Results 41 to 50 of about 77,378 (253)
Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/gamma-secretase activity [PDF]
, 2009 L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role in the progression of human carcinoma. Overexpression promotes tumour-cell invasion and motility, growth in nude mice and tumour metastasis.
Altevogt, Peter +6 more
core +2 more sources
Acta Chimica Slovenica, 2017 Integrins are plasma membrane proteins, dysfunction frequently result in cancer pathology, so they represent important targets of anti-tumor therapy. Snake venoms are known source of disintegrins (Dis), proteins that specifically bind integrins and thus ...
Zorica Latinović +4 more
doaj +1 more source
Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
eLife, 2023 The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknown.
Elisabeth Jongsma +3 more
doaj +1 more source
Porcine oocyte maturation in vitro : role of cAMP and oocyte-secreted factors: a practical approach [PDF]
, 2016 Polyspermy or the penetration of more than one sperm cell remains a problem during porcine in vitro fertilization (IVF). After in vitro culture of porcine zygotes, only a low percentage of blastocysts develop and their quality is inferior to that of in ...
Appeltant, Ruth +4 more
core +2 more sources
Cell Death and Disease, 2022 Disintegrin-metalloproteinase 15(ADAM15), a member of disintegrin metalloproteinases (ADAMs), plays important roles in various cancer types. However, the underlying ADAM15 functioning in lung cancer is still unclear.
Jieqi Zhou +11 more
doaj +1 more source
Intracellular Processing of Metalloprotease Disintegrin ADAM12 [PDF]
Journal of Biological Chemistry, 2002 ADAM12 has been implicated in cell-cell interactions in myogenesis and cancer, but the structure of the mature form of ADAM12 is not known, and its localization on the cell surface has been questioned. In this report, we show that full-length ADAM12 is N-glycosylated in the endoplasmic reticulum (ER) and proteolytically processed in the trans-Golgi ...
Yi, Cao +3 more
openaire +2 more sources
Toxins, 2017 Alternagin-C (ALT-C) is a disintegrin-like protein isolated from Rhinocerophis alternatus snake venom, which induces endothelial cell proliferation and angiogenesis.
Diana Amaral Monteiro +5 more
doaj +1 more source
Disintegrin targeting of an αvβ3 integrin-over-expressing high-metastatic human osteosarcoma with echistatin inhibits cell proliferation, migration, invasion and adhesion in vitro. [PDF]
, 2016 The in vitro efficacy of the disintegrin echistatin was tested on a high-metastatic variant of 143B human osteosarcoma, 143B-LM4, which over-expresses αvβ3 integrin. Echistatin is an RGD cyclic peptide and an antagonist of αvβ3 integrin.
Bouvet, Michael +7 more
core +4 more sources
Bioinformatics analysis of structure and function of Lebestatine isolated from Macrovipera venom [PDF]
Journal of Advanced Biomedical Sciences, 2017 Background & Objective: Lebestatin is a new member of disintegrin family. This single-chain poly peptide comprises 107 amino acids isolated from Macrovipera venom.
Maryam Rabiee +2 more
doaj
Journal of Venomous Animals and Toxins including Tropical Diseases, 2009 ALT-C, an ECD motif (glutamic acid, cysteine, aspartic acid) disintegrin from Bothrops alternatus snake venom, induces α2β1 integrin-mediated signaling and neutrophil chemotaxis.
RA Mesquita-Ferrari +3 more
doaj +1 more source