Results 11 to 20 of about 77,378 (253)
Snake Venom Disintegrins and Cell Migration [PDF]
Toxins, 2010 Cell migration is a key process for the defense of pluricellular organisms against pathogens, and it involves a set of surface receptors acting in an ordered fashion to contribute directionality to the movement.
Heloisa S. Selistre-de-Araujo +3 more
doaj +3 more sources
Computational Insights into Flavonoids for ADAMTS-5 Exosite Inhibition in Knee Osteoarthritis: Docking, MD Simulations, and Machine Learning-Guided Structure Prediction [PDF]
MoleculesThe limited selectivity of most catalytic-site ADAMTS-5 inhibitors and the necessity to preserve aggrecan integrity in early-grade knee osteoarthritis require the development of selective aggrecanase inhibitors.
Mayurakkhi Bhatia +2 more
doaj +2 more sources
EVALUATING THE EFFECTS OF DISINTEGRIN ON TUMOUR GROWTH [PDF]
Biotechnologia ActaCancer is the second leading cause of death in the world after cardiovascular disease, and many types of cancer have no symptoms in the early stages, making it difficult to diagnose.
O. M. PLATONOV, Y. D. VINNYCHUK
doaj +2 more sources
A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases [PDF]
Frontiers in Cardiovascular Medicine, 2020 Despite recent advances in treatment strategies, infectious diseases are still under the leading causes of death worldwide. Although the activation of the inflammatory cascade is one prerequisite of defense, persistent and exuberant immune response ...
Ahmad Aljohmani, Daniela Yildiz
doaj +3 more sources
Recombinant and Chimeric Disintegrins in Preclinical Research
Toxins, 2018 Disintegrins are a family of small cysteine-rich peptides, found in a wide variety of snake venoms of different phylogenetic origin. These peptides selectively bind to integrins, which are heterodimeric adhesion receptors that play a fundamental role in ...
Victor David +5 more
doaj +3 more sources
Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases [PDF]
Mediators of Inflammation, 2017 Cell migration is an instrumental process involved in organ development, tissue homeostasis, and various physiological processes and also in numerous pathologies.
D. Dreymueller +3 more
doaj +5 more sources
Hepatology, EarlyView., 2022 Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran +17 more
wiley +1 more source
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Disintegrins from Hematophagous Sources [PDF]
Toxins, 2012 Bloodsucking arthropods are a rich source of salivary molecules (sialogenins) which inhibit platelet aggregation, neutrophil function and angiogenesis. Here we review the literature on salivary disintegrins and their targets. Disintegrins were first discovered in snake venoms, and were instrumental in our understanding of integrin function and also for
Ivo M. B. Francischetti +2 more
openaire +3 more sources
Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom [PDF]
, 2018 Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic processing of PII and PIII classes of ...
Acosta, Ofelia Cristina +9 more
core +1 more source