Results 61 to 70 of about 62,920 (233)

Diversity of metalloproteinases in Bothrops neuwiedi snake venom transcripts: evidences for recombination between different classes of SVMPs

BMC Genetics, 2011
Background Snake venom metalloproteinases (SVMPs) are widely distributed in snake venoms and are versatile toxins, targeting many important elements involved in hemostasis, such as basement membrane proteins, clotting proteins, platelets, endothelial and
Valente Richard H, Clissa Patrícia B, Portes-Junior José, Grego Kathleen F, Caporrino Maria, Furlan Maria, Moura-da-Silva Ana M, Magalhães Geraldo S   +7 more
doaj   +1 more source

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, EarlyView.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Dilated cardiomyopathy (DCM) is a common cause of heart failure in adult and pediatric patients, but the underlying mechanism may vary in adults and children, with few studies conducted to date.
Sayantan Jana, Hao Zhang, Gary D. Lopaschuk, Darren H. Freed, Consolato Sergi, Paul F. Kantor, Gavin Y. Oudit, Zamaneh Kassiri   +7 more
doaj   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Importance of the Porcine ADAM3 Disintegrin Domain in Sperm-Egg Interaction [PDF]

, 2009
In the mouse, ADAM3, a well-characterized testis-specific protein of the A disintegrin and metalloprotease (ADAM) family, has a crucial role in fertilization by mediating sperm binding to the egg zona pellucida.
Ji-Su KIM, Myeong-Su KIM, D B Koo, Jae-Woong LEE, Dong Chul BAEK, Han-Seok KANG, Sang Rae Lee, Ekyune KIM, Sang-Rae LEE, J W Lee, Z Y Ryoo, Chan-Shick KIM, Sang-Hyun KIM, H S Kang, Kyu Tae Chang, Ki-Eun PARK, Kyu-Tae CHANG, C S Kim, Deog-Bon KOO, K E Park, Zae-Young RYOO, Ji Su Kim, Myeong Su Kim   +22 more
core   +1 more source

ADAM and ADAMTS disintegrin and metalloproteinases as major factors and molecular targets in vascular malfunction and disease [PDF]

, 2022
A Disintegrin and Metalloproteinase (ADAM) and A Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) are two closely related families of proteolytic enzymes.
Raouf A. Khalil, Khalil, Raouf A., HaiFeng Yang, Yang, HaiFeng   +3 more
core   +1 more source

Isolation of bothrasperin, a disintegrin with potent platelet aggregation inhibitory activity, from the venom of the snake Bothrops asper

Revista de Biología Tropical, 2003
The venom of Bothrops asper induces severe coagulation disturbances in accidentally envenomed humans. However, only few studies have been conducted to identify components that interact with the hemostatic system in this venom.
Adrián Pinto, Yamileth Angulo, Rafael Jiménez, Bruno Lomonte   +3 more
doaj  

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

Regulatory effect of disintegrin on adipogenesis [PDF]

, 2007
脂肪新生(adipogenesis)在肥胖的發展上扮演了很重要的角色，其過程包括前驅脂肪細胞的移動、附著、增生、生存及分化為成熟的脂肪細胞，而這些機能都和細胞上integrin的調控有關，於是我們利用由蛇毒中所純化出的disintegrin－trigramin、triflavin、rhodostomin－來探討它們對脂肪新生的影響。由實驗結果發現，disintegrin會造成初級前驅脂肪細胞及3T3-L1細胞株的脫落，並對focal adhesion產生影響，包括p-FAK ...
林玉婷, Lin, Yu-Ting
core  

Pharmacological aspects of Vipera xantina palestinae venom [PDF]

, 2011
In Israel, Vipera xantina palestinae (V.x.p.) is the most common venomous snake, accounting for several hundred cases of envenomation in humans and domestic animals every year, with a mortality rate of 0.5 to 2%.
Katzhendler, Jeoshua, Franziska T. Arlinghaus, Jeoshua Katzhendler, Cezary Marcinkiewicz, Philip Lazarovici, Arlinghaus, Franziska T., Johannes A. Eble, Lazarovici, Philip, Momic, Tatjana, Eble, Johannes A., Hadar Arien-Zakay, Marcinkiewicz, Cezary, Tatjana Momic, Arien-Zakay, Hadar, Arlinghaus, Franziska Therese   +14 more
core   +1 more source