Results 31 to 40 of about 62,920 (233)
Integrins, cancer and snake toxins (mini-review)
Journal of Venomous Animals and Toxins including Tropical Diseases, 2005 Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
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Isolation and characterization of an anti-leishmanial disintegrin from Cerastes cerastes venom [PDF]
, 2017 International audienceInvestigating new antimicrobial and antiparasitic components from Viperidae venoms represents an alternative therapeutic strategy. In this study, we report the characterization of a disintegrin isolated from Cerastes cerastes venom,
Allane, Dihia +9 more
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The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM
Toxins, 2015 Melittin, which acts as a membrane-disrupting lytic peptide, is not only cytotoxic to tumors, but also vital to normal cells. Melittin had low toxicity when coupled with target peptides.
Dejun Sun +5 more
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Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans
eLife, 2023 The amyloid beta (Aβ) plaques found in Alzheimer’s disease (AD) patients’ brains contain collagens and are embedded extracellularly. Several collagens have been proposed to influence Aβ aggregate formation, yet their role in clearance is unknown.
Elisabeth Jongsma +3 more
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Intracellular Processing of Metalloprotease Disintegrin ADAM12 [PDF]
Journal of Biological Chemistry, 2002 ADAM12 has been implicated in cell-cell interactions in myogenesis and cancer, but the structure of the mature form of ADAM12 is not known, and its localization on the cell surface has been questioned. In this report, we show that full-length ADAM12 is N-glycosylated in the endoplasmic reticulum (ER) and proteolytically processed in the trans-Golgi ...
Yi, Cao +3 more
openaire +2 more sources
Acta Chimica Slovenica, 2017 Integrins are plasma membrane proteins, dysfunction frequently result in cancer pathology, so they represent important targets of anti-tumor therapy. Snake venoms are known source of disintegrins (Dis), proteins that specifically bind integrins and thus ...
Zorica Latinović +4 more
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Multimeric Disintegrin Protein Polymer Fusions That Target Tumor Vasculature [PDF]
, 2015 Recombinant protein therapeutics have increased in number and frequency since the introduction of human insulin, 25 years ago. Presently, proteins and peptides are commonly used in the clinic.
Lye Lin Lock (1309743) +11 more
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Cell Death and Disease, 2022 Disintegrin-metalloproteinase 15(ADAM15), a member of disintegrin metalloproteinases (ADAMs), plays important roles in various cancer types. However, the underlying ADAM15 functioning in lung cancer is still unclear.
Jieqi Zhou +11 more
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Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]
, 2011 Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory +5 more
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Bioinformatics analysis of structure and function of Lebestatine isolated from Macrovipera venom [PDF]
Journal of Advanced Biomedical Sciences, 2017 Background & Objective: Lebestatin is a new member of disintegrin family. This single-chain poly peptide comprises 107 amino acids isolated from Macrovipera venom.
Maryam Rabiee +2 more
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