FUNCTION OF DISINTEGRIN-LIKE DOMAIN OF KSHV gB IN REGULATING VIRUS INFECTION [PDF]
, 2023 KSHV, also referred to as human herpesvirus-8 (HHV-8), is the eighth and latest identified human herpesvirus. It is the causative agent for a variety of malignancies namely Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric ...
Walker, Lia R. +1 more
core
Inflammatory effects of snake venom metalloproteinases
Memorias do Instituto Oswaldo Cruz, 2005 Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in the pathophysiology of envenomation, being responsible for local and systemic hemorrhage frequently observed in the victims.
Catarina de Fátima Pereira Teixeira +3 more
doaj +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Objective Soluble receptor for advanced glycation end‐products (sRAGE) and soluble Toll‐like receptor 4 (sTLR4) are circulating pattern recognition receptor isoforms implicated in inflammatory regulation in type 2 diabetes mellitus (T2DM). This study examined the effects of supervised aerobic exercise training (AET) on circulating sRAGE, sTLR4,
Ryan K. Perkins +9 more
wiley +1 more source
Cloning of Metalloprotease Genes in the Carpet Viper (Echis pyramidurm leakeyi): Further Members of the Metalloprotease/Disintegrin Gene Family: Further Members of the Metalloprotease/Disintegrin Gene Family [PDF]
, 1994 The genes coding for two metalloproteases, EcH‐I and EcH‐II, have been cloned from an Echis pyramidum leakeyi venom gland cDNA library. The cDNA sequences predict two zymogen molecules with strong amino acid sequence similarity and the same domain ...
Crampton, Julian M. +3 more
core +1 more source
Snake venom metalloproteinases and disintegrins: interactions with cells
Brazilian Journal of Medical and Biological Research, 1998 Metalloproteinases and disintegrins are important components of most viperid and crotalid venoms. Large metalloproteinases referred to as MDC enzymes are composed of an N-terminal Metalloproteinase domain, a Disintegrin-like domain and a Cys-rich C ...
Kamiguti A.S. +2 more
doaj
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Hepatology Research, EarlyView.ABSTRACT Aim The therapeutic significance of recombinant a disintegrin‐like and metalloprotease with thrombospondin type 1 motif 13 (rADAMTS13) in acute‐on‐chronic liver failure (ACLF) remains unclear. We aimed to investigate the therapeutic effects of rADAMTS13 in a murine model of ACLF‐like liver injury.
Jun‐ichi Hanatani +9 more
wiley +1 more source
Nucleotide sequence of a cDNA encoding a common precursor of disintegrin flavostatin and hemorrhagic factor HR2a from the venom of Trimeresurus flavoviridis [PDF]
, 1999 The venom of Trimeresurus flavoviridis has three disintegrins that act as platelet aggregation inhibitors by binding to integrin αIIbβ3 on platelets through its Arg-Gly-Asp sequence.
Shin, Yongchol +5 more
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Thirty Years of Autologous Platelet Concentrates: From Platelet‐Rich Plasma to Platelet‐Rich Fibrin
Journal of Periodontal Research, EarlyView.This review highlights the 30 years of evolution of APCs, with a focus on their clinical applications and recent technological advancements. ABSTRACT Nearly three decades have now passed since autologous platelet concentrates (APCs) were introduced into clinical practice.
Richard J. Miron +7 more
wiley +1 more source
A disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5) forms catalytically active oligomers [PDF]
, 2016 The metalloproteinase ADAMTS-5 (A disintegrin and metalloproteinase with thrombospondin motifs) degrades aggrecan, a proteoglycan essential for cartilage structure and function.
Russo, VC +10 more
core +1 more source