Results 121 to 130 of about 51,218 (319)

c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells. [PDF]

, 2013
ObjectiveADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix.
Amanatullah, Derek F, Di Cesare, Paul E, Haudenschild, Dominik R, Hong, Eunmee, Yik, Jasper   +4 more
core   +2 more sources

Multimeric Disintegrin Protein Polymer Fusions That Target Tumor Vasculature

Biomacromolecules, 2014
Recombinant protein therapeutics have increased in number and frequency since the introduction of human insulin, 25 years ago. Presently, proteins and peptides are commonly used in the clinic.
S. M. Janib, Joshua A Gustafson, R. Minea, S. Swenson, Shuanglong Liu, M. Pastuszka, L. Lock, H. Cui, F. Markland, P. Conti, Zibo Li, J. A. MacKay   +11 more
semanticscholar   +1 more source

Metabolomic and proteomic stratification of equine osteoarthritis

Equine Veterinary Journal, EarlyView.
Abstract Background Equine osteoarthritis (OA) is predominantly diagnosed through clinical examination and radiography, leading to detection only after significant joint pathology. The pathogenesis of OA remains unclear and while many medications modify the disease's inflammatory components, no curative or reversal treatments exist.
James R. Anderson, Marie M. Phelan, Eva Caamaño‐Gutiérrez, Peter D. Clegg, Luis M. Rubio‐Martinez, Mandy J. Peffers   +5 more
wiley   +1 more source

Emerging Roles of ADAM and ADAMTS Metalloproteinases in Cancer [PDF]

, 2008
A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs).
Cataldo, Didier, Crahay, Céline, El Hour, Mehdi, Foidart, Jean-Michel, Guéders, Maud, Noël, Agnès, Paulissen, Geneviève, Quesada Calvo, Florence, Rocks, Natacha   +8 more
core   +1 more source

Insights into the Evolution of a Snake Venom Multi-Gene Family from the Genomic Organization of Echis ocellatus SVMP Genes

Toxins, 2016
The molecular events underlying the evolution of the Snake Venom Metalloproteinase (SVMP) family from an A Disintegrin And Metalloproteinase (ADAM) ancestor remain poorly understood.
Libia Sanz, Juan J. Calvete
doaj   +1 more source

Fatty‐acid amide hydrolase inhibition mitigates Alzheimer's disease progression in mouse models of amyloidosis

The FEBS Journal, EarlyView.
Enhancing endocannabinoid signaling by targeting FAAH effectively mitigates cognitive deficits, reduces amyloid pathology, and modulates neuroinflammatory responses in a preclinical model of Alzheimer's disease. This effect is potentially mediated by attenuating the Aβ‐induced overexpression of the Bace1 gene through CB1‐dependent hypermethylation of ...
Sergio Oddi, Lucia Scipioni, Antonio Totaro, Giacomo Giacovazzo, Francesca Ciaramellano, Daniel Tortolani, Alessandro Leuti, Rita Businaro, Federica Armeli, Andras Bilkei‐Gorzo, Roberto Coccurello, Andreas Zimmer, Mauro Maccarrone   +12 more
wiley   +1 more source

Primary cilia disassembly down-regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]

, 2014
SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
core   +2 more sources

ADAMTS-1: A Cellular Disintegrin and Metalloprotease with Thrombospondin Motifs Is a Target for Parathyroid Hormone in Bone [PDF]

, 2000
Rebecca R. Miles, James P. Sluka, David L. Halladay, Robert F. Santerre, Laura V. Hale, Laura J. Bloem, Kannan Thirunavukkarasu, Rachelle J. Sells Galvin, Janet M. Hock, J.E. Onyia   +9 more
openalex   +2 more sources

Dabsylated Bradykinin Is Cleaved by Snake Venom Proteases from Echis ocellatus

Biomedicines
The vasoactive peptide bradykinin (BK) is an important member of the renin–angiotensin system. Its discovery is tightly interwoven with snake venom research, because it was first detected in plasma following the addition of viper venom.
Julius Abiola, Anna Maria Berg, Olapeju Aiyelaagbe, Akindele Adeyi, Simone König   +4 more
doaj   +1 more source

A Disintegrin and Metalloprotease (ADAM) 10 and ADAM17 Are Major Sheddases of T Cell Immunoglobulin and Mucin Domain 3 (Tim-3)*

Journal of Biological Chemistry, 2013
Background: Membrane-bound Tim-3 regulates immune responses. Results: Soluble Tim-3 is generated by A disintegrin and metalloprotease (ADAM) 10 and ADAM17. Conclusion: ADAM proteases are involved in Tim-3 processing.
Katja Möller-Hackbarth, Christin Dewitz, Olga Schweigert, A. Trad, Christoph Garbers, S. Rose-John, J. Scheller   +6 more
semanticscholar   +1 more source