Results 11 to 20 of about 65,779 (239)

The Metalloprotease Disintegrin ADAM8 [PDF]

Journal of Biological Chemistry, 2002
ADAMs (a disintegrin and metalloprotease domains) are metalloprotease and disintegrin domain-containing transmembrane glycoproteins with proteolytic, cell adhesion, cell fusion, and cell signaling properties.
Uwe Schlomann, Dirk Wildeboer, Ailsa Webster, Olga Antropova, Dagmar Zeuschner, C. Graham Knight, Andrew J.P. Docherty, Marc Lambert, Lisa Skelton, Harald Jockusch, Jörg W. Bartsch   +10 more
core   +3 more sources

Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
Background In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can interact with specific integrins to
Isadora Sousa de Oliveira, Rafaella Varzoni Manzini, Isabela Gobbo Ferreira, Iara Aimê Cardoso, Karla de Castro Figueiredo Bordon, Ana Rita Thomazela Machado, Lusânia Maria Greggi Antunes, José Cesar Rosa, Eliane Candiani Arantes   +8 more
doaj   +2 more sources

Snake Venom Disintegrins and Cell Migration [PDF]

Toxins, 2010
Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement.
Heloisa S. Selistre-de-Araujo, Carmen L. S. Pontes, Cyntia F. Montenegro, Ana Carolina B. M. Martin   +3 more
doaj   +3 more sources

EVALUATING THE EFFECTS OF DISINTEGRIN ON TUMOUR GROWTH [PDF]

Biotechnologia Acta
Cancer is the second leading cause of death in the world after cardiovascular disease, and many types of cancer have no symptoms in the early stages, making it difficult to diagnose.
O. M. PLATONOV, Y. D. VINNYCHUK
doaj   +2 more sources

Three disintegrin-like domain mutations of ADAMTS13： functional deficiency and association with thrombosis [PDF]

Zhenduanxue lilun yu shijian
Objective To analyze the genotypic and phenotypic characteristics of four thrombotic patients carrying heterozygous mutations in the disintegrin-like domain of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs 13), and to ...
LIN Liya, WU Xi, MAO Yinqi, CHEN Guangming, WU Wenman, DAI Jing, WANG Xuefeng, DING Qiulan
doaj   +2 more sources

Recombinant and Chimeric Disintegrins in Preclinical Research

Toxins, 2018
Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake venoms of different phylogenetic origin. These peptides selectively bind to integrins, which are heterodimeric adhesion receptors that play a fundamental role in ...
Victor David, Barbara Barbosa Succar, João Alfredo de Moraes, Roberta Ferreira Gomes Saldanha-Gama, Christina Barja-Fidalgo, Russolina Benedeta Zingali   +5 more
doaj   +3 more sources

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

Zinc metalloproteinases and amyloid Beta-Peptide metabolism : the positive side of proteolysis in Alzheimer's disease [PDF]

, 2011
Alzheimer's disease is a neurodegenerative condition characterized by an accumulation of toxic amyloid beta- (Aβ-)peptides in the brain causing progressive neuronal death.
Gough, Mallory, Catherine Parr-Sturgess, Parr-Sturgess, Catherine, Edward Parkin, Mallory Gough, Parkin, Edward   +5 more
core   +5 more sources

Circulating Serum AGRN and ADAMTS8 With Related Candidates as Potential Biomarkers for Carotid Plaque Presence and Vulnerability. [PDF]

CNS Neurosci Ther
This study investigated serum AGRN and ADAMTS8 as biomarkers for carotid plaques within human participants. Results showed a significant correlation with plaque presence, yielding a moderate combined diagnostic performance. However, these markers poorly differentiated plaque vulnerability.
Guo S, Cui S, Zhang X, Xing Z, Sun Y, Qin M, Ma X, Li X, Ma Y, Gao P, Chen Y, Wang Y, Yang B, Chen J, Chen F, Lu X, Jin J, Jiao L, Wang T.   +18 more
europepmc   +2 more sources