Disintegrins from Hematophagous Sources [PDF]
Toxins, 2012 Bloodsucking arthropods are a rich source of salivary molecules (sialogenins) which inhibit platelet aggregation, neutrophil function and angiogenesis. Here we review the literature on salivary disintegrins and their targets. Disintegrins were first discovered in snake venoms, and were instrumental in our understanding of integrin function and also for
Ivo M. B. Francischetti +2 more
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Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering [PDF]
Biochemical Journal, 2003 We report the isolation and amino acid sequences of six novel dimeric disintegrins from the venoms of Vipera lebetina obtusa (VLO), V. berus (VB), V. ammodytes (VA), Echis ocellatus (EO) and Echis multisquamatus (EMS). Disintegrins VLO4, VB7, VA6 and EO4 displayed the RGD motif and inhibited the adhesion of K562 cells, expressing the integrin α5β1 to ...
Calvete, Juan +4 more
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A-Disintegrin and metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells [PDF]
, 2012 It has been proposed that gliomas contain a subpopulation of 'Brain Tumor Stem Cells' (BTSCs), which demonstrate resistance to conventional therapies.
Siney, Elodie J +11 more
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Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8 [PDF]
, 2006 ADAM proteases are type I transmembrane proteins with extracellular metalloprotease domains. As for most ADAM family members, ADAM8 (CD156a, MS2) is involved in ectodomain shedding of membrane proteins and is linked to inflammation and neurodegeneration.
Bartsch, Jörg W. +15 more
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ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview
Toxins, 2016 A disintegrin and metalloproteinase (ADAM) family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors ...
Soichi Takeda
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The Role of Snake Venom Disintegrins in Angiogenesis
Toxins, 2023 Angiogenesis is a critical process in various physiological and pathological conditions, and snake venom disintegrins (SVDs) have been shown to be important regulators of this process. In this review, we explore the dual roles of SVD in angiogenesis, both as antiangiogenic agents by inhibiting integrin binding and interfering with vascular endothelial ...
Patricia Bianca Clissa +3 more
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The disintegrin, trimucrin, suppresses LPS-induced activation of phagocytes primarily through blockade of NF-kappa B and MAPK activation [PDF]
, 2017 In addition to antiplatelet activity, disintegrin, a small-mass RGD-containing polypeptide, has been shown to exert anti-inflammatory effects but the mechanism involved remains unclear.
Hung, Yu-Chun;Hsu, Chun-Chieh;Chung, Ching-Hu;Huang, Tur-Fu +1 more
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A Novel Venom-Derived Peptide for Brachytherapy of Glioblastoma: Preclinical Studies in Mice
Molecules, 2018 We developed a bacterial expression system to produce a recombinant disintegrin, vicrostatin (VCN), whose structure is based on a natural disintegrin isolated from southern copperhead snake venom.
Steve Swenson +5 more
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A Disintegrin and Metalloproteinase Protein 8 (ADAM 8) in Autism Spectrum Disorder: Links to Neuroinflammation [PDF]
, 2023 Laila Al-Ayadhi,1,2 Amani Abualnaja,3 Abdullah AlZarroug,3 Turki Alharbi,3 Abdulrahman M Alhowikan,1,2 Dost M Halepoto,1 Sarah Al-Mazidi4 1Autism Research and Treatment Centre, Faculty of Medicine, King Saud University, Riyadh, 11461, Saudi Arabia ...
Al-Ayadhi L +6 more
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Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells
Toxins, 2016 Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties.
Manel B. Hammouda +8 more
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