Results 41 to 50 of about 1,952,840 (306)
, 2014 N – Number of binding sites, ΔH – Change in enthalpy, ΔS – Change in entropy, Ka – Association constant, Kd – Dissociation constant, KD – Global dissociation constant.
Pasham Parameshwar Reddy (603740) +7 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Biosensors, 2020 Affinity characterization is essential to develop reliable aptamers for tumor biomarker detection. For alpha-fetoprotein (AFP), a biomarker of hepatocellular carcinoma (HCC), two DNA aptamers were described with very different affinity.
Ramón Lorenzo-Gómez +4 more
doaj +1 more source
Sequence, dissociation constant and stoichiometry of oligonucleotides derived from S15.
, 2015 Sequence, dissociation constant and stoichiometry of oligonucleotides derived from S15.
Suh-Chin Wu (88404) +4 more
core +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Direct Potentiometric Determination of Fluoride Species by Using Ion-Selective Fluoride Electrode
International Journal of Electrochemical Science, 2012 A novel approach and method for potentiometric determination of acid dissociation constant (Ka) of hydrofluoric acid are described. Proposed method is based on using commercial fluoride ISE (FISE) as very inexpensive, simple and reasonably fast method ...
Ante Prkić +3 more
doaj +1 more source
Potentiometric investigation of acid-base equilibria of two new pyrimidine derivatives in various methanol-water media [PDF]
Journal of the Serbian Chemical Society, 2006 The acid-base properties of 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-one (L1) and 1-amino-5-benzoyl-4-phenyl-1H-pyrimidine-2-thione (L2) were investigated potentiometrically at an ionic strength of 0.10M(LiCl) in 19.8, 33.6 and 55.9 % (v/v) methanol ...
Kiliç Hasan, Birol Er
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Computer programs for calculating pKa: a comparative study for 3-(3-(2-nitrophenyl)prop-2-enoyl)-2H-1-benzopyran-2-one [PDF]
Journal of the Serbian Chemical Society, 2010 Coumarin-based compounds containing a chalcone moiety exhibit antimicrobial activity. These substances are potential drugs and it is important to determine their pKa values. However, they are almost insoluble in water.
SELMA ŠPIRTOVIĆ-HALILOVIĆ +1 more
doaj