Results 81 to 90 of about 226,875 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Dissociation constant (K_d) of PNP-AV binding to cells. [PDF]

, 2013
Dissociation constant (Kd) of PNP-AV binding to cells.
John J. Krais (466121), Olivier De Crescenzo (466122), Roger G. Harrison (466123)   +2 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Thermodynamics, stoichiometry, and dissociation constant of albumin with GML, lauric acid or glycerol. [PDF]

, 2016
Thermodynamics, stoichiometry, and dissociation constant of albumin with GML, lauric acid or glycerol.
Michael S. Zhang (3233793), Jon C. D. Houtman (291993)   +1 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The dissociation constant of aptamer binding to C4-HSL by saturation binding mode. [PDF]

, 2019
The dissociation constant of aptamer binding to C4-HSL by saturation binding mode.
Meng Zhao (54299), Kuancan Liu (3834220), Huiling Li (260350), Xiaopeng Lan (3834226), Weibin Li (331743)   +4 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Aptamer sequences and their dissociation constant (Kd_s) aptamers and pool %. [PDF]

, 2012
Aptamer sequences and their dissociation constant (Kds) aptamers and pool %.
Hui William Chen (126042), Elizabeth Jiménez (126035), Melvyn S. Tockman (126044), Dalia López-Colón (126038), Kwame Sefah (126037), Weihong Tan (9692), Dimitri Van Simaeys (126039)   +6 more
core   +1 more source

THE DETERMINATION OF THE 2ND DISSOCIATION-CONSTANT OF SULFURIC-ACID [PDF]

, 1994
The second dissociation constant of sulfuric acid is determined in 1M NaClO4 at 25-degrees-C using an electrochemical cell without liquid junction consisting of a glass and a perchlorate electrode.
LUTS, Peter, VANHEES, J, VAN POUCKE, Lucien, YPERMAN, Jan, MULLENS, Jules   +4 more
core   +2 more sources