Results 71 to 80 of about 226,875 (303)
A Contribution to the Glimepiride Dissociation Constant Determination [PDF]
, 2010 Knowledge of druglike properties, such as dissociation constants (pK(a)), is of great importance in drug development and analysis. However, poor aqueous Solubility often Causes serious limitations ill accurate determination of a drug's pK(a).
Parojčić, Jelena +9 more
core +1 more source
Interaction of GB1 with Metal Ions Studied by NMR Spectroscopy
Chinese Journal of Magnetic Resonance, 2018 B1 domain of staphylococcal protein G (GB1) is a widely used model protein for developing in vivo and in vitro protein structural determination methods based on paramagnetic nuclear magnetic resonance (NMR) such as pseudocontact chemical shift (PCS) and ...
CHENG Kai +3 more
doaj +1 more source
A modified RP-HPLC method for the determination of the pKa values of synthesized β-hydroxy-β-arylalkanoic acids [PDF]
Journal of the Serbian Chemical Society, 2018 The pKa values of twelve β-hydroxy-β-arylalkanoic acids and ibuprofen were determined using a modified RP-HPLC method. The stationary phase was octadecyl modified (C-18) silica gel, and the mobile phases were mixtures of methanol and one of ten different
Savić Jelena S. +4 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Acid Dissociation Constant of Streptomycin Perchlorate and Stability Constant of its Complex with Copper(II) [PDF]
, 1975 Shri G. S. Institute of Technology and Science, Indore Manuscript received 18 December 1973; revised 12 November 1974; accepted 11 December 1974 The acid dissociation constant of streptomycin perchlorate and the stability constant of its Cu(II) complex
R. VIJAYVARGIYA, J. K. AGRAWAL
core +1 more source
Physiological Reports, 2021 The purpose of this investigation was to present calculations of fractional H+ exchange (~H+e) from the chemical reactions of non‐mitochondrial energy catabolism.
Robert A. Robergs
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The dissociation constant of aptamer binding to C4-HSL by saturation binding model. [PDF]
, 2019 The dissociation constant of aptamer binding to C4-HSL by saturation binding model.
Meng Zhao (54299) +4 more
core +1 more source
Selection and Characterization of DNA Aptamers for Egg White Lysozyme
Molecules, 2010 We have selected aptamers binding to lysozyme from a DNA library using capillary electrophoresis-systematic evolution of ligands by exponential enrichment.
Jeroen Lammertyn +6 more
doaj +1 more source