Results 91 to 100 of about 65,779 (239)
Antiplatelet effect of recombinant human disintegrin
, 2005 의학과/박사[한글] 급성 관동맥 증후군 등 혈전 관련 질환에서 혈소판의 glycoprotein (GP) IIb/IIIa 수용체 억제를 통한 혈소판응집 억제가 중요한 치료법으로 사용되고 있으나, 더 이상적인 항혈소판 약물에 대한 연구가 지속적으로 이루어지고 있다. GP IIb/IIIa 수용체에 대한 억제 효과가 있는 뱀독 디스인테그린과 구조가 유사한 A Disintegrin And Metalloproteinase (ADAM)이 최근 인체에서 ...
이상학
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Plasma ADAMTS13 activity in healthy dogs and dogs with chronic enteropathy
Journal of Small Animal Practice, EarlyView.Objectives A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 is a von Willebrand factor cleaving enzyme that is associated with prothrombotic/hypercoagulable states in humans. In people, A disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 activity is reduced with inflammatory bowel disease ...
S. I. Barth +4 more
wiley +1 more source
Viper Venom Disintegrins and Related Molecules
Experimental Biology and Medicine, 1998 The term "disintegrin" was first used in 1990 to describe a group of viper venom-derived, nonenzymatic small proteins that shared numerous structural and functional properties. These proteins, which have been found in a great number of viper species studied since that time possess both a remarkable sequence homology and an equally notable variability ...
M A, McLane +4 more
openaire +2 more sources
Oral Diseases, EarlyView.ABSTRACT Objective This study aims to investigate the expression of invadopodia‐associated proteins—HIF‐1α, NOTCH‐1, ADAM‐12, and HB‐EGF—across different histological subtypes of unicystic ameloblastomas (UA) to assess their invasiveness under hypoxic conditions.
Gabriela Cristina Avertano Rocha da Silveira +14 more
wiley +1 more source
ADAM33: a cellular model of over-expression. From full length to soluble
Polymorphic variation in the A Disintegrin And Metalloprotease 33 (ADAM33) genehas been associated with asthma and bronchial hyperresponsiveness. The ADAMfamily of proteins has a multi-domain structure and has diverse biological functionswhich can ...
Harvey, Anna
core +1 more source
Dabsylated Bradykinin Is Cleaved by Snake Venom Proteases from Echis ocellatus
BiomedicinesThe vasoactive peptide bradykinin (BK) is an important member of the renin–angiotensin system. Its discovery is tightly interwoven with snake venom research, because it was first detected in plasma following the addition of viper venom.
Julius Abiola +4 more
doaj +1 more source
Toxins, 2016 The molecular events underlying the evolution of the Snake Venom Metalloproteinase (SVMP) family from an A Disintegrin And Metalloproteinase (ADAM) ancestor remain poorly understood.
Libia Sanz, Juan J. Calvete
doaj +1 more source
Inhibition of adipogenesis by RGD-dependent disintegrin
Biochemical Pharmacology, 2005 Adipogenesis plays a central role in obesity development. The processes of adipogenesis include migration, adhesion, proliferation and survival of preadipocytes and differentiation to mature adipocytes. Many of these biological functions are related to integrins.
Lin, Yu-Ting +5 more
openaire +2 more sources
New Insights Into Pathogenesis, Diagnostics, and Therapeutic Options for Canine Angiostrongylosis
Journal of Veterinary Emergency and Critical Care, EarlyView.ABSTRACT Objective To provide a comprehensive overview of Angiostrongylus vasorum infection in dogs, with a particular emphasis on recent developments in the understanding of disease pathophysiology and an update on developments in diagnostic and therapeutic options.
Iris Elgueta +3 more
wiley +1 more source
Regulatory effect of disintegrin on adipogenesis
, 2007 脂肪新生(adipogenesis)在肥胖的發展上扮演了很重要的角色，其過程包括前驅脂肪細胞的移動、附著、增生、生存及分化為成熟的脂肪細胞，而這些機能都和細胞上integrin的調控有關，於是我們利用由蛇毒中所純化出的disintegrin－trigramin、triflavin、rhodostomin－來探討它們對脂肪新生的影響。由實驗結果發現，disintegrin會造成初級前驅脂肪細胞及3T3-L1細胞株的脫落，並對focal adhesion產生影響，包括p-FAK ...
林玉婷, Lin, Yu-Ting
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