Results 51 to 60 of about 62,920 (233)
The First Snake Venom KTS/Disintegrins-Integrin Interactions Using Bioinformatics Approaches
Molecules, 2022 Snake venom contains a number of active molecules that have been shown to possess high anti-tumor activities; disintegrins are an excellent example among these.
Oussema Khamessi +5 more
doaj +1 more source
Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies
Advanced Science, EarlyView.This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang +7 more
wiley +1 more source
Improvements in Endotoxemic Syndromes Using a Disintegrin, Rhodostomin, through Integrin Alpha V Beta 3-Dependent Pathway [PDF]
, 2012 Background and objectives: Septic shock is a major cause of morbidity and mortality in intensive care units, but there is still no effective therapy for the patients.
許竣傑;莊偉哲;張倩馨;曾昱綸;彭惠琴;黃德富 +1 more
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Isolation and in silico characterization of a leishmanicidal disintegrin from cerastes cerastes venom [PDF]
, 2018 International audienceBackground: Leishmaniasis represents a serious public health problem in Algeria. The parasite, in the promastigote form, upon transfer by the infected vector to the vertebrate host, invades mononuclear macrophages and causes ...
Allane, Dihia +5 more
core +1 more source
Role of ADAM and ADAMTS proteases in pathological tissue remodeling
Cell Death Discovery, 2023 Pathological tissue remodeling is closely associated with the occurrence and aggravation of various diseases. A Disintegrin And Metalloproteinases (ADAM), as well as A Disintegrin And Metalloproteinase with ThromboSpondin motifs (ADAMTS), belong to zinc ...
Zhaoni Wang +3 more
doaj +1 more source
Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research
American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley +1 more source
Molecular Medicine Reports, 2015 A disintegrin and metalloproteinases (ADAMs), a family of transmembrane glycoproteins, are expressed in numerous tissues and organs, and have been implicated in a variety of physiological and pathological processes. ADAM15 is unique among the ADAMs in having an Arg-Gly-Asp motif in its disintegrin domain.
Ying, Hou +8 more
openaire +3 more sources
Expression of ADAMs (“a disintegrin and metalloprotease”) in the human lung [PDF]
Virchows Archiv, 2009 In view of the associations of "a disintegrin and metalloprotease" (ADAM) with respiratory diseases, we assessed the expression of various ADAMs in human lung tissue. Lung tissue was obtained from nine individuals who underwent surgery for lung cancer or underwent lung transplantation for emphysema.
Dijkstra, Antoon +6 more
openaire +3 more sources
Biotechnology and Bioengineering, EarlyView.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source
Antiplatelet effect of recombinant human disintegrin [PDF]
, 2005 의학과/박사[한글] 급성 관동맥 증후군 등 혈전 관련 질환에서 혈소판의 glycoprotein (GP) IIb/IIIa 수용체 억제를 통한 혈소판응집 억제가 중요한 치료법으로 사용되고 있으나, 더 이상적인 항혈소판 약물에 대한 연구가 지속적으로 이루어지고 있다. GP IIb/IIIa 수용체에 대한 억제 효과가 있는 뱀독 디스인테그린과 구조가 유사한 A Disintegrin And Metalloproteinase (ADAM)이 최근 인체에서 ...
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