Results 31 to 40 of about 77,378 (253)

ADAMTS -1 and -4 are up-regulated following transient middle cerebral artery occlusion in the rat and their expression is modulated by TNF in cultured astrocytes [PDF]

, 2006
ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) enzymes are a recently described group of metalloproteinases. The substrates degraded by ADAMTS-1, -4 and -5 suggests that they play a role in turnover of extracellular matrix in the
A.K. Cross, Abbaszzade, Asher, Bandtlow, Buttini, C.J. Stock, Cardenas, Clark, Clausen, Collins-Racie, D.J. Buttle, Eddleston, G. Haddock, Hashimoto, Inatani, J. Surr, Jiang, Jones, Krekoski, Krupinski, Kuno, Kuno, Kurazono, Legos, M.N. Woodroofe, Medina-Flores, Miguel, Mulcahy, Nedergaard, Novak, Ohtaki, Pangalos, Pekny, Plumb, Porter, R.A.D. Bunning, Rawlings, Rhodes, Rosenberg, Rosenberg, Rothwell, S. Allan, Satoh, Smith, Sobel, Somerville, Tang, Tsuzaki, Vankemmelbeke, Vazquez, Wang, Yamaguchi, Yu   +52 more
core   +1 more source

Hypercoagulability progresses to hypocoagulability during evolution of acetaminophen-induced acute liver injury in pigs [PDF]

, 2017
Increases in prothrombin time (PT) and international normalised ratio (INR) characterise acute liver injury (ALI) and failure (ALF), yet a wide heterogeneity in clotting abnormalities exists.
A Clauss, A Gatt, A Tripodi, A Zambruni, AF Riddell, AO Spiel, B Agarwal, B Agarwal, B Agarwal, DJ Antoine, DJ Antoine, E Gehrie, EA Sankey, FB Mayr, GC Hugenholtz, H Schochl, HJ Tsai, J Vaquero, JG O’Grady, JH Griffin, KC Lee, KC Lee, L Rinaldi, LA Baker, M Habib, M Senzolo, M Yamaguchi, MJ McPhail, P Chowdary, R Jalan, R Kanel von, RT Stravitz, RT Stravitz, SJ Deventer van, SJ Munoz, SR Ostrowski, T Lisman, T Lisman, TE Warkentin, V Rewari   +39 more
core   +4 more sources

Lebein, a Snake Venom Disintegrin, Induces Apoptosis in Human Melanoma Cells

Toxins, 2016
Melanoma, the most threatening form of skin cancer, has a very poor prognosis and is characterized by its very invasive and chemoresistant properties.
Manel B. Hammouda, María F. Montenegro, Luis Sánchez-del-Campo, Ons Zakraoui, Zohra Aloui, Ichrak Riahi-Chebbi, Habib Karoui, José Neptuno Rodríguez-López, Khadija Essafi-Benkhadir   +8 more
doaj   +1 more source

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage [PDF]

, 2015
20 páginas, 4 figuras, 3 tablas y 7 tablas en material suplementario.Snake venom hemorrhagic metalloproteinases (SVMPs) of the PI, PII and PIII classes were compared in terms of tissue localization and their ability to hydrolyze basement membrane ...
A Osaka, A Rucavado, A Rucavado, AF Pinto, AK Oliveira, Alexandra Rucavado, AM Moura-da-Silva, AM Moura-da-Silva, Ana Moura, BG Fry, C Baldo, Cristina Herrera, DB Gould, Diego Morazán, E Camacho, EN Baramova, EN Baramova, EN Baramova, J Durban, Jay W. Fox, JJ Calvete, JM Gutiérrez, JM Gutiérrez, JM Gutiérrez, JM Gutiérrez, José María Gutiérrez, Juan J. Calvete, JW Fox, Jéssica Kele A. Macêdo, K Kühn, K Kühn, L Watanabe, Libia Sanz, Mathieu-Benoit Voisin, N Jiménez, NR Casewell, NR Casewell, NR Casewell, PD Yurchenco, PD Yurchenco, R Timpl, SM Serrano, SM Serrano, SM Serrano, Sussan Nourshargh, SV Costes, T Escalante, T Escalante, T Escalante, T Nikai, Teresa Escalante, UK Laemmli, WJ Wang   +52 more
core   +4 more sources

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J., Gay, Claudia Carolina, Pla, Davinia, Sanz, Libia   +3 more
core   +2 more sources

Integrins, cancer and snake toxins (mini-review)

Journal of Venomous Animals and Toxins including Tropical Diseases, 2005
Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM).
G. Rádis-Baptista
doaj   +1 more source

The role of proteases in pathologies of the synovial joint [PDF]

, 2008
Synovial (diarthrodial) joints are employed within the body to provide skeletal mobility and have a characteristic structure adapted to provide a smooth almost frictionless surface for articulation.
Buttle, D, Jones, GC, Riley, GP
core   +1 more source

A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via α5β1 Integrin Receptors to Arginine–Glycine–Aspartic Acid (RGD)-Containing Molecules

Toxins
Viperid snake venoms are notably abundant in metalloproteinases (proteins) (SVMPs), which are primarily responsible for inducing hemorrhage and disrupting the hemostatic process and tissue integrity in envenomed victims.
Pedro Henrique de Caires Schluga, Debora Larangote, Ana Maria de Melo, Guilherme Kamienski Lobermayer, Daniel Torrejón, Luciana Souza de Oliveira, Valeria Gonçalves Alvarenga, Dan Erick Vivas-Ruiz, Silvio Sanches Veiga, Eladio Flores Sanchez, Luiza Helena Gremski   +10 more
doaj   +1 more source

The Anti-Cancer Potency and Mechanism of a Novel Tumor-Activated Fused Toxin, DLM

Toxins, 2015
Melittin, which acts as a membrane-disrupting lytic peptide, is not only cytotoxic to tumors, but also vital to normal cells. Melittin had low toxicity when coupled with target peptides.
Dejun Sun, Miaonan Sun, Wenhe Zhu, Zhiding Wang, Yuefei Li, Jie Ma   +5 more
doaj   +1 more source

Immuno Magnetic Thermosensitive Liposomes For Cancer Therapy [PDF]

, 2019
The present work describes the encapsulation of the drug doxorubicin (DOX) in immuno paramagnetic thermosensitive liposomes. DOX is the most common chemotherapeutic agent for the treatment of a variety of carcinomas.
Alawak, Mohamad
core   +1 more source