Results 121 to 130 of about 78,401 (264)

Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer’s Disease Models

, 2021
Manli Zhong, Hejia Kou, Pu Zhao, Wei Zheng, He Xu, Xiaoyu Zhang, Wang Lan, Chuang Guo, Tao Wang, Feng Guo, Zhan‐You Wang, Huiling Gao   +11 more
openalex   +1 more source

Complex Mechanical Loading and Pro‐Inflammatory Cytokines in Intervertebral Disc Degeneration

JOR SPINE, Volume 9, Issue 1, March 2026.
This study investigated the combined effects of dynamic compression and torsion with major pro‐catabolic cytokine interleukin‐1 beta (IL‐1β) and its inhibitor: interleukin‐1 receptor antagonist (IL‐1Ra), on bovine IVD in an ex vivo organ culture system and further evaluated the mechanical effects using a subject‐personalized finite element model based ...
Katherine B. Crump, Estefano Muñoz‐Moya, Kim de Graaf, Paola Bermudez‐Lekerika, Nicole Schwendener, Wolf‐Dieter Zech, Christine L. Le Maitre, Jérôme Noailly, Benjamin Gantenbein   +8 more
wiley   +1 more source

Structures and Functions of Snake Venom Metalloproteinases (SVMP) from Protobothrops venom Collected in Japan

Molecules, 2017
Snake venom metalloproteinases (SVMP) are widely distributed among the venoms of Crotalinae and Viperidae, and are organized into three classes (P-I, P-II and P-III) according to their size and domain structure.
Etsuko Oyama, Hidenobu Takahashi
doaj   +1 more source

Conservation and divergence of ADAM family proteins in the Xenopus genome [PDF]

, 2010
Background Members of the disintegrin metalloproteinase (ADAM) family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins.
Bridges, Lance C., DeSimone, Douglas W., Shah, Anoop, Wei, Shuo, White, Judith M., Whittaker, Charles A., Xu, Guofeng   +6 more
core   +3 more sources

Evidence that peptides derived from the disintegrin domain of primate fertilin and containing the ECD motif block the binding of human spermatozoa to the zona‐free hamster oocyte [PDF]

, 1997
P. M. GICHUHI, W. C. L. Ford, L Hall
openalex   +1 more source

IKAROS Associated Immunodeficiency and Thrombotic Thrombocytopenic Purpura

Pediatric Blood &Cancer, Volume 73, Issue 2, February 2026.
ABSTRACT Pathogenic variants in IKZF1 (IKAROS) are linked to immunodeficiency, malignancy, and immune dysregulation. We describe a family with a rare IKZF1 variant presenting with humoral immunodeficiency and thrombotic thrombocytopenic purpura (TTP). A non‐consanguineous family was clinically monitored; clinical, immunological, and genetic data (exome
Ilia Spivak, Daniella Magen, Karin Weiss, Tamar Paperna, Suhair Hanna, Amos Etzioni, Adi Miller‐Barmak, Yonatan Butbul Aviel   +7 more
wiley   +1 more source

Tumor cytotoxicity of leucurolysin-B, a P-III snake venom metalloproteinase from Bothrops leucurus

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
Although it has been demonstrated that venoms and toxins from some snakes are able to influence the growth of tumor cells, few antitumoral compounds from Bothrops leucurus venom have been characterized.
LM Gabriel, EF Sanchez, SG Silva, RG Santos   +3 more
doaj   +1 more source

Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

Toxins, 2016
Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates in the tissues.
Erika Camacho, Libia Sanz, Teresa Escalante, Alicia Pérez, Fabián Villalta, Bruno Lomonte, Ana Gisele C. Neves-Ferreira, Andrés Feoli, Juan J. Calvete, José María Gutiérrez, Alexandra Rucavado   +10 more
doaj   +1 more source

Strategies to inhibit tumour associated integrin receptors: rationale for dual and multi-antagonists [PDF]

, 2014
YesThe integrins are a family of 24 heterodimeric transmembrane cell surface receptors. Involvement in cell attachment to the extracellular matrix, motility, and proliferation identifies integrins as therapeutic targets in cancer and associated ...
Albelda S. M., Amirkhosravi A., Aumailley M., Bandyopadhyay A., Barker P. L., Batt D. G., Bello L., Benfatti F., Bennett J. S., Bianchi-Smiraglia A., Bisanz K., Bochen A., Boys M. L., Bretschi M., Bretschi M., Brooks P. C., Buergy D., Burbridge M. F., Böger C., Calderwood D. A., Calvete J. J., Calvete J. J., Carey C. M., Chen Q., Chico T. J. A., Christoforides C., Chu F. M., Chung K.-H., Cohen S. A., Cox D., Dardik R., Davenport R. J., Davis F. B., De Corte B. L., De S., Dechantsreiter M. A., Dome B., Duan X. P., Engebraaten O., Engleman V. W., Erdreich-Epstein A., Friedlander M., Gasparini G., Gentilucci L., Gomes N., Goodman S. L., Goodman S. L., Goodman S. L., Hailey S., Harms J. F., Heidenreich A., Helen M. Sheldrake, Henderson N. C., Humphries J. D., Ishikawa M., Ishikawa M., Kang I.-C., Kerr J. S., Kim S., Knowles L. M., Kubota D., Kubota D., Kumar C. C., Laurence H. Patterson, Laurens N., Letourneau J. J., Lin E., Liu Y., Lonsdorf A. S., Lucena S. E., Malik G., Marelli U. K., Marinelli L., Marinelli L., Marinelli L., Martin P. L., Martin S., Mas-Moruno C., Mas-Moruno C., Matsuno H., Maubant S., Max R., McCabe N. P., Meerovitch K., Menendez J. A., Minea R., Minea R. O., Mitjans F., Morjen M., Mullamitha S. A., Naber H. P., Nabors L. B., Nadrah K., Nagae M., Oleksowicz L., Osterkamp F., O’Day S., O’Day S. J., Palumbo J. S., Parvani J. G., Pecheur I., Peishoff C. E., Perron-Sierra F., Pfaff M., Pontes-Júnior J., Reinmuth N., Reynolds A. R., Romanov V. I., Ross F. P., Scarborough R. M., Scarborough R. M., Scaringi C., Schaffner F., Schittenhelm J., Schittenhelm J., Schmieder A. H., Schneider J. G., Shannon K. E., Sheldrake H. M., Shih C.-H., Simon K. O., Sloan E. K., Smallheer J. M., Sowmya G., Stachurska A., Steri V., Stragies R., Sung V., Swenson S., Sánchez E. E., The IMPACT-II Investigators., Timar J., Tolomelli A., Topol E. J., Trabocchi A., Trikha M., Trikha M., Trikha M., Trikha M., van den Hoogen C., van der Flier A., van der Horst G., van der Horst G., Vermorken J. B., Vogetseder A., Wan A. M., Wu Y. J., Xiao T., Zhang W., Zhao F., Zhao Y.   +150 more
core   +1 more source

Down-Regulated Expression of A Disintegrin and Metalloproteinase with Thrombospondin-Like Repeats-1 by Progesterone Receptor Antagonist Is Associated with Impaired Expansion of Porcine Cumulus-Oocyte Complexes [PDF]

, 2004
Masayuki Shimada, Masahide Nishibori, Yasuhisa Yamashita, Junya Ito, Takahide Mori, JoAnne S. Richards   +5 more
openalex   +1 more source