Results 11 to 20 of about 62,920 (233)
The Metalloprotease Disintegrin ADAM8 [PDF]
Journal of Biological Chemistry, 2002 ADAMs (a disintegrin and metalloprotease domains) are metalloprotease and disintegrin domain-containing transmembrane glycoproteins with proteolytic, cell adhesion, cell fusion, and cell signaling properties.
Uwe Schlomann +10 more
core +5 more sources
ADAM-15 Disintegrin-Like Domain Structure and Function [PDF]
Toxins, 2010 The ADAM (a disintegrin-like and metalloproteinase) proteins are a family of transmembrane cell-surface proteins with important functions in adhesion and proteolytic processing in all animals.
Dong Lu +3 more
doaj +2 more sources
Snake Venom Disintegrins and Cell Migration [PDF]
Toxins, 2010 Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement.
Heloisa S. Selistre-de-Araujo +3 more
doaj +3 more sources
Cell migration inhibition activity of a non-RGD disintegrin from Crotalus durissus collilineatus venom [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2018 Background In recent decades, snake venom disintegrins have received special attention due to their potential use in anticancer therapy. Disintegrins are small and cysteine-rich proteins present in snake venoms and can interact with specific integrins to
Isadora Sousa de Oliveira +8 more
doaj +2 more sources
Three disintegrin-like domain mutations of ADAMTS13： functional deficiency and association with thrombosis [PDF]
Zhenduanxue lilun yu shijianObjective To analyze the genotypic and phenotypic characteristics of four thrombotic patients carrying heterozygous mutations in the disintegrin-like domain of ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motifs 13), and to ...
LIN Liya, WU Xi, MAO Yinqi, CHEN Guangming, WU Wenman, DAI Jing, WANG Xuefeng, DING Qiulan
doaj +3 more sources
EVALUATING THE EFFECTS OF DISINTEGRIN ON TUMOUR GROWTH [PDF]
Biotechnologia ActaCancer is the second leading cause of death in the world after cardiovascular disease, and many types of cancer have no symptoms in the early stages, making it difficult to diagnose.
O. M. PLATONOV, Y. D. VINNYCHUK
doaj +2 more sources
A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases [PDF]
Frontiers in Cardiovascular Medicine, 2020 Despite recent advances in treatment strategies, infectious diseases are still under the leading causes of death worldwide. Although the activation of the inflammatory cascade is one prerequisite of defense, persistent and exuberant immune response ...
Ahmad Aljohmani, Daniela Yildiz
doaj +3 more sources
Recombinant and Chimeric Disintegrins in Preclinical Research
Toxins, 2018 Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake venoms of different phylogenetic origin. These peptides selectively bind to integrins, which are heterodimeric adhesion receptors that play a fundamental role in ...
Victor David +5 more
doaj +3 more sources
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source