Results 91 to 100 of about 77,378 (253)

NKG2D and its ligands: one for all, all for one [PDF]

, 2018
The activating receptor NKG2D is peculiar in its capability to bind to numerous and highly diversified MHC class I-like self-molecules. These ligands are poorly expressed on normal cells but can be induced on damaged, transformed or infected cells, with ...
Cerboni, Cristina, Cippitelli, Marco, Fionda, Cinzia, Molfetta, Rosa, Paolini, Rossella, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +7 more
core   +2 more sources

Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion‐dependent β‐thalassaemia

British Journal of Haematology, EarlyView.
Summary Omics technologies have transformed research in haemoglobinopathies, yet the proteome of RBCs remains largely unexplored in transfusion‐dependent thalassaemia (TDT). In this proteomic analysis, Red blood cell (RBC) membranes from 48 adults with TDT were compared with healthy controls.
Konstantina Theocharaki, Sophia Delicou, Aikaterini Ntzoura‐Kani, Nikolaos Simantiris, Marianna Politou, Veroniki Komninaka, Martina Samiotaki, Jerome Zoidakis, Marianna H. Antonelou   +8 more
wiley   +1 more source

Phenotypic diversity of breast cancer-related mutations in metalloproteinase-disintegrin ADAM12. [PDF]

PLoS ONE, 2014
Six different somatic missense mutations in the human ADAM12 gene have been identified so far in breast cancer. Five of these mutations involve highly conserved residues in the extracellular domain of the transmembrane ADAM12-L protein.
Yue Qi, Sara Duhachek-Muggy, Hui Li, Anna Zolkiewska   +3 more
doaj   +1 more source

Secretion-Positive LGI1 Mutations Linked to Lateral Temporal Epilepsy Impair Binding to ADAM22 and ADAM23 Receptors [PDF]

, 2016
Autosomal dominant lateral temporal epilepsy (ADTLE) is a focal epilepsy syndrome caused by mutations in the LGI1 gene, which encodes a secreted protein.
Belluzzi, Elisa, Dazzo, Emanuela, Greggio, Elisa, Leonardi, Emanuela, Malacrida, Sandro, Nobile, Carlo, Tosatto, Silvio, Vitiello, Libero   +7 more
core   +3 more sources

Clinical burden and healthcare resource use of congenital thrombotic thrombocytopenic purpura in England: A linked primary and secondary care data analysis

British Journal of Haematology, EarlyView.
Summary Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra rare haematological disorder. This study aimed to estimate the clinical burden, healthcare resource use (HCRU) and associated costs of cTTP in England using primary and secondary care data. A retrospective cohort study was undertaken using the Clinical Practice Research Datalink (
Erin Barker, Will Lester, Heather Riley, Monica Garrett, Amie Padhiar, Annie Berkley, Sudhakar Manne, Umesh Doobaree, Oliver Heard   +8 more
wiley   +1 more source

Inflammatory effects of snake venom metalloproteinases

Memorias do Instituto Oswaldo Cruz, 2005
Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in the pathophysiology of envenomation, being responsible for local and systemic hemorrhage frequently observed in the victims.
Catarina de Fátima Pereira Teixeira, Cristina Maria Fernandes, Juliana Pavan Zuliani, Silvia Fernanda Zamuner   +3 more
doaj   +1 more source

The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad   +17 more
wiley   +1 more source

Snake venom metalloproteinases and disintegrins: interactions with cells

Brazilian Journal of Medical and Biological Research, 1998
Metalloproteinases and disintegrins are important components of most viperid and crotalid venoms. Large metalloproteinases referred to as MDC enzymes are composed of an N-terminal Metalloproteinase domain, a Disintegrin-like domain and a Cys-rich C ...
Kamiguti A.S., Zuzel M., Theakston R.D.G.   +2 more
doaj  

Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth [PDF]

, 2011
Disintegrins and disintegrins-like proteins are able to inhibit platelet aggregation and integrin-mediated cell adhesion. the aim of this study was to produce one disintegrin-like cloned from Bothrops leucurus venom gland and to characterize it regarding
Almeida, M. C., Araujo, Ronaldo Carvalho, Barros, C. C., Higuchi, D. A., Lang, E. A. S., Pesquero, J. L., Pesquero, João Bosco, Pesquero, P. R., Samaan, M., Sanchez, E. F.   +9 more
core   +2 more sources

Platelet Biochemistry and Morphology after Cryopreservation [PDF]

, 2020
Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle, Feys, Hendrik, Six, Katrijn   +2 more
core   +1 more source