Dissolution improvement of binary solid dispersions of erlotinib prepared by one-step electrospray method. [PDF]
Biol Methods Protoc, 2022 Erlotinib hydrochloride, a selective tyrosine kinase inhibitor approved for treatment of non-small cell lung cancer firstly. Erlotinib classified as class II drugs in the Biopharmaceutical Classification System (BCS), which characterized by low ...
Jahangiri A, Khalilzad F, Barghi L.
europepmc +2 more sources
Binary Mixtures of Some Active Pharmaceutical Ingredients with Fatty Alcohols-The Criteria of Successful Eutectic Formation and Dissolution Improvement. [PDF]
Pharmaceutics, 2020 Pharmaceutical eutectics are solid mixtures, where the crystals of active pharmaceutical ingredients (APIs) are finely divided in the phase-separated microstructures.
Jin S, Jang J, Lee S, Kim IW.
europepmc +2 more sources
Ground Calcium Carbonate as a Low Cost and Biosafety Excipient for Solubility and Dissolution Improvement of Praziquantel. [PDF]
Pharmaceutics, 2019 Calcium carbonate is an abundant mineral with several advantages to be a successful carrier to improve oral bioavailability of poorly water-soluble drugs, such as praziquantel.
Borrego-Sánchez A +6 more
europepmc +2 more sources
Preparation And Characterization Of Nimesulide Nanoparticles For Dissolution Improvement
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2018 Nimesulide is one of the types of non-steroidal anti-inflammatory drugs, widely used as analgesic and antipyretic. It is classified as class II drugs according to BCS guidance because of low solubility in water that leads to decrease in dissolution rate.
Inas F. Abd-AlRazaq +2 more
doaj +2 more sources
Preparation and characterization of domperidone nanoparticles for dissolution improvement
Iraqi Journal of Pharmaceutical Sciences, 2018 This study was carried out to prepare and characterize domperidone nanoparticles to enhance solubility and the release rate. Domperidone is practically insoluble in water and has low and an erratic bioavailability range from 13%-17%.
Mohammed Sabar Al-lami +2 more
doaj +2 more sources
SOLUBILITY ENHANCEMENT AND DISSOLUTION IMPROVEMENT- LIQISOLID TECHNIQUE
Journal of Drug Delivery and Therapeutics, 2013 This technique is based upon the admixture of drug loaded solutions with appropriate carrier and coating materials. The use of non-volatile solvent causes improved wettability and ensures molecular dispersion of drug in the formulation and leads to enhance solubility.
D Kapoor +4 more
openaire +3 more sources
Development and characterization of solid dispersion for dissolution improvement of furosemide by cogrinding method. [PDF]
Adv Pharm Bull, 2014 Siahi-Shadbad MR +7 more
europepmc +2 more sources
Pharmaceutics, 2022 Two active pharmaceutical ingredients (APIs) with limited solubility, simvastatin and ezetimibe, prepared as a drug-drug solid dispersion (SD) was evaluated for physicochemical, microstructural, and aqueous dissolution properties.
Agata Górniak +4 more
doaj +1 more source
Pharmaceutics, 2023 The combination of statins and fibrates in the treatment of lipid abnormalities effectively regulates individual lipid fraction levels. In this study, the screening and assessment of the physicochemical properties of simvastatin-fenofibrate solid ...
Agata Górniak +4 more
doaj +1 more source
Design and Optimization of Lornoxicam Dispersible Tablets Using Quality by Design (QbD) Approach
Pharmaceuticals, 2022 The present study aims to design and optimize the lornoxicam dispersible tablet (LXDT) formulation using the Quality by design (QbD) approach. A randomized Box–Behnken experimental design was used to characterize the effect of the critical factors, such ...
Nawaf Almotairi +3 more
doaj +1 more source