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Determination of the microscopic acid dissociation constant of piperacillin and identification of dissociated molecular forms [PDF]
Frontiers in Chemistry, 2023 For amphoteric ß-lactam antibiotics, the acid dissociation constant (pKa) is a fundamental parameter to characterize physicochemical and biochemical properties of antibiotics and to predict persistence and removal of drugs.
Guoao Li +5 more
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Simple methods to determine the dissociation constant, Kd [PDF]
Molecules and Cells: The determination of the dissociation constant (Kd) is pivotal in biochemistry and pharmacology for understanding binding affinities in chemical reactions, which is crucial for drug development and comprehending biological systems. Here, we introduce a
Donghun Lee, Juwon Kim, Gwangrog Lee
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Calculation of Crystal-Solution Dissociation Constants [PDF]
Biomolecules, 2022 The calculation of dissociation constants is an important problem in molecular biophysics. For such a calculation, it is important to correctly calculate both terms of the binding free energy; that is, the enthalpy and entropy of binding.
Sergiy O. Garbuzynskiy +1 more
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SYNTHESIS AND IDENTIFICATION OF SOME HYDROXAMIC DERIVATIVES AND STUDYING THEIR THERMO AND PHOTO DEGRADATION [PDF]
مجلة جامعة الانبار للعلوم الصرفة, 2014 The aim of this research is to prepare and study the kinetics effect of temperature and photochemical reactions of the hydroxamic acid derivatives of diethyl succinate through the interaction of alkyl halides and diethyl succinate in the presence of ...
ISMAIL AL-KHATEEB +2 more
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The Kinetics of Chitosan Degradation in Organic Acid Solutions
Marine Drugs, 2021 This paper presents a comparative study on chitosan degradation in organic acid solutions according to their different dissociation characteristics. More precisely, the aim of the study was to determine the kinetics of the degradation process depending ...
Dominik Sikorski +2 more
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Separations, 2021 The dissociation constant is an important physicochemical property of drug molecules that affects the pharmacokinetic and pharmacodynamic properties of drugs.
Wanying Wang +5 more
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Determination of pKa values of fluphenazine analogs by reversed-phase high-performance liquid chromatography [PDF]
Acta Poloniae Pharmaceutica, 2023 Phenothiazine and its derivatives exhibit many properties. Hence they are the starting structures for many new potential drugs, biologically active compounds, dyes, etc.
Sobczak Agnieszka +3 more
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Favipiravir Determination in Pharmaceutical Formulation via HPLC Chromatographic Approach [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2023 Favipiravir is a broad-spectrum antiviral drug and it has increasing interest regarding its potential use in Covid-19 therapy. In the present work, a simple, fast, precise Reverse-Phase High-Performance Liquid Chromatography (RP-HPLC) technique was ...
Sabriye Aydinoglu, Metin Bozyel
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Frontiers in Bioscience-Landmark, 2022 Background: Diazinon is a widely used organophosphorus neurotoxic insecticide. It is a common environmental contaminant and a hazardous agri-waste. Its detection is critical to control entry into food systems and protect the environment. Methods: In this
Mai-Huong Thi Can +11 more
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Phosphorylated and Phosphomimicking Variants May Differ—A Case Study of 14-3-3 Protein
Frontiers in Chemistry, 2022 Protein phosphorylation is a critical mechanism that biology uses to govern cellular processes. To study the impact of phosphorylation on protein properties, a fully and specifically phosphorylated sample is required although not always achievable ...
Aneta Kozeleková +10 more
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