Determination of the microscopic acid dissociation constant of piperacillin and identification of dissociated molecular forms [PDF]
Frontiers in Chemistry, 2023 For amphoteric ß-lactam antibiotics, the acid dissociation constant (pKa) is a fundamental parameter to characterize physicochemical and biochemical properties of antibiotics and to predict persistence and removal of drugs.
Guoao Li +5 more
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Simple methods to determine the dissociation constant, K<sub>d</sub>. [PDF]
Mol CellsThe determination of the dissociation constant (Kd) is pivotal in biochemistry and pharmacology for understanding binding affinities in chemical reactions, which is crucial for drug development and comprehending biological systems.
Lee D, Kim J, Lee G.
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Dissociation Constant (K<sub>d</sub>) Measurement for Small-Molecule Binding Aptamers: Homogeneous Assay Methods and Critical Evaluations. [PDF]
Small MethodsSince 1990, numerous aptamers have been isolated and discovered for use in various analytical, biomedical, and environmental applications. This trend continues to date.
Stangherlin S, Ding Y, Liu J.
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Optimization of Electrospray Ionization by Statistical Design of Experiments and Response Surface Methodology: Protein-Ligand Equilibrium Dissociation Constant Determinations. [PDF]
J Am Soc Mass Spectrom, 2016 Electrospray ionization mass spectrometry (ESI-MS) binding studies between proteins and ligands under native conditions require that instrumental ESI source conditions are optimized if relative solution-phase equilibrium concentrations between the ...
Pedro L, Van Voorhis WC, Quinn RJ.
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Calculation of Crystal-Solution Dissociation Constants [PDF]
Biomolecules, 2022 The calculation of dissociation constants is an important problem in molecular biophysics. For such a calculation, it is important to correctly calculate both terms of the binding free energy; that is, the enthalpy and entropy of binding.
Sergiy O. Garbuzynskiy +1 more
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Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction. [PDF]
J Vis Exp, 2018 Eble JA.
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Overview of the detection methods for equilibrium dissociation constant KD of drug-receptor interaction. [PDF]
J Pharm Anal, 2018 Ma W, Yang L, He L.
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The Kinetics of Chitosan Degradation in Organic Acid Solutions
Marine Drugs, 2021 This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics. More precisely, the aim of the study was to determine the kinetics of the degradation process depending ...
Dominik Sikorski +2 more
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SYNTHESIS AND IDENTIFICATION OF SOME HYDROXAMIC DERIVATIVES AND STUDYING THEIR THERMO AND PHOTO DEGRADATION [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2014 The aim of this research is to prepare and study the kinetics effect of temperature and photochemical reactions of the hydroxamic acid derivatives of diethyl succinate through the interaction of alkyl halides and diethyl succinate in the presence of ...
ISMAIL AL-KHATEEB +2 more
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Separations, 2021 The dissociation constant is an important physicochemical property of drug molecules that affects the pharmacokinetic and pharmacodynamic properties of drugs.
Wanying Wang +5 more
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