Results 151 to 160 of about 51,218 (319)

Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth [PDF]

, 2011
Disintegrins and disintegrins-like proteins are able to inhibit platelet aggregation and integrin-mediated cell adhesion. the aim of this study was to produce one disintegrin-like cloned from Bothrops leucurus venom gland and to characterize it regarding
Almeida, M. C., Araujo, Ronaldo Carvalho, Barros, C. C., Higuchi, D. A., Lang, E. A. S., Pesquero, J. L., Pesquero, João Bosco, Pesquero, P. R., Samaan, M., Sanchez, E. F.   +9 more
core   +2 more sources

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders

Frontiers in Cellular Neuroscience, 2017
The extracellular matrix (ECM) and membrane proteolysis play a key role in structural and functional synaptic plasticity associated with development and learning.
Patrycja Brzdak, Patrycja Brzdak, Daria Nowak, Daria Nowak, Grzegorz Wiera, Grzegorz Wiera, Jerzy W. Mozrzymas, Jerzy W. Mozrzymas   +7 more
doaj   +1 more source

MDC-L, a Novel Metalloprotease Disintegrin Cysteine-rich Protein Family Member Expressed by Human Lymphocytes [PDF]

, 1999
Charles M. Roberts, P Tani, Lance C. Bridges, Zoltán Lászik, Ron D. Bowditch   +4 more
openalex   +1 more source

FIGO guideline on liver disease and pregnancy

International Journal of Gynecology &Obstetrics, Volume 170, Issue 1, Page 28-48, July 2025.
Abstract The number of women entering pregnancy with chronic liver disease is rising. Gestational liver disorders affect 3% of the pregnant population. Both can be associated with significant maternal and fetal morbidity and mortality. European guidance has recently been published to inform management.
Melanie Nana, Virna Medina, Cynthia Maxwell, Ciara McCormick, Gloria Taliani, Ulrich Beuers, Deborah Money, Bo Jacobsson, Anil Kapur, Titus Beyuo, Francisco Ruiloba, Graeme Smith, Lina Bergman, Sharleen O'Reilly, Patrick O'Brien, Mark Hanson, Mary Rosser, Claudio Sosa, Sumaiya Adam, Valerie Guinto, Liona Poon, Fionnuala McAuliffe, Catherine Williamson, on behalf of the FIGO Committee on Impact of Pregnancy on Long‐term Health, FIGO Committee on Infections during Pregnancy and the FIGO Division of Maternal and Newborn Health   +24 more
wiley   +1 more source

Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer [PDF]

, 2016
Prostate cancer is one of the most prevalent cancers inmen. It is critical to identify and characterize oncogenes that drive the pathogenesis of human prostate cancer.
Boulos, S, Epis, M, Hoyne, G, Johnson, L, Leedman, P, Matthews, V, McLaughlin, C, Mochizuki, S, Okada, Y, Rudnicka, C, Schlaich, M, Stuart, L   +11 more
core   +2 more sources

Presumed antiphospholipid syndrome and thrombotic thrombocytopenic purpura: An infrequent association

Clinical Case Reports, 2019
Antiphospholipid syndrome (APS) is an autoimmune disease that demonstrates antiphospholipid antibodies that cause hypercoagulability and leads to venous and arterial thrombosis. Autoantibodies to a disintegrin‐like and metalloprotease with thrombospondin
Hallie Hanna Dolin, Mark Dziuba, Scott M. Pappada, Thomas John Papadimos   +3 more
doaj   +1 more source

Evidence for an interaction of the metalloprotease–disintegrin tumour necrosis factor α convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease–disintegrin MDC9 with a novel MAD2-related protein, MAD2β [PDF]

, 1999
Karen K. Nelson, Johannes Schlöndorff, Carl Blobel   +2 more
openalex   +1 more source

Proteomics Reveals Increased Periostin in Synovial Fluid From Canine and Human Anterior Cruciate Ligament Injury

Journal of Orthopaedic Research, Volume 43, Issue 7, Page 1239-1249, July 2025.
ABSTRACT Posttraumatic osteoarthritis (PTOA) is a common sequela to anterior cruciate ligament (ACL) injury in humans and dogs. Identification of conserved targets between species may hasten biomarker identification and therapeutic development. To identify differentially regulated synovial fluid (SF) proteins in ACL injury, SF samples were collected ...
Sydney J. Womack, Camila B. Carballo, Erica J. Secor, Scott A. Rodeo, Heidi L. Reesink   +4 more
wiley   +1 more source

Human Metalloprotease-Disintegrin Kuzbanian Regulates Sympathoadrenal Cell Fate in Development and Neoplasia [PDF]

, 1998
Reza Yavari, Colette Adida, Patricia Bray‐Ward, Michael Brines, Tian Xu   +4 more
openalex   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, Volume 19, Issue 6, Page 1612-1632, June 2025.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source