cellular Oncology, 2020
Identification of targetable mechanisms that maintain glioblastoma cancer stem cells (CSCs) remain a priority. Our study reveals a new mechanism by which a disintegrin and metalloproteinase domain-like protein decysin 1 promotes CSC maintenance through ...
Ana Jimenez-Pascual, Justin D. Lathia, Florian A. Siebzehnrubl   +2 more
doaj   +1 more source

Thirty Years of Autologous Platelet Concentrates: From Platelet‐Rich Plasma to Platelet‐Rich Fibrin

Journal of Periodontal Research, EarlyView.
This review highlights the 30 years of evolution of APCs, with a focus on their clinical applications and recent technological advancements. ABSTRACT Nearly three decades have now passed since autologous platelet concentrates (APCs) were introduced into clinical practice.
Richard J. Miron, Nathan E. Estrin, Paras Ahmad, Nima Farshidfar, Masako Fujioka‐Kobayashi, Yufeng Zhang, Mario Romandini, Reinhard Gruber   +7 more
wiley   +1 more source

Cloning, purification and characterisation of human and mouse ADAM 8 sheddase activity [PDF]

, 2006
Al-Riyami H. Cloning, purification and characterisation of human and mouse ADAM 8 sheddase activity.
Al-Riyami, Hamed
core  

Isolation and in silico characterization of a leishmanicidal disintegrin from cerastes cerastes venom

, 2018
International audienceBackground: Leishmaniasis represents a serious public health problem in Algeria. The parasite, in the promastigote form, upon transfer by the infected vector to the vertebrate host, invades mononuclear macrophages and causes ...
Allane, Dihia, Oussedik-Oumehdi, Habiba, Harrat, Zoubir, Michelland, Sylvie, Seve, Michel, Laraba-Djebari, Fatima   +5 more
core   +1 more source

Saliva Liquid Biopsy for Detection of Oral and Systemic Diseases

Journal of Periodontal Research, EarlyView.
This Review summarizes and discusses the biological foundations and major classes of salivary biomarkers, outlines collection methods and analytical protocols for saliva‐based liquid biopsy, and technological convergences driven by multi‐omics approaches, artificial intelligence, and point‐of‐care devices in the application of oral and systemic ...
Irene Choi, Aaron Zander, Bradley Chan, Leila Syedmoradi, Dev Trivedi, Karolina Elżbieta Kaczor‐Urbanowicz, Fang Wei, Neeti Swarup, Trinity Chan, Mario Romandini, David T. W. Wong   +10 more
wiley   +1 more source