Results 41 to 50 of about 65,779 (239)

Alternagin-C (ALT-C), a Disintegrin-Like Cys-Rich Protein Isolated from the Venom of the Snake Rhinocerophis alternatus, Stimulates Angiogenesis and Antioxidant Defenses in the Liver of Freshwater Fish, Hoplias malabaricus

Toxins, 2017
Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis.
Diana Amaral Monteiro, Heloisa Sobreiro Selistre-de-Araújo, Driele Tavares, Marisa Narciso Fernandes, Ana Lúcia Kalinin, Francisco Tadeu Rantin   +5 more
doaj   +1 more source

A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine–Glycine–Aspartic Acid (RGD)-Containing Molecules

Toxins
Viperid snake venoms are notably abundant in metalloproteinases (proteins) (SVMPs), which are primarily responsible for inducing hemorrhage and disrupting the hemostatic process and tissue integrity in envenomed victims.
Pedro Henrique de Caires Schluga, Debora Larangote, Ana Maria de Melo, Guilherme Kamienski Lobermayer, Daniel Torrejón, Luciana Souza de Oliveira, Valeria Gonçalves Alvarenga, Dan Erick Vivas-Ruiz, Silvio Sanches Veiga, Eladio Flores Sanchez, Luiza Helena Gremski   +10 more
doaj   +1 more source

ALT-C, a disintegrin-like Cys-rich protein from Bothrops alternatus, increases skeletal myoblast viability

Journal of Venomous Animals and Toxins including Tropical Diseases, 2009
ALT-C, an ECD motif (glutamic acid, cysteine, aspartic acid) disintegrin from Bothrops alternatus snake venom, induces α2β1 integrin-mediated signaling and neutrophil chemotaxis.
RA Mesquita-Ferrari, CK de Moraes, KC Micocci, HS Selistre-de-Araújo   +3 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Intracellular activation and processing of human disintegrin and metalloproteinase 19 (hADAM19) [PDF]

, 2003
Kang T. Intracellular activation and processing of human disintegrin and metalloproteinase 19 (hADAM19). Bielefeld (Germany): Bielefeld University; 2003.Adamalysin 19 (a disintegrin and metalloproteinase 19, ADAM19, or meltrin [beta]) is a plasma ...
Kang, Tiebang
core  

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Pharmacological aspects of Vipera xantina palestinae venom [PDF]

, 2011
In Israel, Vipera xantina palestinae (V.x.p.) is the most common venomous snake, accounting for several hundred cases of envenomation in humans and domestic animals every year, with a mortality rate of 0.5 to 2%.
Katzhendler, Jeoshua, Franziska T. Arlinghaus, Jeoshua Katzhendler, Cezary Marcinkiewicz, Philip Lazarovici, Arlinghaus, Franziska T., Johannes A. Eble, Lazarovici, Philip, Momic, Tatjana, Eble, Johannes A., Hadar Arien-Zakay, Marcinkiewicz, Cezary, Tatjana Momic, Arien-Zakay, Hadar, Arlinghaus, Franziska Therese   +14 more
core   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases

Frontiers in Cardiovascular Medicine, 2020
Despite recent advances in treatment strategies, infectious diseases are still under the leading causes of death worldwide. Although the activation of the inflammatory cascade is one prerequisite of defense, persistent and exuberant immune response ...
Ahmad Aljohmani, Daniela Yildiz
doaj   +1 more source

The First Snake Venom KTS/Disintegrins-Integrin Interactions Using Bioinformatics Approaches

Molecules, 2022
Snake venom contains a number of active molecules that have been shown to possess high anti-tumor activities; disintegrins are an excellent example among these.
Oussema Khamessi, Hazem Ben Mabrouk, Selim Kamoun, Chaima Hkimi, Kais Ghedira, Riadh Kharrat   +5 more
doaj   +1 more source