A modified RP-HPLC method for the determination of the pKa values of synthesized β-hydroxy-β-arylalkanoic acids [PDF]
Journal of the Serbian Chemical Society, 2018 The pKa values of twelve β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using a modified RP-HPLC method. The stationary phase was octadecyl modified (C-18) silica gel, and the mobile phases were mixtures of methanol and one of ten different
Savić Jelena S. +4 more
doaj +1 more source
Time delay as a key to Apoptosis Induction in the p53 Network
, 2002 A feedback mechanism that involves the proteins p53 and mdm2, induces cell death as a controled response to severe DNA damage. A minimal model for this mechanism demonstrates that the respone may be dynamic and connected with the time needed to translate
Jensen, M. H., Sneppen, K., Tiana, G.
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
The Mutagenic Plasticity of the Cholera Toxin B-Subunit Surface Residues: Stability and Affinity
ToxinsMastering selective molecule trafficking across human cell membranes poses a formidable challenge in healthcare biotechnology while offering the prospect of breakthroughs in drug delivery, gene therapy, and diagnostic imaging. The cholera toxin B-subunit
Cheuk W. Au +5 more
doaj +1 more source
Bottomonium dissociation in a finite density plasma
, 2017 We present a holographic description of the thermal behavior of $ b \bar b$ heavy vector mesons inside a plasma at finite temperature and density. The meson dissociation in the medium is represented by the decrease in the height of the spectral function ...
Braga, Nelson R. F., Ferreira, Luiz F.
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Perhitungan Energi Disosiasi Gugus Fungsi OH- dan PO4 3- Hidroksiapatit dengan Pemodelan Spektroskopi Inframerah Berbasis Particle Swarm Optimization (PSO) [PDF]
, 2013 ABSTRAK Hydroxyapatite Ca10(PO4)6(OH)2 is a calcium phosphate compound having biocompatibility properties. FTIR (Fourier Transform Infrared Spectroscopy) was used to determine the characteristics of the hydroxyapatite group.
Dahlan, Kiagus +2 more
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The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Interaction of GB1 with Metal Ions Studied by NMR Spectroscopy
Chinese Journal of Magnetic Resonance, 2018 B1 domain of staphylococcal protein G (GB1) is a widely used model protein for developing in vivo and in vitro protein structural determination methods based on paramagnetic nuclear magnetic resonance (NMR) such as pseudocontact chemical shift (PCS) and ...
CHENG Kai +3 more
doaj +1 more source
Physiological Reports, 2021 The purpose of this investigation was to present calculations of fractional H+ exchange (~H+e) from the chemical reactions of non‐mitochondrial energy catabolism.
Robert A. Robergs
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Kinetic and Structural Analysis of the Mg2+ -binding Site of the Guanine Nucleotide-binding Protein p21 H-ras. [PDF]
, 1993 The coordination and binding of the Mg2+ ion in the nucleotide−binding site of p21 have been investigated using site−directed mutagenesis, kinetic methods, and phosphorous NMR.
Borasio, Gian Domenico +6 more
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