The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25
The FEBS Journal, EarlyView.Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted proteases, including ADAMTS family members. Rainero and colleagues found that the small GTPase Rab25 promoted the expression of ADAMTS5 in ovarian cancer cells through the activation of the NF‐κB signalling pathway.
Shengnan Yuan +7 more
wiley +1 more source
Inhibition of interleukin-1β-stimulated collagenase and stromelysin expression in human tendon fibroblasts by epigallocatechin gallate ester [PDF]
, 2004 The medicinal benefits of green tea (Camellia sinensis) consumption have been attributed to bioavailable polyphenols, notably epigallocatechin gallate (EGCG).
Buttle, David J. +4 more
core +1 more source
Phosphatidylserine exposure is required for ADAM17 sheddase function
Nature Communications, 2016 ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells.
Anselm Sommer +18 more
doaj +1 more source
Journal of Biological Chemistry, 2013 Background: MicroRNA (miR) dysregulation is found in Alzheimer disease (AD). A disintegrin and metalloprotease 10 (ADAM10) prevents generation of amyloid β (Aβ) and decrease AD pathology.
Cong Cheng +6 more
semanticscholar +1 more source
The FEBS Journal, EarlyView.The tumor microenvironment (TME), particularly the extracellular matrix (ECM), plays a critical role in cancer progression. Focusing on ovarian cancer, Yuan et al. reveal an ECM‐dependent signaling axis where cancer‐associated fibroblasts (CAFs) enhance the invasiveness of cancer cells via Rab25‐driven upregulation of the protease ADAMTS5. This process
François Tyckaert, Francesco Baschieri
wiley +1 more source
Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]
, 2019 Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core
Expression of A disintegrin and metalloprotease 10 in pancreatic carcinoma
International Journal of Molecular Medicine, 2010 The protease ADAM10 influences progression and metastasis of cancer cells and is overexpressed in various malignancies. Therefore, the aim of our study was to evaluate the expression and potential function of ADAM10 in the pathophysiology of pancreatic cancer (PDAC).
Moritz N. Wente +8 more
openaire +4 more sources
Association of the IL‐6R rs2228145 polymorphism with diabetic nephropathy: A case‐control study
Journal of Diabetes Investigation, EarlyView.ABSTRACT Introduction The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin‐6 (IL‐6); IL‐6 triggers intracellular pathways through interaction with the IL‐6 receptor (IL‐6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL‐6 −597G/A ...
Pavla Izakovicova +7 more
wiley +1 more source
Activation of leukocyte rolling by the cysteine-rich domain and the hyper-variable region of HF3, a snake venom hemorrhagic metalloproteinase [PDF]
, 2008 The functionality of the disintegrin-like/cysteine-rich domains of snake venom metalloproteinases (SVMPs) has been shown to reside in the cysteine-rich region, which can interact with VWA-containing proteins.
Bruni, Fernanda M. +10 more
core +1 more source
Metalloprotease–disintegrin ADAM 12 binds to the SH3 domain of Src and activates Src tyrosine kinase in C2C12 cells [PDF]
, 2000 Qing Kang, Yi Cao, Anna Żółkiewska
openalex +2 more sources