Results 81 to 90 of about 1,952,840 (306)
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Determination of dissociation constant of alkaloids by gradient elution system using UPLC
, 2007 Dissociation constant is a very important physical chemical parameter to the compounds. It contributes to an understanding of many phenomena such as reaction rates, biological uptake, transport, environmental fate. There are many methods to determine the
金郁, 肖远胜, 张静, 梁鑫淼
core
, 2014 Effects of ionic strength and amino acid substitutions on the dissociation constant for AggAdsA-fibronectin binding.
Natalia Pakharukova (631544) +15 more
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
The Dissociation Constants of Arginine [PDF]
Biochemical Journal, 1924 A, Hunter, H, Borsook
openaire +2 more sources
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Macedonian Journal of Chemistry and Chemical Engineering, 2006 The behaviour of some newly synthesized derivatives of 1,2,4-triazoline-3-thione (4-butyl-5-octyl-2,4-dihydro-3H-1,2,4-triazoline-3-thione, 4-allyl-5-octyl-2,4-dihydro-3H-1,2,4-triazoline-3-thione, 4-phenyl-5-octyl-2,4- dihydro-3H-1,2,4-triazoline-3 ...
Mirjana Jankulovska +2 more
doaj
PLoS ONE, 2011 To understand the underlying mechanisms of significant differences in dissociation rate constant among different inhibitors for HIV-1 protease, we performed steered molecular dynamics (SMD) simulations to analyze the entire dissociation processes of ...
Dechang Li +3 more
doaj +1 more source