Results 31 to 40 of about 5,089,703 (351)

Improvement of Dissolution Test Using Microdialysis Method

YAKUGAKU ZASSHI, 2009
Dissolution testing is a core performance test in pharmaceutical development and quality control. Generally, the HPLC method uses the analysis of dissolution testing. In this study, we attempted to improve the dissolution test by using microdialysis methods. We also investigated the comparison of the conventional HPLC dissolution method (batch-sampling
Noriaki, Nagai, Takatoshi, Murao, Yoshimasa, Ito   +2 more
openaire   +3 more sources

The Effect of Tween 20, 60, and 80 on Dissolution Behavior of Sprionolactone in Solid Dispersions Prepared by PEG 6000 [PDF]

Advanced Pharmaceutical Bulletin, 2015
Purpose: Solid dispersions have been efficient in improving the dissolution rate and bioavailability of hydrophobic drugs. The aim of the present study was enhancement of the dissolution profile of Spironolactone using solid dispersion.
Jafar Akbari, Majd Saeedi, Katayoun Morteza-Semnani, Hamid Reza Kelidari, Farshad Sadegh Moghanlou, Gity Zareh, Sohrab Rostamkolaei   +6 more
doaj   +1 more source

The dissolution and solid-state behaviours of coground ibuprofen–glucosamine HCl [PDF]

, 2014
The cogrinding technique is one of most effective methods for improving the dissolution of poorly water-soluble drugs and it is superior to other approaches from an economical as well as an environmental standpoint, as the technique does not require any ...
Ali Nokhodchi, Barzegar-Jalali M, Clegg DO, Ford JL, Hiba Al-Hamidi, Horton D, Kofi Asare-Addo, Mike Kitson, Sandip Desai   +8 more
core   +1 more source

Development of In Vitro Evaluation System for Assessing Drug Dissolution Considering Physiological Environment in Nasal Cavity

Pharmaceutics, 2022
Estimating the dissolution behavior of a solid in the nasal mucus is challenging for solid dosage forms designed for the nasal application as the solid dissolves into nasal mucus and permeates through the mucosa.
Daisuke Inoue, Ayari Yamashita, Hideto To   +2 more
doaj   +1 more source

Influence of excipients on spray-dried powders for inhalation [PDF]

, 2014
Two areas attracting considerable attention when developing effective pulmonary drug delivery systems include the improvement of aerosolisation efficiency of the inhaled formulation and the controlled release of drug from the formulation following ...
Adi, Azarmi, Begat, Chan, Chew, Chew, Conti, Corrigan, Coucke, Derom, Edwards, Ely, En-Yu Xu, Farid, Glover, Gray, Griesenbach, Hao-Ying Li, Hooton, Jalalipour, Jing Guo, Kamiya, Kobayashi, Learoyd, Learoyd, Li, Li, Li, Li, Li, Mishra, Momeni, Parsons, Patton, Peter C. Seville, Prakash Rao, Seville, Seville, Sham, Sinn, Sou, Sou, Ståhl, Vergote, Ying Xu, Zeng   +45 more
core   +1 more source

The role of phospholipid as a solubility- and permeability-enhancing excipient for the improved delivery of the bioactive phytoconstituents of Bacopa monnieri [PDF]

, 2016
In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed.
Bobde, Yamini S, Dave, Vivek S., Dhore, Pradip W., Gupta, Deepak, Mack, Connor, Raut, Nishikant, Saoji, Suprit   +6 more
core   +2 more sources

Alternative oral exemestane formulation: Improved dissolution and permeation

International Journal of Pharmaceutics, 2010
Exemestane (EXE) is an irreversible aromatase inactivator used for the treatment of advanced postmenopausal breast cancer. EXE is orally active but its bioavailability is about 5% due to its low solubility in water and the extensive first pass effect. It is known that cyclodextrin (CD) complexation enhances solubility and oral bioavailability of poorly
Yavuz, Burcin, Bilensoy, Erem, Vural, Imran, Sumnu, Murat   +3 more
openaire   +3 more sources

Role of Solvents in Improvement of Dissolution Rate of Drugs: Crystal Habit and Crystal Agglomeration [PDF]

Advanced Pharmaceutical Bulletin, 2015
Crystallization is often used for manufacturing drug substances. Advances of crystallization have achieved control over drug identity and purity, but control over the physical form remains poor.
Maryam Maghsoodi
doaj   +1 more source

Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach [PDF]

Pharmaceutics, 2020
In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically characterized and the solubility, dissolution rate, and
Xavier Buol, Koen Robeyns, Camila Caro Garrido, Nikolay Tumanov, Laurent Collard, Johan Wouters, Tom Leyssens   +6 more
openaire   +7 more sources

Improvement of the Solubility and Dissolution Characteristics of Risperidone via Nanosuspension Formulations

Iraqi Journal of Pharmaceutical Sciences, 2022
Risperidone is an atypical antipsychotic drug that is used for treating schizophrenia, bipolar mania, and autism. Risperidone rebalances dopamine and serotonin to improve thinking, mood, and behavior by working on dopamine and serotonin α2receptor ...
Hayder Emad, Shaimaa Nazar Abd-Alhammid
doaj   +1 more source